| Secret Attic Limited | Information & communication | 2005 |
| Secret Garden Limited | Wholesale & retail | 2004 |
| Securagate Limited | | 1984 |
| SEE and Sea Limited | Information & communication | 2012 |
| SEE and Sea Properties Ltd | Real estate | 2017 |
| Seisdon UK Ltd | Water & waste | 2006 |
| Select Stairs Limited | Manufacturing | 2002 |
| Senior Ventilation Ltd | Wholesale & retail | 2023 |
| Sensible Transport Solutions Limited | Wholesale & retail | 2001 |
| Series Three Owners Club Limited | Other services | 1994 |
| Seven Acres (Uttoxeter) Management Company Limited | Real estate | 2021 |
| Seventy Three Design Limited | Professional & scientific | 2006 |
| Severn Eight Freight Limited | Administrative & support | 2004 |
| Shabab Restaurant & Takeaway Ltd | Hospitality | 2012 |
| Shades of Tean Limited | Other services | 2003 |
| Sharrymac Ltd | Administrative & support | 2024 |
| Sheanixer Ltd | Administrative & support | 2021 |
| Shebdon Plant Hire Limited | Administrative & support | 2007 |
| Sheldon Central Electrical Services Ltd | Construction | 2002 |
| Shire News Ltd | Wholesale & retail | 2019 |
| Shirewise Limited | Professional & scientific | 2003 |
| Shobnall Building Contractors Limited | Construction | 2000 |
| Shobnall Stores Limited | Wholesale & retail | 2005 |
| Sienne Property Limited | Real estate | 2022 |
| Simon Stowe (Solicitors) Limited | Professional & scientific | 2004 |
| Sing and LI Limited | Hospitality | 2020 |
| SJ Sutton Plastering Limited | Construction | 2003 |
| Skyviewer Limited | Construction | 2021 |
| Smarty's Investments Limited | Other services | 2007 |
| Smash on Crewe Limited | Hospitality | 2024 |
| Smithy Garage(Leek) Ltd | Wholesale & retail | 2003 |
| Snape Engineering Limited | Extraterritorial | 1980 |
| Social Care Assessment Services Limited | Health & social care | 2005 |
| Solmicrotek Limited | Water & waste | 2012 |
| Solutionsource Ltd | Information & communication | 2006 |
| Sourcedoctor Limited | Wholesale & retail | 2004 |
| Southwestern Corporation Holdings Limited | Professional & scientific | 2001 |
| Spaciotempo UK Ltd | Extraterritorial | 1972 |
| Spectrum Alloys Holdings Ltd | Professional & scientific | 2001 |
| Spex Certiprep Ltd. | Wholesale & retail | 1995 |
| Spiers SC Ltd | Real estate | 2024 |
| Spline and Gear Tools Ltd | Administrative & support | 2003 |
| Spooner & Co (Builders) Limited | Construction | 2006 |
| Spring Autos Ltd. | Wholesale & retail | 1997 |
| Spyder Bats Limited | Wholesale & retail | 2006 |
| Squires Gate Management Company Limited | Other services | 1992 |
| Srafuand Ltd | Administrative & support | 2021 |
| ST George Construction (Cannock) Limited | Construction | 2007 |
| ST Joseph's School House Community Centre Limited | Hospitality | 2003 |
| ST Peter's Properties Limited | Arts & recreation | 1989 |
| Stafford Valeting Limited | Administrative & support | 2022 |
| Staffordshire Wills Limited | Professional & scientific | 2007 |
| Standon House Limited | Health & social care | 1999 |
| Stanton Bicycles Ltd | Wholesale & retail | 2022 |
| Star Garage (Burntwood) Limited | Wholesale & retail | 2002 |
| Star Property Group Ltd | Other services | 2019 |
| Star Property Sourcing Limited | Other services | 2020 |
| Steer's Textured Ceilings Limited | Construction | 1997 |
| Steve Emery Roofing Limited | Construction | 2000 |
| Steve Wicks Transport Limited | Transport & logistics | 2007 |
| Stevenson Jones Opticians Limited | Wholesale & retail | 2008 |
| Stoke on Trent Festival Limited | Arts & recreation | 1970 |
| Stoke Van Hire Ltd | Administrative & support | 2007 |
| Stoke-On-Trent and North Staffordshire Theatre Trust Limited | Arts & recreation | 1967 |
| Stoke-On-Trent Repertory Theatre Limited | Arts & recreation | 1976 |
| Stoke-On-Trent Timber Company Ltd. | Manufacturing | 2002 |
| Stone Driving Services Limited | Wholesale & retail | 2003 |
| Stone Physiotherapy Clinic Limited | Health & social care | 2007 |
| Straightforward Solutions Limited | Professional & scientific | 2002 |
| Strands of Bridgtown Limited | Other services | 2003 |
| Streamline Construction Limited | Construction | 1994 |
| Stuart Jackson Associates Limited | Professional & scientific | 2002 |
| Style Windows (Midlands) Limited | Construction | 2006 |
| SUB Zero Refrigeration Limited | Energy | 2002 |
| Sukh Gill Limited | Professional & scientific | 2006 |
| Sunfield Electrical Contractors Limited | Construction | 2007 |
| Sunny Hill Takeaway Limited | Hospitality | 2023 |
| Sunrise Homes (Derbyshire) Limited | Construction | 2007 |
| Super-Rod (Stoke-On-Trent) Ltd. | Administrative & support | 1998 |
| Superior Showhome Services Limited | Administrative & support | 2003 |
| Sutton Park Holdings Limited | Wholesale & retail | 2003 |
| Sutton Park Motor Company Limited | Wholesale & retail | 1965 |
| Sweeney Todds Barbers Shop Limited | Other services | 2005 |
| SWG Vibrodynamics Limited | Manufacturing | 2000 |
| Swinnerton Cycles Limited | Wholesale & retail | 2006 |
| Synesthesia Limited | Information & communication | 2024 |
| T & G Humphris (UK Holdings) Limited | Other services | 2022 |
| T & G Humphris Ltd | Construction | 2022 |
| T & L Investment Properties Limited | Real estate | 2006 |
| T Morris Contractors Limited | Other services | 2003 |
| T. G. Holdcroft (Newcastle) Limited | Wholesale & retail | 1988 |
| T. G. Hughes & SON Limited | Construction | 2000 |
| T.G. Holdcroft (Motors) Limited | Wholesale & retail | 1973 |
| TAB Commercial Holdings Ltd | Construction | 2026 |
| Tahir Aviation UK Ltd | Administrative & support | 2022 |
| Tammy Kaka Company Limited | Financial services | 2018 |
| Tamworth Chiropractic Clinic Ltd | Professional & scientific | 2004 |
| Tamworth Fabrication & Maintenance Limited | Construction | 2001 |
| Tamworth Toolbox Limited | Wholesale & retail | 2006 |
| Tanzotique Limited | Other services | 2003 |