| South Holland Exterior Cleaning Limited | Administrative & support | 2025 |
| South Holland Holdings Ltd | Professional & scientific | 2024 |
| South Holland Local Housing Community Interest Company | Construction | 2008 |
| South Holland Moving Forwards CIC | Education | 2022 |
| South Holland Property Management Limited | Real estate | 2008 |
| South Holland Roofing Ltd | Construction | 2026 |
| South Holland Services Limited | Extraterritorial | 2007 |
| South Linc's Kitchens Ltd | Construction | 2023 |
| South Lincolnshire Investments Ltd | Real estate | 2015 |
| South Lincs Chilled Couriers Limited | Transport & logistics | 2009 |
| South Lincs Construction Limited | Construction | 1983 |
| South Lincs Consulting Limited | Professional & scientific | 2005 |
| South Lincs Contracting Ltd | Construction | 2020 |
| South Lincs Plant Hire and Sales Limited | Administrative & support | 1975 |
| South Lincs Plant Hire Holdings Limited | Financial services | 2020 |
| South Lincs Security Limited | Administrative & support | 2018 |
| South Lincs Services Limited | Administrative & support | 2022 |
| South Lincs Surveyors Ltd | Professional & scientific | 2021 |
| South Lincs Transport Ltd | Transport & logistics | 2021 |
| South Lincs Woodchip and Aggregates Ltd | Agriculture & fishing | 2022 |
| South Staff's Travel Limited | Transport & logistics | 2009 |
| Southeast Roofing & Building Ltd | Construction | 2025 |
| Southern Cladding Solutions Ltd | Construction | 2022 |
| Southern Counties Roof Care Ltd | Construction | 2025 |
| Southern Cross Agency Ltd | Administrative & support | 2008 |
| Southern Cross Personnel Ltd | Administrative & support | 2014 |
| Southern K9 Training & Services Limited | Administrative & support | 2023 |
| Southlincsdecor Ltd | Construction | 2026 |
| Sovereign Homes Holdings Ltd | Professional & scientific | 2008 |
| Sowaracing Ltd | Transport & logistics | 2015 |
| SP Brickwork Ltd | Construction | 2020 |
| SP Trans (NE) Ltd | Transport & logistics | 2022 |
| Space Shuttle Ltd | Transport & logistics | 2019 |
| Spak Ltd | Transport & logistics | 2017 |
| Spalding Auction Limited | Wholesale & retail | 1998 |
| Spalding Auto Electrical Limited | Wholesale & retail | 1983 |
| Spalding Badminton Club Ltd | Arts & recreation | 2024 |
| Spalding BID Ltd | Other services | 2024 |
| Spalding Brothers Ltd | Real estate | 2022 |
| Spalding Car Sales Limited | Wholesale & retail | 2014 |
| Spalding Car Wash Ltd | Wholesale & retail | 2024 |
| Spalding Carpets Ltd | Wholesale & retail | 2002 |
| Spalding Central Car Wash Ltd | Wholesale & retail | 2026 |
| Spalding Chilled Express Ltd | Transport & logistics | 2019 |
| Spalding Cleaning Services Ltd | Administrative & support | 2011 |
| Spalding Commercial Cleaning Services Limited | Other services | 2010 |
| Spalding Construction Ltd | Construction | 2020 |
| Spalding Container Storage Ltd | Extraterritorial | 2024 |
| Spalding Curry House Ltd | Hospitality | 2026 |
| Spalding Drain Services Ltd | Water & waste | 2026 |
| Spalding Driveways Ltd | Construction | 2025 |
| Spalding Farm Shop Limited | Wholesale & retail | 2005 |
| Spalding Firewood Limited | Manufacturing | 2026 |
| Spalding Flower Parade CIC | Administrative & support | 2024 |
| Spalding Food Store Ltd | Wholesale & retail | 2025 |
| Spalding Golf Club Limited | Arts & recreation | 2025 |
| Spalding Grammar School | Education | 2013 |
| Spalding Industrial Cleaning Services Ltd | Administrative & support | 2019 |
| Spalding Kebab Shop Ltd | Hospitality | 2019 |
| Spalding Masonic Hall Company Limited | Other services | 1965 |
| Spalding Medical Limited | Other services | 2002 |
| Spalding Nails Ltd | Other services | 2023 |
| Spalding Office Park Management Company Limited | Real estate | 2011 |
| Spalding Performance Academy Ltd | Arts & recreation | 2020 |
| Spalding Removals Ltd | Transport & logistics | 2026 |
| Spalding Restaurant Ltd | Hospitality | 2022 |
| Spalding Rugby Football Club Limited | Arts & recreation | 2010 |
| Spalding Spices Limited | Hospitality | 2023 |
| Spalding Storage Limited | Other services | 2020 |
| Spalding Store Ltd | Wholesale & retail | 2026 |
| Spalding Taxis Ltd | Transport & logistics | 2015 |
| Spalding Town Youth Football Club Ltd | Arts & recreation | 2024 |
| Spalding Transport Management Ltd | Administrative & support | 2021 |
| Sparta Developments Enterprise Limited | Construction | 2022 |
| Specialist on Site Services Limited | Administrative & support | 2010 |
| Specialist Sports Therapy Ltd | Health & social care | 2025 |
| Specialist Training and Consulting Company Ltd | Professional & scientific | 2021 |
| Specialized Distribution (Spalding) Limited | Transport & logistics | 2009 |
| Specky and Ginge Ltd | Professional & scientific | 2019 |
| Spedycja & Transport Exspres Trans Ltd | Transport & logistics | 2017 |
| Speedy Flight Club Ltd | Professional & scientific | 2023 |
| Sphere Cleaning Services Limited | Administrative & support | 2023 |
| Sphynxfashion Ltd | Wholesale & retail | 2024 |
| Spice Xpress Ltd | Hospitality | 2022 |
| Spin Pixel Ltd | Professional & scientific | 2018 |
| Spinney Rewinds Limited | Manufacturing | 2010 |
| SPK Roofing and Guttering Ltd | Construction | 2024 |
| Sports Pass Ltd | Wholesale & retail | 2014 |
| Sportsinjurylondonclinic Ltd | Health & social care | 2021 |
| SPR Drive Hire Ltd | Transport & logistics | 2017 |
| Spriggs & Co Limited | Professional & scientific | 2013 |
| Spriggs Probate Services Limited | Professional & scientific | 2024 |
| Springers Club Limited | Education | 2015 |
| Springfields (Enterprises) Limited | Other services | 1993 |
| Springfields Horticultural Society Limited(The) | Arts & recreation | 1966 |
| SR Lounge Ltd | Hospitality | 2025 |
| SRI Lanka Holidays Ltd | Administrative & support | 2020 |
| Srisha Viva Ltd | Real estate | 2025 |
| SRL (Spalding) Ltd | Wholesale & retail | 2020 |
| SRP Transport Ltd | Administrative & support | 2015 |