| Riverside Skips Limited | Water & waste | 2018 |
| RMD Automation and Control Ltd | Information & communication | 2019 |
| Road, Performance & Motorsport (RPM) Ltd | Wholesale & retail | 2018 |
| Roberts Food Group Ltd | Hospitality | 2022 |
| Rockstar Retirement Ltd | Professional & scientific | 2026 |
| Roko Hall Estates Ltd | Real estate | 2025 |
| Roloz Limited | Hospitality | 2021 |
| Rosen Homes Ltd | Real estate | 2019 |
| Ross Day Ltd | Hospitality | 2014 |
| Rovingcare Ltd | Health & social care | 2024 |
| Rowe & Bear Ltd | Information & communication | 2014 |
| RTJ Properties (NW) Ltd | Real estate | 2022 |
| Ryan 'the Butcher' MAC Ltd | Arts & recreation | 2024 |
| S a S Estates Limited | Real estate | 1997 |
| S J Offshore Services Ltd | Construction | 2015 |
| S J Wallis Roofing Contractors Limited | Construction | 2013 |
| S&K Property Group (NW) Ltd | Real estate | 2022 |
| S.A.W Carpentry & Joinery Ltd | Administrative & support | 2017 |
| S.J.W Graphics Ltd | Professional & scientific | 2025 |
| S.P.Health and Safety Services Limited | Professional & scientific | 2013 |
| S.Pailor Ltd | Administrative & support | 2017 |
| Safety and Power Solutions Ltd | Professional & scientific | 2019 |
| Safety Critical Training Limited | Education | 2022 |
| Salvatori Sparta Ltd | Wholesale & retail | 2026 |
| SAM Jones Property Ltd | Real estate | 2026 |
| SAM Roberts Ltd | Construction | 2023 |
| Sandown Painting Services Limited | Professional & scientific | 2014 |
| Sandringham Logistics Limited | Administrative & support | 2016 |
| SAP Asset Management Ltd. | Professional & scientific | 2019 |
| SBB Safety Ltd | Professional & scientific | 2021 |
| Scitec-Labs Ltd | Professional & scientific | 2015 |
| Sclt Developments Ltd | Construction | 2026 |
| Sea & Land Flavours of Portugal Ltd | Other services | 2019 |
| Seam Resourcing Limited | Administrative & support | 2025 |
| Sean Conway Academy CIC | Education | 2024 |
| Sean Conway Limited | Arts & recreation | 2014 |
| Sebright Garage Limited | Wholesale & retail | 2024 |
| Secure National Parking Group Limited | Extraterritorial | 2019 |
| Sellmorebetter Ltd | Professional & scientific | 2019 |
| Semed Group Ltd | Administrative & support | 2025 |
| Send Mediators Ltd | Professional & scientific | 2025 |
| Sensing Co Ltd | Wholesale & retail | 2022 |
| Seob Properties Ltd | Real estate | 2026 |
| Sethi Health Limited | Health & social care | 2024 |
| Sewell Enterprises Limited | Other services | 2018 |
| Sewell Industries Limited | Professional & scientific | 2010 |
| SGS Solutions Ltd | Other services | 2018 |
| Sharon Gray Limited | Education | 2015 |
| SHB Asset Management Ltd | Professional & scientific | 2016 |
| SHB Safety Ltd. | Construction | 2016 |
| Shoulder and Elbow Orthopaedic Unit Ltd | Professional & scientific | 2010 |
| Shreif Medical and Medicolegal Ltd | Health & social care | 2026 |
| Siabod Construction Limited | Construction | 2019 |
| Side Quest Vintage Limited | Wholesale & retail | 2026 |
| Silvestria Ltd | Administrative & support | 2023 |
| Simon Bates Builders Ltd | Real estate | 2020 |
| Simon Poole Limited | Financial services | 2015 |
| Simply Monty Ltd | Information & communication | 2025 |
| Sinchana Private Medical Services Limited | Health & social care | 2012 |
| Sional Ltd | Manufacturing | 2007 |
| Site Align Ltd | Administrative & support | 2017 |
| SJH Asset Management Ltd | Extraterritorial | 2018 |
| Skye Parker Racing Limited | Arts & recreation | 2026 |
| SLR Services NW Ltd | Health & social care | 2018 |
| Smart 3 Solutions Ltd | Professional & scientific | 2019 |
| Smashed and LIT Limited | Hospitality | 2024 |
| SNF Consulting Limited | Professional & scientific | 2015 |
| Snowdonia Land Limited | Real estate | 2019 |
| Soaltar Limited | Real estate | 2017 |
| Social Intent Limited | Professional & scientific | 2023 |
| Sola Designs Limited | Arts & recreation | 2019 |
| SOLAR247 Limited | Construction | 2022 |
| Soteria Global Ltd | Professional & scientific | 2023 |
| Soteria Safety Solutions Ltd. | Energy | 2023 |
| Soughton Shoot Limited | Arts & recreation | 2010 |
| Southern Care Group Limited | Health & social care | 2006 |
| Sovereign Funeral Services Limited | Other services | 2015 |
| Spargo-Thompson Ltd | Real estate | 2016 |
| Specialist Wildlife Services Limited | Professional & scientific | 2017 |
| Sportshog Ltd | Wholesale & retail | 2023 |
| Springbok Services (N.W) Ltd | Other services | 2020 |
| SS Services (Bath) Limited | Other services | 2014 |
| ST Asaph Community Hub CIC | Real estate | 2026 |
| Stabilitas Advisory Limited | Professional & scientific | 2023 |
| Star Units Limited | Health & social care | 2017 |
| Statron (UK) Limited | Manufacturing | 2003 |
| Steeltech N.W. Ltd | Professional & scientific | 2011 |
| Steer Alignments Wales Limited | Manufacturing | 2013 |
| Steiner Waldorf Schools Fellowship Limited | Education | 1953 |
| Stephanie Daniels Limited | Professional & scientific | 2016 |
| STO Bene Brothers Ltd | Hospitality | 2025 |
| Stratos Motorsport Services Ltd | Arts & recreation | 2024 |
| Street Dawg Ltd | Wholesale & retail | 2016 |
| Studholme Developments Limited | Real estate | 2021 |
| Studio 89 Tattoo & Body Piercing Limited | Other services | 2019 |
| Superloob Ltd | Wholesale & retail | 2023 |
| Supply Chain Projects UK Limited | Real estate | 2000 |
| Suzies Jewellery Ltd | Other services | 2017 |
| Swann Facilities Midlands Ltd | Construction | 2015 |
| Swayne Johnson Wealth Management Limited | Financial services | 2016 |