| RLR North East Ltd | Wholesale & retail | 2025 |
| RMT Access Limited | Professional & scientific | 2008 |
| Robby's Auto Dismantlers Limited | Water & waste | 2005 |
| Rockworks Limited | Construction | 2002 |
| Room 1109 Limited | Real estate | 2020 |
| Rooster Motorcycles & Salvage Limited | Wholesale & retail | 2007 |
| Roscoe Holdings Limited | Financial services | 2021 |
| Rosetta Consultancy Ltd | Professional & scientific | 2021 |
| Roundhay Business Limited | Construction | 2025 |
| RQA Consultants Limited | Information & communication | 2015 |
| RSM Group Holdings Limited | Financial services | 2025 |
| RSM Synergy Gym Limited | Arts & recreation | 2025 |
| RT & KL Limited | Real estate | 2024 |
| Rudder Ltd | Information & communication | 2025 |
| Ruffles & Barnes Media Ltd | Professional & scientific | 2010 |
| Ruffwear Europe Holdings Ltd | Wholesale & retail | 2015 |
| Ruffwear Europe Limited | Financial services | 2024 |
| Rumc Limited | Wholesale & retail | 2007 |
| Rynm UK Ltd | Construction | 2025 |
| S Burleigh Consulting Ltd | Construction | 2016 |
| S G I Consultancy Ltd | Professional & scientific | 2012 |
| S K Plastics Limited | Manufacturing | 1999 |
| S Steele Solutions Ltd | Information & communication | 2016 |
| S&J Roofing &Building Services Ltd | Construction | 2026 |
| S&N Fenwick 11.11 Limited | Professional & scientific | 2025 |
| S-I-R Formwork Solutions Ltd | Construction | 2025 |
| S.A.G North East Limited | Professional & scientific | 2018 |
| S.I.J Wilson, Lettings Ltd | Real estate | 2025 |
| S.Mac Motors Ltd | Wholesale & retail | 2022 |
| Safe Pasture Company Limited | Real estate | 2023 |
| Safety Checked Ltd | Administrative & support | 2017 |
| Saints Huberts Group Limited | Agriculture & fishing | 2026 |
| Salad Days Limited | Manufacturing | 1998 |
| Salvation Healthcare Limited | Health & social care | 2019 |
| Sand Developments (North East) Ltd | Real estate | 2024 |
| Sanjika Well ED Limited | Health & social care | 2024 |
| Saoirse Services Ltd | Health & social care | 2023 |
| SAY YES to Life Limited | Real estate | 2020 |
| Sbrm NE Limited | Administrative & support | 2026 |
| Scoobybitz Northeast Ltd | Wholesale & retail | 2025 |
| Scotswood Showbar Ltd | Hospitality | 2025 |
| Scotts Contracting & Lifts Limited | Professional & scientific | 2025 |
| Sea Horizon Limited | Real estate | 2026 |
| Seal Enterprises Limited | Real estate | 2017 |
| Selective Investment Group Limited | Real estate | 2023 |
| Semvra Limited | Manufacturing | 2021 |
| Serviced Accommodation Cleans Ltd | Administrative & support | 2022 |
| Sette Logistics & Consulting Ltd | Professional & scientific | 2024 |
| Shamrock Smoothies Ltd | Wholesale & retail | 2019 |
| Shieldhaven Holdings Ltd | Financial services | 2025 |
| Shoreline Inspection Services Ltd | Other services | 2024 |
| Shotleyfield Farm Residents Limited | Other services | 2009 |
| SIG & Chan Limited | Real estate | 2020 |
| Silverleaf Properties Limited | Construction | 1991 |
| Simuka Homes Limited | Construction | 2025 |
| SJE Property Investors Ltd | Real estate | 2018 |
| Skip and Waste Limited | Water & waste | 2026 |
| Skrt Ltd | Construction | 2025 |
| Smart-In Mortgages Limited | Financial services | 2023 |
| Smartgas Heating Services Ltd | Construction | 2021 |
| Smartglass Limited | Manufacturing | 2007 |
| Smartt North East Ltd | Education | 2010 |
| Smith & Co Accountants Limited | Professional & scientific | 2011 |
| Snackorbite Limited | Manufacturing | 2025 |
| Sone Products Holdings Ltd | Manufacturing | 2013 |
| Sone Products Ltd | Manufacturing | 2010 |
| Soptri Multi-Concept Limited | Wholesale & retail | 2026 |
| Soteria Risk Ltd | Administrative & support | 2022 |
| South Causey Limited | Hospitality | 2004 |
| South Moor Tandoori Ltd | Hospitality | 2025 |
| Southern Counties Homes Limited | Construction | 2015 |
| Southmoor Golf Club | Arts & recreation | 2014 |
| Spaniel Hospitality Ltd | Hospitality | 2019 |
| Specialist Ventilation Services Limited | Professional & scientific | 1998 |
| Spector Information Security Limited | Information & communication | 2020 |
| Speedcore Concrete Cutting Specialist Ltd | Construction | 2025 |
| SPF Psychotherapy and Counselling Ltd | Professional & scientific | 2022 |
| SPI Property Limited | Real estate | 2023 |
| SPICE&TREATZ2 Limited | Wholesale & retail | 2025 |
| Spidercise Ltd | Arts & recreation | 2011 |
| Sportevo Ltd | Wholesale & retail | 2018 |
| SST Group Limited | Administrative & support | 2013 |
| ST Cuthbert Press Ltd | Information & communication | 2024 |
| ST Stores Ltd | Wholesale & retail | 2026 |
| ST TT Retail Limited | Wholesale & retail | 2025 |
| Stage Tech Services Ltd | Arts & recreation | 2023 |
| Staglyn Commercials Limited | Wholesale & retail | 2012 |
| Staley Construction Ltd | Construction | 2022 |
| Stanford Global Limited | Financial services | 2018 |
| Stanley Bars and Co Ltd | Hospitality | 2025 |
| Stanley Classic Ltd | Hospitality | 2022 |
| Stanley Events Ltd | Arts & recreation | 2011 |
| Stanley Indoor Bowls Centre Ltd | Arts & recreation | 2012 |
| Stanley Tasty Limited | Hospitality | 2025 |
| Stanley Towbar Services (STS) Limited | | 1986 |
| Stanley Tower Ltd | Wholesale & retail | 2023 |
| Stanley Travel (North East) Limited | Transport & logistics | 2011 |
| Stanley Travel Holdings Limited | Financial services | 2023 |
| Stansway AS Limited | Construction | 2025 |
| Starbuys North East Limited | Administrative & support | 2023 |