| DJB Metropolitan Limited | Real estate | 2020 |
| DJH & Sons Limited | Construction | 2025 |
| DJH Building Ltd | Construction | 2022 |
| DJH Properties NE Ltd | Real estate | 2024 |
| DJM Electricals NE Ltd | Construction | 2026 |
| Dlpb Limited | Construction | 2025 |
| Dolphin Logistics Supply Chain Management UK Limited | Transport & logistics | 2023 |
| Donyal Engineering Limited | Manufacturing | 2005 |
| Donyal Group Limited | Financial services | 2015 |
| Donyal Holdings Limited | Professional & scientific | 1971 |
| Donyal Investments Limited | Financial services | 2015 |
| Doodle Education Ltd | Manufacturing | 2015 |
| Double a Glazing Ltd | Construction | 2004 |
| Dough and Desserts Ltd | Hospitality | 2025 |
| DP Groundworks, Plant & Commercial Ltd | Construction | 2020 |
| DPC Estates Limited | Professional & scientific | 2012 |
| DPC Sports Management Ltd | Arts & recreation | 2025 |
| DR Sean Education Limited | Education | 2021 |
| Dream Flyer Limited | Real estate | 2025 |
| Drive Safely Consultancy Limited | Education | 2024 |
| Driver Skills North East Ltd. | Education | 2018 |
| Drss Surfacing Ltd | Construction | 2021 |
| DTH Building Solutions Ltd | Administrative & support | 2023 |
| Duckland Living Limited | Real estate | 2020 |
| Dunelm Education LLP | | 2017 |
| Durham & Manchester Holdings Ltd | Financial services | 2021 |
| Durham Lets Ltd | Real estate | 2023 |
| Durham QA Ltd | Professional & scientific | 2023 |
| Dzamwari Consultancy Ltd | Professional & scientific | 2020 |
| E & C (UK) Co. Ltd | Real estate | 2020 |
| E & D Estates Ltd | Real estate | 2020 |
| E & E House Limited | Real estate | 2020 |
| E & K Pallets Woodchip Recycling Services Ltd | Manufacturing | 2013 |
| E & K Property Services Limited | Real estate | 2024 |
| E&A Engineering Ltd | Professional & scientific | 2025 |
| Ecbn UK Property Limited | Real estate | 2020 |
| Eden Hill Developments Ltd | Professional & scientific | 2015 |
| Edenleigh Group Ltd | Financial services | 2026 |
| Edge of Nowhere Ltd | Arts & recreation | 2018 |
| Edmorah Healthcare Limited | Health & social care | 2022 |
| EKA Home Limited | Real estate | 2023 |
| Elcoat and Eager Limited | Wholesale & retail | 2002 |
| Elegant Housing Limited | Real estate | 2023 |
| Eleven Eden Limited | Professional & scientific | 2005 |
| Eliot Smith Dance | Arts & recreation | 2015 |
| Elite Master Limited | Real estate | 2020 |
| ELM Court Equestrian Ltd | Agriculture & fishing | 2026 |
| ELM Court Farm Limited | Agriculture & fishing | 2015 |
| Embodé Skin Clinic Ltd | Other services | 2026 |
| Embra Again Productions Ltd | Arts & recreation | 2020 |
| Embrace Light Limited | Real estate | 2024 |
| Embrace Services Ltd | Information & communication | 2023 |
| Empire Print and Design Limited | Manufacturing | 2016 |
| Enchanted Occasions Ltd | Administrative & support | 2023 |
| Endless Joy Ltd | Manufacturing | 2019 |
| Enduracoat Solutions Ltd | Administrative & support | 2025 |
| Entirely Business (UK) Limited | Information & communication | 2010 |
| Entirely Business Limited | Information & communication | 2010 |
| Envelope Inspections & Remedials Ltd | Construction | 2024 |
| Epic Medical Limited | Health & social care | 2014 |
| Equiscense Horsemanship Ltd | Agriculture & fishing | 2024 |
| Equivista Ltd | Real estate | 2024 |
| Ernest Chadwick Limited | Real estate | 2020 |
| Essemus Militibus Ltd | Administrative & support | 2025 |
| Essential Trade Supplies Ltd | Wholesale & retail | 2025 |
| Etheridge Estates Ltd | Real estate | 2017 |
| Etheridge Holdings (NE) Ltd | Financial services | 2026 |
| Etheridge Windows Ltd | Construction | 2019 |
| Eukay Integrated Services Ltd | Wholesale & retail | 2025 |
| EW Tree Services Ltd | Agriculture & fishing | 2021 |
| Exclusively Limited | Real estate | 2019 |
| F. W. Amison Limited | | 1965 |
| Face by Amethyst Aesthetics Limited | Other services | 2023 |
| Fate Bound Publishing Limited | Information & communication | 2024 |
| FCM Properties and Investments Limited | Real estate | 2026 |
| FH Rapid Access Ltd | Construction | 2023 |
| Fine West Ltd | Real estate | 2020 |
| Fingertip Technologies UK Limited | Other services | 2015 |
| Fission Consulting Limited | Professional & scientific | 2014 |
| Fission Recruitment Limited | Administrative & support | 2026 |
| Flattline Fire Door Compliance Ltd | Construction | 2025 |
| Fling Media Limited | Information & communication | 2024 |
| Florida Syrups Ltd | Manufacturing | 2023 |
| FMD Motors Ltd | Wholesale & retail | 2024 |
| Fondley Sett Mews Limited | Agriculture & fishing | 2022 |
| Forever Friends Company Limited | Real estate | 2020 |
| Forever Jack Limited | Wholesale & retail | 2013 |
| Formosat Limited | Real estate | 2024 |
| Forric Developments (White-Le-Head) Ltd | Construction | 2020 |
| Founded Design Limited | Arts & recreation | 2010 |
| FOX Independent Financial Services Ltd | Financial services | 2005 |
| FOX Management (Swansea) Limited | Professional & scientific | 1999 |
| Framewood Properties Limited | Real estate | 2020 |
| Framing Unlimited (NE) Ltd | Other services | 2024 |
| Frank Ellison Limited | Manufacturing | 2022 |
| Friday Nice Ltd | Real estate | 2020 |
| Friday Solved Limited | Information & communication | 2024 |
| FRZ13 Ltd | Construction | 2026 |
| FSW Properties Ltd | Real estate | 2016 |
| FSW Retail Limited | Real estate | 1979 |