| Shellwood Homes Ltd | Real estate | 2022 |
| Shelwell UK Limited | Real estate | 2023 |
| Sheridan Construction Management Limited | Construction | 2017 |
| Sherwood Place Management Company Limited | Households | 1984 |
| Shibella Care Ltd | Health & social care | 2023 |
| Shield CP UK Ltd | Administrative & support | 2023 |
| Shifa Consultancy Services Limited | Health & social care | 2022 |
| Shilbury Ltd | Real estate | 2024 |
| Shiloh House of Prayer Limited | Other services | 2022 |
| Shining Dawn Limited | Real estate | 2018 |
| Shining Dawn Properties Limited | Real estate | 2022 |
| Shiraz Property Management Ltd | Real estate | 2022 |
| Shire Court Management Company Limited | Households | 1997 |
| Shire Hill Garage Limited | Wholesale & retail | 2014 |
| Shire Property Installations Limited | Construction | 2006 |
| Shirewood Properties Limited | Real estate | 2022 |
| Shiva Solutions Limited | Information & communication | 2013 |
| Shook Creative Services Limited | Information & communication | 2013 |
| Shooter Limited | Extraterritorial | 2009 |
| Shopable Ltd | Wholesale & retail | 2021 |
| Shoplingo Ltd | Wholesale & retail | 2024 |
| Shopnet Limited | Wholesale & retail | 1997 |
| Shoppr Technologies Limited | Information & communication | 2021 |
| Shor-Tee Media Group Limited | Information & communication | 2022 |
| Short-Term Emergency Placements (Step) Ltd | Health & social care | 2019 |
| Shortmead Events Limited | Hospitality | 2023 |
| Shorty's (OFF Licence) Limited | Wholesale & retail | 2010 |
| Shotly Ltd | Information & communication | 2026 |
| Showcase Productions Limited | Information & communication | 1999 |
| Showstoppers Performing Arts Limited | Arts & recreation | 2024 |
| SHR Properties Limited | Real estate | 2020 |
| Shreeji Property Group Ltd | Real estate | 2022 |
| Shri Ganeshay Ltd | Wholesale & retail | 2023 |
| Shri Krishna Property Rental Services Ltd | Real estate | 2019 |
| Shurmaine Mccabe Limited | Health & social care | 2020 |
| Shéa Bradley Films Limited | Information & communication | 2020 |
| Shérendis Ltd | Wholesale & retail | 2025 |
| Sias Corp Limited | Wholesale & retail | 2015 |
| SICK2DEATH Apparel Limited | Manufacturing | 2026 |
| Sidibeh's Health Hub Ltd | Health & social care | 2023 |
| Siemon Martins Limited | Professional & scientific | 2016 |
| Sigma Foot Surgery Limited | Health & social care | 2025 |
| Sigma Forestry Limited | Administrative & support | 2024 |
| SIGMA369 Ltd | Administrative & support | 2026 |
| Sign-On Design Co. Limited | Construction | 2025 |
| Signals Therapeutics Ltd | Professional & scientific | 2026 |
| Signalstream Solutions Ltd | Administrative & support | 2024 |
| Signature Auto Repairs Ltd | Manufacturing | 2017 |
| Signature Estate Gardens Limited | Administrative & support | 2025 |
| Sikaba Healthcare Limited | Health & social care | 2021 |
| Silek Electrical Services Ltd | Construction | 2021 |
| Silenceofmusic.Com Limited | Administrative & support | 2009 |
| Silent Light Solutions Limited | Construction | 2018 |
| Silenus Films Ltd | Information & communication | 2025 |
| Silver Maple Healthcare Limited | Health & social care | 2018 |
| Silver Orca Ltd | Information & communication | 2025 |
| Silver PIG Film and Television Ltd | Information & communication | 2023 |
| Silverferne Ltd | Professional & scientific | 2018 |
| Silverfox Rigging Ltd | Construction | 2021 |
| Silvers Holdings Ltd | Real estate | 2021 |
| SIM Love Ltd | Information & communication | 2025 |
| Simcere UK Limited | Administrative & support | 2017 |
| Simon Brooks Films Ltd | Information & communication | 2021 |
| Simon Wright Photography Limited | Professional & scientific | 2008 |
| Simonkilnmusic Ltd | Information & communication | 2017 |
| Simplai-Fy Ltd | Information & communication | 2023 |
| Simple Gates and Security Ltd | Construction | 2019 |
| Simpletenders Ltd | Information & communication | 2019 |
| Simply Carpets & Flooring Camberley Limited | Wholesale & retail | 2017 |
| Simply Processing Ltd | Wholesale & retail | 2021 |
| Simpson & Co Barbers Ltd | Other services | 2024 |
| Simpson-Stewart Estate Agents Ltd | Real estate | 2023 |
| Sinclair Synergy Limited | Construction | 2012 |
| Singh & Sons Estates Ltd | Real estate | 2015 |
| Sink Included Limited | Construction | 2022 |
| Sips Carpentry Ltd | Construction | 2021 |
| Sirius Voyages Limited | Real estate | 2024 |
| Situation UK Limited | Professional & scientific | 2020 |
| SIV Developments Ltd | Professional & scientific | 2025 |
| Sivaen Group Ltd | Wholesale & retail | 2025 |
| SIX Hills Brewing Licencing Ltd | Administrative & support | 2022 |
| SIX Hills Crossfit Ltd | Arts & recreation | 2015 |
| Six-Five Productions Limited | Administrative & support | 2007 |
| Sixpence 21 Limited | Wholesale & retail | 2014 |
| Sixtysix Group (SSG) Ltd | Wholesale & retail | 2024 |
| Siyashi Ltd | Wholesale & retail | 2023 |
| Size Tailoring Ltd | Other services | 2021 |
| SJ Large Services Limited | Construction | 2014 |
| SJ3D Solutions Limited | Manufacturing | 2026 |
| Sjcooling Ltd | Construction | 2023 |
| SJD Product Sourcing & Distribution Ltd | Other services | 2022 |
| SJL Management Ltd | Professional & scientific | 2022 |
| SJM Building Limited | Construction | 2024 |
| SJM Network Solutions Limited | Information & communication | 2021 |
| Sjose Technologies Limited | Information & communication | 2026 |
| SJP Limited | Public administration | 2022 |
| Sjqr Consulting Limited | Professional & scientific | 2025 |
| SK & TR Building Services Ltd | Construction | 2013 |
| SK (WGL) Limited | Health & social care | 2011 |
| SK Health Consultancy Ltd | Public administration | 2023 |