| Combi-Nation (NW) Ltd. | Administrative & support | 2006 |
| Concentric.Cx Ltd | Information & communication | 2016 |
| Concordis Systems Ltd | Information & communication | 2005 |
| Conflict Media Ltd. | Information & communication | 2018 |
| Connor J Page Ltd | Other services | 2014 |
| Conroy Services Limited | Construction | 2020 |
| Cooper Campers Ltd | Manufacturing | 2021 |
| Copper Octopus Building Services Ltd | Construction | 2023 |
| Copper Octopus Plumbing & Heating Ltd | Construction | 2023 |
| Correct Care Training Ltd | Information & communication | 2020 |
| Cosmic Queen Ltd | Manufacturing | 2020 |
| Cosmo Bingo Halls Manchester Limited | Administrative & support | 2022 |
| Costanzelli Coaching Ltd | Professional & scientific | 2019 |
| CP Global Ventures Ltd | Wholesale & retail | 2026 |
| CPD Rigging Limited | Information & communication | 2019 |
| CPK Bro’S Limited | Wholesale & retail | 2025 |
| CPW Holdings Ltd | Extraterritorial | 2018 |
| Creative Dimensions Solutions Limited | Information & communication | 2024 |
| Crest Engineering Company Limited | Professional & scientific | 1976 |
| Cribs and Properties Ltd | Real estate | 2023 |
| Crimson Developments Limited | Real estate | 2024 |
| Crompton & ORD Brickwork Ltd | Construction | 2019 |
| Crompton Burns Limited | Households | 2020 |
| Crossley Design and Fabrication Limited | Manufacturing | 2019 |
| CRS Bodywork Centre Ltd | Wholesale & retail | 2022 |
| CSP Property Investments Ltd | Real estate | 2024 |
| CTL Global Capital Limited | Financial services | 2023 |
| Cupranaut Limited | Water & waste | 2012 |
| D M Veterinary Consultancy Limited | Professional & scientific | 2016 |
| D P K Motors Ltd | Wholesale & retail | 2013 |
| D S B Financial Limited | Financial services | 2022 |
| D1 Pilates Ltd | Arts & recreation | 2025 |
| Daffodils Gondal Ltd | Wholesale & retail | 2025 |
| Daffy's Horticulture Ltd | Administrative & support | 2025 |
| DAISYS2ROSES Limited | Transport & logistics | 2000 |
| Dalestone Limited | Real estate | 2006 |
| Damron Properties Ltd | Construction | 2023 |
| Danny MCR Barber Ltd | Other services | 2025 |
| Danyal Logistics Ltd | Transport & logistics | 2023 |
| DAO Holistic Limited | Health & social care | 2021 |
| Dash Dog Walking Ltd | Other services | 2020 |
| Davco Pubs Limited | Hospitality | 2022 |
| Davenport House Clinic Limited | Health & social care | 2008 |
| David Osborne Transport Services Ltd | Transport & logistics | 2014 |
| DB Garden Nurseries Ltd | Wholesale & retail | 2013 |
| DB Trading Solutions Ltd | Wholesale & retail | 2024 |
| Dec-Approved Limited | Construction | 2001 |
| Dedicas Ltd | Administrative & support | 2004 |
| DEE MAC Childcare Limited | Education | 2012 |
| DEL Suits Limited | Wholesale & retail | 2026 |
| Deliverability Ltd | Health & social care | 2025 |
| Designbee Ltd | Wholesale & retail | 2018 |
| Detailed Interiors Ltd | Construction | 2023 |
| Dette's Limited | Wholesale & retail | 2012 |
| DGS Property Improvements Ltd | Construction | 2024 |
| DGU Ltd | Construction | 2021 |
| Dhander Spice Limited | Hospitality | 2024 |
| DHL Homes Limited | Real estate | 2020 |
| Diamond Clinical Services Ltd | Education | 2025 |
| Diamond Skin Training Ltd | Education | 2023 |
| Diema Limited | Other services | 2010 |
| Direct Business & Accounting Services Limited | Professional & scientific | 2015 |
| Direct Current Consulting (UK) Limited | Professional & scientific | 2015 |
| Direct Medicare International Ltd | Health & social care | 2018 |
| DJ Ainsworth Limited | Real estate | 2026 |
| DJR Garages Ltd | Wholesale & retail | 2011 |
| Dolcetti Limited | Hospitality | 2022 |
| Dominic Halpin Limited | Arts & recreation | 2022 |
| Doodlepots Ltd | Professional & scientific | 2024 |
| Doris Worldwide Ltd | Information & communication | 2024 |
| Downtown Dessertz Limited | Wholesale & retail | 2022 |
| Downtownz Ltd | Hospitality | 2026 |
| Dragon Contracting Ltd | Information & communication | 2022 |
| Dramare Limited | Health & social care | 2023 |
| Drayman Advisory Ltd | Professional & scientific | 2026 |
| Driven 2 Limited | Education | 2003 |
| Dsecuk Ltd | Information & communication | 2014 |
| DSP & Co. Consultancy Limited | Professional & scientific | 2014 |
| DTN Project Management Services Limited | Other services | 2012 |
| Dunn's RAW Food Ltd | Wholesale & retail | 2021 |
| DVO Landscapes Ltd | Administrative & support | 2025 |
| DWH Property Maintenance Ltd | Administrative & support | 2025 |
| Dwsl Ltd | Professional & scientific | 2019 |
| Dxdesign Limited | Information & communication | 2013 |
| Dylex-Uk Ltd | Wholesale & retail | 2015 |
| E Petch Holdings Limited | Financial services | 2021 |
| E Woon Ltd | Wholesale & retail | 2017 |
| E. S. P. (North West) Limited | | 1985 |
| E. V. Chains Ltd. | Professional & scientific | 2016 |
| EAM Accounting Ltd | Professional & scientific | 2017 |
| Early Learners Day Nurseries Limited | Real estate | 2022 |
| Easicut Limited | Manufacturing | 2001 |
| East Manchester Rugby Club Ltd | Arts & recreation | 2025 |
| EB Mckay Limited | Professional & scientific | 2017 |
| Eco Travel Limited | Transport & logistics | 2012 |
| Ecotherm Mechanical Services Limited | Construction | 2016 |
| Editex Ltd | Real estate | 2001 |
| EH Cleaning Services Ltd | Administrative & support | 2026 |
| Eightyfour CIC | Arts & recreation | 2023 |
| ELB Complete Ltd | Education | 2023 |