| Rivet and Rome Ltd | Wholesale & retail | 2025 |
| Riya Caterers Limited | Hospitality | 2009 |
| Rizq Real Estates Ltd | Real estate | 2021 |
| RKD Cleaning and Maintenance Ltd | Administrative & support | 2017 |
| RKD Domestic Cleaning Ltd | Other services | 2022 |
| Rkshah Ltd | Professional & scientific | 2026 |
| RLB Safeguarding Ltd | Public administration | 2022 |
| Rlrc Ltd | Arts & recreation | 2025 |
| RLT Property Developments Ltd | Real estate | 2020 |
| RLT Property Investment Ltd | Construction | 2020 |
| RM Roundhouse Ltd | Construction | 2023 |
| RMA Events Limited | Hospitality | 2025 |
| RNS Bookkeeping Services Ltd | Professional & scientific | 2022 |
| Roaming Robots Limited | Arts & recreation | 2011 |
| Robert Tutt & Sons Ltd | Construction | 2026 |
| Robots XR Ltd | Arts & recreation | 2024 |
| Rocka Southsea Ltd | Hospitality | 2025 |
| Rockbow Ltd | Construction | 2017 |
| Rocket From the Crypto Ltd | Information & communication | 2021 |
| Rocking Services UK Ltd | Hospitality | 2026 |
| ROD at Soul Bar Limited | Hospitality | 2026 |
| Roharya Properties Ltd | Real estate | 2026 |
| Rolay & Mano Ventures Ltd | Transport & logistics | 2025 |
| Rooftops Carpentry Ltd | Construction | 2023 |
| ROOMS4DAYS Ltd | Households | 2021 |
| Rootstitch Ltd | Wholesale & retail | 2026 |
| Rosa Driving School Ltd | Education | 2026 |
| Rosary Management Company Limited | Households | 1993 |
| Rose Clover Limited | Wholesale & retail | 2014 |
| Rose of Jericho Services Limited | Professional & scientific | 2015 |
| Rosebay Developments Limited | Real estate | 2012 |
| Roskeen Court Farlington Management Limited | Households | 2009 |
| Rossmore House Limited | Households | 2011 |
| Rothon Analyte Ltd | Professional & scientific | 2020 |
| Rowlands Castle Construction (Southern) Limited | Construction | 2025 |
| RP Events and Hospitality Ltd | Arts & recreation | 2026 |
| RP Southsea Limited | Other services | 2010 |
| Rrjr Developments Ltd | Construction | 2023 |
| RS Top Store Ltd | Wholesale & retail | 2025 |
| Rtcooling Limited | Construction | 2018 |
| Rubixcodes Ltd | Information & communication | 2024 |
| Ruby Solutions Limited | Real estate | 2022 |
| Rubyfin Limited | Hospitality | 2010 |
| Rude Engineering Ltd. | Wholesale & retail | 2015 |
| Ruler Construction Limited | Construction | 2024 |
| Runr Limited | Wholesale & retail | 2016 |
| Rutendo RGN Ltd | Health & social care | 2018 |
| RWM Quality Limited | Professional & scientific | 2017 |
| Ryzup Limited | Manufacturing | 2026 |
| S & F Wallace Properties Limited | Real estate | 2017 |
| S & V Retail Ltd | Wholesale & retail | 2019 |
| S Bowers Construction Ltd | Construction | 2024 |
| S Golf Simulators Ltd | Arts & recreation | 2025 |
| S J P Site Welding Limited | Construction | 2007 |
| S T Southern Limited | Construction | 2008 |
| S&N Cartify Ltd | Wholesale & retail | 2026 |
| S-Ci Research Ltd | Information & communication | 2024 |
| S.C.H Site Management Limited | Construction | 2020 |
| S.Musson Plumbing Services Ltd | Construction | 2015 |
| S.U.I. Limited | Information & communication | 2000 |
| S2 Developments Ltd | Construction | 2010 |
| S2A Portsmouth Ltd | Hospitality | 2025 |
| S5 Security Services Ltd | Administrative & support | 2022 |
| Sabor Latino Ltd | Arts & recreation | 2023 |
| Saen Medical Ltd | Health & social care | 2018 |
| Saferx Ltd | Information & communication | 2025 |
| Safi & Khan Ltd | Professional & scientific | 2025 |
| Sagawood Limited | Households | 1998 |
| Sail Youth Theatre Academy Ltd | Arts & recreation | 2024 |
| Salar Abdullah Ltd | Wholesale & retail | 2026 |
| Salisbury Road Group Ltd | Households | 2015 |
| Sallysalvages Limited | Manufacturing | 2021 |
| Salter & Bond Limited | Manufacturing | 2003 |
| Salty Pebble Apartments Ltd | Real estate | 2026 |
| Saman Portsmouth Limited | Hospitality | 2025 |
| Samarch Ltd | Real estate | 2021 |
| Sancak Cafe Ltd | Hospitality | 2021 |
| Sand Coffee Ltd | Hospitality | 2025 |
| Sandhurst Residents Limited | Hospitality | 1991 |
| Sandpiper Associates Limited | Professional & scientific | 2011 |
| Sands Courier Services Ltd | Transport & logistics | 2025 |
| Sarah Robertson Holdings Limited | Financial services | 2020 |
| Saratou Ltd | Health & social care | 2019 |
| Sarisbury Healthcare Ltd | Health & social care | 2022 |
| Savage Star Ltd | Information & communication | 2024 |
| Savhfresh Ltd | Information & communication | 2025 |
| Savvvy Cosmetics Limited | Manufacturing | 2025 |
| Sawkins Ltd | Transport & logistics | 2026 |
| Sbhs Holdings Ltd | Financial services | 2023 |
| Sbmp Limited | Other services | 2018 |
| SBS Certified Public Accountants Ltd | Professional & scientific | 2016 |
| SC Properties Limited | Real estate | 2026 |
| Scandi Lettings Ltd | Real estate | 2021 |
| Scanfile(Gb)Ltd | Professional & scientific | 2005 |
| Scar Solars Ltd | Energy | 2025 |
| SCG Services Ltd | Health & social care | 2019 |
| Scimitar International Limited | Wholesale & retail | 2001 |
| SCM Accountants Ltd | Professional & scientific | 2013 |
| Scma (South) Ltd | Professional & scientific | 2008 |
| Scma Limited | Professional & scientific | 2003 |