| DPC Joinery Ltd | Other services | 2018 |
| DR LJR Limited | Health & social care | 2023 |
| Dragon Defence Industries Ltd | Wholesale & retail | 2026 |
| Drew Builders & Developers Limited | Construction | 2025 |
| Drop in Bangor Limited | Real estate | 2017 |
| Drpi Limited | Information & communication | 2008 |
| DTM Parry & Associates Ltd | Other services | 2015 |
| DUB Stance Ltd | Administrative & support | 2026 |
| Dwell Estate Agents Chester Limited | Real estate | 2014 |
| Dyachenko Mortgages Limited | Financial services | 2017 |
| Dyffryn Rentals Ltd | Real estate | 2023 |
| Dyserth Hall Mews Limited | Households | 1998 |
| E&P Property Developments Ltd | Construction | 2025 |
| E.W.Morris(Mostyn)Limited | Agriculture & fishing | 1953 |
| East West Exchange Limited | Wholesale & retail | 2024 |
| EAT Train Live Fitness Ltd | Arts & recreation | 2017 |
| Eccleston Management Limited | Professional & scientific | 2015 |
| Eco Built Homes Limited | Construction | 2020 |
| Educonnect Global Limited | Administrative & support | 2006 |
| Edwards Rental Property Limited | Real estate | 2007 |
| Efailrhos Garage CYF | Wholesale & retail | 2022 |
| Eirias Coastal Park Hotel Ltd | Hospitality | 2026 |
| Elexsys Ltd | Professional & scientific | 2019 |
| Elimbac Ltd | Manufacturing | 2012 |
| Elite Marketing and Communications International Ltd | Professional & scientific | 2012 |
| Elite Safety Professionals Ltd | Professional & scientific | 2020 |
| Elite Truck Repairs Limited | Wholesale & retail | 2017 |
| Ellicoe Consultancy Ltd | Professional & scientific | 2023 |
| Ellie Energy Limited | Financial services | 2022 |
| Ellis's Limited | Hospitality | 2013 |
| ELO Electrical and Renewables Limited | Administrative & support | 2021 |
| Elwy Holdings Limited | Manufacturing | 2017 |
| Em's Stores Ltd | Wholesale & retail | 2014 |
| Ember Automation Limited | Information & communication | 2025 |
| Emerald BI Limited | Other services | 2019 |
| Empowering Prosperity Ltd | Education | 2021 |
| Energy Potential Consulting Limited | Professional & scientific | 2020 |
| Energy Potential Tech Solutions Limited | Information & communication | 2020 |
| Engtech Electrical Contractors Ltd | Other services | 2018 |
| Ennio Chef Limited | Other services | 2019 |
| Envision Home and Gardens Ltd | Construction | 2025 |
| Equipment Tracking Limited | Administrative & support | 2004 |
| Equiti Engineering Limited | Manufacturing | 2026 |
| Esmor Laboratories Limited | Real estate | 1965 |
| ESW Civil Engineering CYF | Construction | 2026 |
| Euro Digital Systems (North Wales) Limited | Wholesale & retail | 2016 |
| Eurostep Limited | Information & communication | 1995 |
| Event Dancefloors Ltd | Administrative & support | 2017 |
| Event Lounge Ltd | Administrative & support | 2017 |
| Evison Holdings Limited | Financial services | 2025 |
| Excel Bathroom Solutions Ltd | Construction | 2025 |
| Excel Solutions Holdings Ltd | Financial services | 2025 |
| Excelheat Solutions Ltd | Construction | 2015 |
| Facilities Resource & Supplies Ltd | Wholesale & retail | 2025 |
| Fair FEE Estate Agents Limited | Extraterritorial | 2019 |
| Fair FEE Limited | Extraterritorial | 2019 |
| Fairfee Financial Limited | Financial services | 2019 |
| Farley Automotive Ltd | Wholesale & retail | 2026 |
| Fawkes Newco 1 Limited | Manufacturing | 2024 |
| FCR NW Ltd | Other services | 2020 |
| Fennton Construction Limited | Construction | 2019 |
| Fennton Developments Limited | Construction | 2019 |
| Fennton Group Limited | Construction | 2019 |
| Fennton Limited | Construction | 2019 |
| Ffynnon Flow Limited | Other services | 2024 |
| Fifth Dimension Industries Ltd | Wholesale & retail | 2025 |
| Fire Safety Wales (NW) Limited | Administrative & support | 2017 |
| First Steps Day Nursery (Rhos-On-Sea) Limited | Health & social care | 2012 |
| Fishguard Bay Limited | Hospitality | 2017 |
| Fishguard Bay Resort Limited | Hospitality | 2013 |
| Fishpool Delamere Limited | Hospitality | 2024 |
| Five Acres Property Limited | Real estate | 2022 |
| Flatfoot Enterprises Limited | Construction | 2003 |
| Fleetserve Valeting Limited | Wholesale & retail | 2018 |
| Flexace Products Ltd | Wholesale & retail | 2020 |
| Flucon Pumps Limited | Manufacturing | 1996 |
| FMR Stonemasonry Ltd | Construction | 2020 |
| Folium Labs Ltd | Wholesale & retail | 2026 |
| Fordent Holdings Limited | Real estate | 2002 |
| Fordent Investments Limited | Real estate | 2012 |
| Fordent Newco 1 Limited | Real estate | 2017 |
| Fossil Rock Ltd | Information & communication | 2019 |
| Fouche Bathrooms Ltd | Other services | 2016 |
| FOX Glove Property Management Limited | Households | 2019 |
| Foxglove and Daisy Limited | Wholesale & retail | 2020 |
| Fraser Designs (London) Limited | Professional & scientific | 2003 |
| Frost Family Enterprises Ltd | Other services | 2020 |
| FSW Psychology Ltd | Health & social care | 2023 |
| FT Services (NW) Ltd | Other services | 2018 |
| Further and Further Strategies UK Limited | Administrative & support | 2020 |
| Fusetec Limited | Construction | 2016 |
| G & G Foods Wholesale Ltd | Wholesale & retail | 2023 |
| G & J Commercials Limited | Real estate | 2025 |
| G & L Jones Ltd | Agriculture & fishing | 2015 |
| G E Roofing Ltd | Construction | 2026 |
| G-Evans and SON Ltd | Other services | 2019 |
| Gabriela Roscelli Ltd | Health & social care | 2020 |
| Galileo Data Consulting Limited | Information & communication | 2024 |
| Ganapathi Consultancy Ltd | Professional & scientific | 2010 |
| Garej Pennant CYF | Wholesale & retail | 2025 |