| Coverwise Holdings Limited | Information & communication | 2014 |
| Coxham Trading Ltd | Professional & scientific | 2026 |
| CPM Partners Limited | Information & communication | 2016 |
| Crecolo Limited | Information & communication | 2023 |
| Crilly Airways Limited | Extraterritorial | 2009 |
| Crispa Limited | Real estate | 2023 |
| Crown Gate Awards Ltd | Education | 2025 |
| Crucial Edge Limited | Professional & scientific | 2012 |
| CT Wellness Ltd | Wholesale & retail | 2026 |
| Ctparsons Ltd | Professional & scientific | 2023 |
| Cubat Limited | Administrative & support | 2000 |
| Curtainup Limited | Information & communication | 2025 |
| Curtis Electrical Limited | Construction | 2022 |
| Cyan Wolf Films Ltd | Information & communication | 2023 |
| D a Strachan Consulting Ltd | Professional & scientific | 2020 |
| D. Thackrah Social Care Consultancy Limited | Health & social care | 2015 |
| DAN Burn-Forti Ltd | Professional & scientific | 2010 |
| Dancy Building Contractors Limited | Construction | 2024 |
| Dansk Technik Limited | Administrative & support | 1996 |
| Daromo Ltd | Information & communication | 2023 |
| Darryl Newton Consulting Limited | Professional & scientific | 2018 |
| David Archibald Consulting Limited | Administrative & support | 2004 |
| David Boyle Projects Limited | Professional & scientific | 2009 |
| David Linley & Co Limited | Manufacturing | 1985 |
| David Linley Furniture Limited | Professional & scientific | 1998 |
| David Linley Holdings Limited | Professional & scientific | 1987 |
| David Snowdon Design Limited | Professional & scientific | 2017 |
| David Waters Design Limited | Professional & scientific | 2014 |
| DB Agri Limited | Agriculture & fishing | 2013 |
| Defenddigitalme Group | Other services | 2019 |
| Defib Tracker Limited | Other services | 2022 |
| Dentz Limited | Wholesale & retail | 2003 |
| Denyer Admin Limited | Professional & scientific | 2009 |
| Design'D Spaces Limited | Construction | 2018 |
| Digital Accountancy & Taxation Limited | Professional & scientific | 2017 |
| Discount Tyre Direct Limited | Wholesale & retail | 2006 |
| DMH (Sussex) Limited | Transport & logistics | 2003 |
| Dolphin Print Limited | Manufacturing | 2000 |
| Dore & Rees Motor Limited | Wholesale & retail | 2023 |
| Double the Cube Limited | Manufacturing | 2017 |
| Down to Earth Electrical Sussex Limited | Construction | 2026 |
| Downlands Holdings Limited | Professional & scientific | 2006 |
| Downlands Limited | Construction | 1994 |
| DR Louise Hallam Clinics Limited | Health & social care | 2021 |
| Drpj Limited | Real estate | 2024 |
| DTR Newnham Plastics Limited | Manufacturing | 2007 |
| Dundas Communications Limited | Administrative & support | 2011 |
| E.G.W Groundworks Ltd | Construction | 2024 |
| EAT Well for Life Ltd | Health & social care | 2023 |
| Echo Medical Communications Limited | Professional & scientific | 2018 |
| Eco-Centric Ltd | Professional & scientific | 2024 |
| Eightfold Marketing Ltd | Professional & scientific | 2023 |
| Elevate-Evolve Ltd | Health & social care | 2025 |
| Elite Hair and Beauty Training Academy Ltd | Other services | 2026 |
| Ella Sophia Design Ltd | Professional & scientific | 2023 |
| Elliot Andrews Creative Limited | Information & communication | 2022 |
| Emmacane Limited | Wholesale & retail | 1983 |
| Empathy UK Limited | Health & social care | 2005 |
| EN Spanish UK CIC | Professional & scientific | 2023 |
| Energy Jobline Limited | Administrative & support | 2011 |
| Energy Solutions & Design Limited | Energy | 2014 |
| Enersec Ltd | Information & communication | 2016 |
| Epicurus' Garden Ltd | Hospitality | 2023 |
| EQS Holdings Limited | Financial services | 2023 |
| EQS One Limited | Financial services | 2024 |
| Ergon Resources Limited | Administrative & support | 2011 |
| EU Screens Ltd | Information & communication | 2014 |
| Eurasain Solutions Ltd | Wholesale & retail | 2026 |
| Evileye Security Ltd | Information & communication | 2021 |
| Evolve Advisory Ltd | Professional & scientific | 2019 |
| Fade to Black Social Limited | Hospitality | 2015 |
| Faye Peach Designs Ltd | Professional & scientific | 2012 |
| Feba Radio. | Other services | 1968 |
| Fenghuang Exports Limited | Wholesale & retail | 2015 |
| Ferguson Walsh Ltd | Information & communication | 2000 |
| Feros Advisers Limited | Administrative & support | 2013 |
| Fetlock & Co Ltd | Transport & logistics | 2020 |
| Ffynnon Beuno Limited | Manufacturing | 2014 |
| Fiesta Mart Limited | Wholesale & retail | 2024 |
| Finansgruppen (UK) Management Limited | Administrative & support | 2006 |
| Finch Architecture Limited | Professional & scientific | 2006 |
| Findon Park Farm Limited | Agriculture & fishing | 1955 |
| Fingerfeet Productions Ltd | Information & communication | 2016 |
| First Brimstone Ltd | Professional & scientific | 2018 |
| Fitness Limited | Arts & recreation | 2019 |
| Five Fifty Alpha Limited | Real estate | 2026 |
| Five Fifty Capital Limited | Financial services | 2026 |
| Fizz Store Ltd | Wholesale & retail | 2020 |
| Fizzy Tea Ltd | Information & communication | 2020 |
| Flexible Finance People Ltd | Professional & scientific | 2012 |
| Flicker Rose Limited | Wholesale & retail | 2021 |
| Food 4 Ltd | Agriculture & fishing | 2023 |
| Four Grand Avenue (Hove) Freehold Limited | Real estate | 2012 |
| Four Grand Avenue (Hove) Management Limited | Households | 1977 |
| Four Physio Ltd | Other services | 2025 |
| Fowler Bros. Limited | Real estate | 1926 |
| Frankie Rossi Art Projects Limited | Wholesale & retail | 2023 |
| Freedom Finders Ltd | Wholesale & retail | 2026 |
| Freefort Ltd | Professional & scientific | 2013 |
| Furze Hill House (Hove) Limited | Households | 1982 |