| Peace of Mind .925 Limited | Manufacturing | 2001 |
| Peach Software Ltd | Information & communication | 2010 |
| Pedge ROW Services Limited | Information & communication | 2011 |
| Pendulum Worthing Limited | Wholesale & retail | 2018 |
| Perolo Limited | Administrative & support | 2018 |
| Pet Essentials Limited | Transport & logistics | 2001 |
| Phillips and Still Limited | Real estate | 2013 |
| Piers Peel Studio Limited | Manufacturing | 2020 |
| Pilbeam Holdings Limited | Professional & scientific | 2008 |
| Pinewood Gate Residents Association Limited | Real estate | 1998 |
| Podia-Clinic Limited | Health & social care | 2006 |
| Portland Mansions Residents Association Limited | Households | 1994 |
| Prim and Proper Productions Ltd | Arts & recreation | 2014 |
| Priory Car Sales Limited | Wholesale & retail | 2009 |
| Professional Racing Connections Ltd. | Extraterritorial | 1999 |
| Project-Isle Limited | Wholesale & retail | 2019 |
| Protectawall Limited | Construction | 1996 |
| Pudding Ltd. | Information & communication | 2014 |
| Pullve T Ltd | Wholesale & retail | 2015 |
| R M D Consulting Ltd | Information & communication | 2007 |
| R Roofing Contractors Limited | Construction | 2017 |
| Rachel Holland Ltd | Arts & recreation | 2011 |
| RC Carpentry & Building Limited | Construction | 2020 |
| Realmac Properties Limited | Real estate | 2012 |
| RH Sculpture Limited | Arts & recreation | 2024 |
| Rhianna Dhillon Ltd | Information & communication | 2011 |
| Richmond Court (Hove) Limited | Households | 2008 |
| Riverside (Newhaven) Management Company Limited | Households | 2001 |
| RJW Bradshaw Ltd | Manufacturing | 2013 |
| Rosie FOX London Limited | Wholesale & retail | 2014 |
| Rosie FOX Ltd | Manufacturing | 2025 |
| Rotech Electrical Limited | Construction | 2013 |
| Rothman Racing Limited | Other services | 2014 |
| Royall Best Ltd | Real estate | 2023 |
| S.D. Holdings Limited | Construction | 1954 |
| SAN Jose Investments Limited | Real estate | 2014 |
| Sash Craft Limited | Construction | 1998 |
| Sava Jewellery Ltd | Wholesale & retail | 2023 |
| Saviour Goalkeeping Ltd | Wholesale & retail | 2017 |
| Scantlebury Holdings Limited | Administrative & support | 2015 |
| SCI Holdings Group Limited | Financial services | 2021 |
| SCI Projects Limited | Construction | 2021 |
| Seico Insurance & Mortgages Limited | Financial services | 1995 |
| Select Enterprises (Investments) Limited | Real estate | 1962 |
| Seneca Digital Ltd | Information & communication | 2018 |
| Shedfield Lodge Care Home Limited | Health & social care | 2021 |
| Shore Events Limited | Administrative & support | 2014 |
| Simply Human Ltd | Education | 2019 |
| Sjdm Limited | Information & communication | 2010 |
| Smartlet Property Reporting Ltd | Households | 2017 |
| Southwick Square Meats Limited | Wholesale & retail | 2008 |
| Space Generation Ltd | Professional & scientific | 2022 |
| Spanish Rental Properties Limited | Real estate | 2012 |
| Specnoll Limited | Construction | 1977 |
| Spectrum Plumbing Team Ltd. | Construction | 2020 |
| Sports Entertainment Marketing Ltd | Professional & scientific | 2012 |
| Stratton Court Management Limited | Households | 1995 |
| Stretch Yourself Limited | Arts & recreation | 2017 |
| Style Accountants Limited | Professional & scientific | 2008 |
| Summit Case Management Group Ltd | Health & social care | 2015 |
| Sussex Damp Surveyors Ltd | Professional & scientific | 2018 |
| Sussex Gardens and Estates Ltd | Administrative & support | 2012 |
| Sussex Marine Watersports Ltd | Transport & logistics | 2001 |
| Sussex Port Forwarding Limited | Transport & logistics | 1991 |
| Sussex Square Limited | Households | 1991 |
| Swedish Interior Design Ltd | Other services | 2011 |
| Sword Daniels Estates Limited | Real estate | 1947 |
| T L Hana Limited | Other services | 2022 |
| T. Laver Flooring Limited | Construction | 2026 |
| Taikai Properties Ltd | Real estate | 2011 |
| Taylor Carpentry and Building Services Ltd | Construction | 2018 |
| Techin' Care of Business Ltd | Professional & scientific | 2012 |
| THE Barbership Limited | Other services | 2015 |
| THE Brilliant Brighton Company Limited | Arts & recreation | 2011 |
| THE Celtic Bench Limited | Manufacturing | 2015 |
| THE Ecoedge Group Ltd | Wholesale & retail | 2023 |
| THE Haven Management Company (Denmead) Limited | Households | 2023 |
| THE Holiday Boutique Limited | Administrative & support | 2021 |
| THE Human Hive Global CIC | Education | 2017 |
| THE PEA POD of Arundel Ltd | Hospitality | 2021 |
| THE Wood Gallery Limited | Construction | 1997 |
| Theo Alexander Limited | Wholesale & retail | 2022 |
| TOM Clohosy Cole Ltd | Arts & recreation | 2019 |
| Towner Carpentry Ltd | Administrative & support | 2017 |
| Townley Wells Limited | Real estate | 1981 |
| Trafalgar View RTM Company Limited | Households | 2014 |
| Treepig Ltd | Administrative & support | 2021 |
| Trenlands Limited | Households | 1974 |
| TTP Partners Limited | Professional & scientific | 2018 |
| Tunsgate Residents Company Limited | Households | 1993 |
| TZ Property Holdings Limited | Construction | 2026 |
| V1 Tour Production Ltd | Information & communication | 2013 |
| Valtura Equity Holdings Ltd | Education | 2025 |
| VE the Agency Ltd | Information & communication | 2024 |
| Victoria Road (Brighton) Management Company Limited | Real estate | 2002 |
| Viper IT Group Limited | Information & communication | 2001 |
| Viper IT Solutions Ltd | Information & communication | 2009 |
| Voyage Marine Services Ltd | Transport & logistics | 2020 |
| Ward Environmental Services Limited | Water & waste | 2017 |
| Wearmouth Colliery Welfare | Arts & recreation | 1992 |