| Spelthorne Direct Services Limited | Water & waste | 2020 |
| Spha Limited | Wholesale & retail | 2022 |
| Sphinx Commercial Properties Limited | Real estate | 2022 |
| Spire Consulting Ltd | Professional & scientific | 2024 |
| SPJ Financial Consultants Limited | Professional & scientific | 2022 |
| SPJ Trading Ltd | Wholesale & retail | 2019 |
| Splendour Care Ltd | Administrative & support | 2021 |
| Sport Stars Consulting Ltd | Arts & recreation | 2018 |
| Spreedly UK Limited | Information & communication | 2020 |
| Sprinkles by Sheran Ltd | Manufacturing | 2020 |
| Sprint Courier 1981 Ltd | Transport & logistics | 2023 |
| SQ8 Limited | Administrative & support | 2025 |
| SR GAS & Electricity Ltdg Ltd | Manufacturing | 2016 |
| SRA Financial Management Ltd | Professional & scientific | 2014 |
| SRC Systems Limited | Manufacturing | 1995 |
| SRI Datta SAI Infotech Ltd. | Information & communication | 2014 |
| SRI Datta SAI Infra Limited | Real estate | 2022 |
| Ssach Enterprises Ltd | Wholesale & retail | 2022 |
| Sswans Limited | Hospitality | 2022 |
| ST Benedict's Healthcare Limited | Health & social care | 2014 |
| ST James Tenants Management Limited | Households | 2010 |
| ST Maintenance Limited | Construction | 2020 |
| ST Michael Plumbing & Heating Ltd | Construction | 2012 |
| ST Peter’S Nursery Ltd | Health & social care | 2023 |
| St.Antony Beverages Ltd | Wholesale & retail | 2021 |
| Stagewise Ltd | Information & communication | 2021 |
| Staines Cars Limited | Transport & logistics | 2010 |
| Staines Essentials Ltd | Wholesale & retail | 2025 |
| Staines Massive Group Ltd | Water & waste | 2019 |
| Staines Motors Ltd | Wholesale & retail | 2025 |
| Staines Preparatory School Trust | Education | 1987 |
| Staines Tops Pizza Ltd | Hospitality | 2025 |
| Staines-Upon-Thames BID Limited | Other services | 2017 |
| Staines-Upon-Thames Day CIC | Administrative & support | 2026 |
| Stanton Stone Holdings Limited | Professional & scientific | 2024 |
| Stanton Stone Partners Limited | Water & waste | 2014 |
| Stanton Stone Services Limited | Professional & scientific | 2024 |
| Stanwell Motor Repairs Ltd | Wholesale & retail | 2013 |
| Star Cars Surrey Ltd | Transport & logistics | 2023 |
| Starfish Psychology Services Limited | Education | 2013 |
| Stately Construction Ltd | Construction | 2015 |
| Stately Roof Care Limited | Construction | 2025 |
| Station Road (Hampton) Management Co. Limited | Households | 1982 |
| Status Funerals Ltd | Other services | 2024 |
| Stellantis Construction Ltd | Construction | 2024 |
| Sterling Capital Solution Ltd | Financial services | 2021 |
| Sterling Computers Corporation (UK) Ltd | Information & communication | 2022 |
| Steron & Partners Limited | Administrative & support | 2010 |
| Steron Consulting Ltd | Administrative & support | 2019 |
| Steven Turner & Associates Limited | Professional & scientific | 2016 |
| Stirling Ellis Ltd | Administrative & support | 2020 |
| Stitches and Glue Limited | Arts & recreation | 2016 |
| Stng Properties Ltd | Real estate | 2020 |
| Stone Solutions Specialists Ltd | Wholesale & retail | 2023 |
| Storycellas Scenery Ltd | Financial services | 2024 |
| Strategic Oakment Medical Limited | Health & social care | 2025 |
| Strategic Shipping Company Limited | Transport & logistics | 1984 |
| Strategy & Engagement Limited | Professional & scientific | 2024 |
| Stratosfly Ltd | Wholesale & retail | 2025 |
| Stretch ME Limited | Construction | 2018 |
| Stripes Bidco Limited | Financial services | 2019 |
| Stripes Holdco Limited | Financial services | 2019 |
| Stripes Midco Limited | Financial services | 2019 |
| Strivolt Limited | Administrative & support | 2020 |
| Struxon Ltd | Administrative & support | 2025 |
| Stuart Writes Copy Ltd | Professional & scientific | 2022 |
| Studio 997 Limited | Arts & recreation | 2011 |
| Style Avenue Ltd | Other services | 2023 |
| Suave Executive Travel Ltd | Wholesale & retail | 2022 |
| Success Consultants Limited | Professional & scientific | 2025 |
| Successful Software Solutions Ltd | Information & communication | 2013 |
| SUE Events Ltd | Wholesale & retail | 2021 |
| Sukhraj Limited | Wholesale & retail | 2026 |
| Sun Couriers 2007 Ltd | Transport & logistics | 2023 |
| Sun J Ltd | Hospitality | 2021 |
| Sun Trading and Investments Limited | Construction | 2016 |
| Sun Tropics Ltd | Other services | 2023 |
| Sunesis Commercial Limited | Professional & scientific | 2017 |
| Sunmead Limited | Hospitality | 2003 |
| Sunningum Property Management Ltd | Administrative & support | 2013 |
| Sunnymeads Motor Company Ltd | Wholesale & retail | 2016 |
| Sunshine HCM Consulting UK Ltd | Information & communication | 2025 |
| Sunshine of London Limited | Wholesale & retail | 2024 |
| Sunside Homes Limited | Real estate | 2021 |
| Sunstone Consulting Solutions Limited | Information & communication | 2014 |
| Super GARDEN24 Limited | Administrative & support | 2021 |
| Super Services Plus Ltd | Wholesale & retail | 2018 |
| Super YOU Star Limited | Hospitality | 2026 |
| Superb Cuisine UK Limited | Hospitality | 2018 |
| Supercourier Grup Ltd | Transport & logistics | 2020 |
| Superjatt Limited | Wholesale & retail | 2022 |
| Supper Sonics Logistics Limited | Transport & logistics | 2025 |
| Surchi Ltd | Other services | 2023 |
| Surface MT Ltd | Information & communication | 2014 |
| Surrey and London Emergency Plumber Ltd | Construction | 2025 |
| Surrey Building and Refurbishment Ltd | Construction | 2022 |
| Surrey Business Express Ltd | Wholesale & retail | 2025 |
| Surrey C C Ltd | Manufacturing | 2024 |
| Surrey Carpentry and Construction Ltd | Manufacturing | 2020 |
| Surrey Drives and Forecourts Limited | Construction | 2017 |