| Draft Cargoways UK Ltd | Transport & logistics | 2025 |
| Draftwright Ltd | Professional & scientific | 2025 |
| Dragnea FM Ltd | Transport & logistics | 2023 |
| Dragon Armoury Ltd | Arts & recreation | 2019 |
| Dragon's DEN (Soton) Ltd | Hospitality | 2026 |
| Dragon's DEN (Woolston) Ltd | Hospitality | 2024 |
| Dragonfly FX Ltd | Professional & scientific | 2021 |
| Dragonfly Labs Limited | Professional & scientific | 2021 |
| Dragonfly Rubbish Removals Ltd | Water & waste | 2024 |
| Dragons WOK Ltd | Hospitality | 2025 |
| Dragos Driving Limited | Transport & logistics | 2013 |
| Drain Free Maintenance Ltd | Water & waste | 2002 |
| Drain Rescue Limited | Construction | 2016 |
| Drake Brothers Ltd | Wholesale & retail | 2026 |
| Drake Holdings Limited | Real estate | 2025 |
| Draken Pubs Ltd | Hospitality | 2025 |
| Drakes Court (Marchwood) Management Company Limited | Administrative & support | 1994 |
| Dray Team Ltd | Transport & logistics | 2023 |
| Drayback Limited | Information & communication | 2024 |
| Drayton Homes Limited | Construction | 2020 |
| DRC Deli Limited | Hospitality | 2023 |
| DRC Topco Limited | Financial services | 2025 |
| Dream Car Trader Ltd | Wholesale & retail | 2016 |
| Dream Day Campers Limited | Wholesale & retail | 2017 |
| Dream Empire Events Ltd | Administrative & support | 2021 |
| Dream Homes PVT Ltd | Real estate | 2020 |
| Dream Nest Property Ltd | Real estate | 2024 |
| Dream Place Home Southampton Ltd | Real estate | 2022 |
| Dream Rent Properties Ltd | Real estate | 2022 |
| Dream Smiles Limited | Health & social care | 2012 |
| Dreamco Limited | Wholesale & retail | 2025 |
| Dreamhills II G&F Ltd | Health & social care | 2016 |
| Dreams Healthcare Limited | Health & social care | 2015 |
| Dreamscape Surroundings Ltd | Administrative & support | 2023 |
| Dreamville Builders Limited | Construction | 2026 |
| Drew Inn Ltd | Hospitality | 2009 |
| Dribble Creative Limited | Professional & scientific | 2016 |
| Dries Supported Living Services Ltd | Health & social care | 2006 |
| Drift Aesthetics Ltd | Other services | 2026 |
| Drilian Ltd | Transport & logistics | 2016 |
| Drinks Discovered Ltd | Wholesale & retail | 2020 |
| Drip'D Burger & Co Ltd | Hospitality | 2025 |
| Dripool Limited | Manufacturing | 1994 |
| Dripset Clothing Ltd | Wholesale & retail | 2021 |
| Drip’D & Co Lettings Ltd | Real estate | 2025 |
| Drive & Dine Academy Ltd | Manufacturing | 2019 |
| Drive and Explore Ltd | Education | 2023 |
| Drive My CAB Ltd | Transport & logistics | 2025 |
| Drive N Deliver 4 U Ltd | Transport & logistics | 2025 |
| Drive Personnel Limited | Administrative & support | 2023 |
| Drive Personnel Managed Services Limited | Administrative & support | 2024 |
| Drive Urban Ltd | Administrative & support | 2024 |
| Drive With Confidence Ltd | Education | 2025 |
| Drivenowpayweekly Limited | Administrative & support | 2025 |
| Driver Side Solutions Limited | Transport & logistics | 2024 |
| Driving School of Southampton Ltd | Education | 2025 |
| Drivingtestswap Ltd | Information & communication | 2025 |
| DRJ Electrical Ltd | Construction | 2024 |
| Drjl Construction Ltd | Construction | 2022 |
| DRL Brickwork Limited | Construction | 2004 |
| DRM Installations Ltd | Construction | 2011 |
| DRM19 Limited | Transport & logistics | 2019 |
| Dromeas Yachts International Limited | Administrative & support | 2021 |
| Drone Revelation Ltd | Professional & scientific | 2020 |
| Drop Box Home Delivery Solutions Ltd | Manufacturing | 2020 |
| Droplet Scientific Ltd | Manufacturing | 2022 |
| Drops Full Logistics Ltd | Water & waste | 2024 |
| Drovetech Limited | Wholesale & retail | 2010 |
| Droxford Community Hub CIC | Other services | 2019 |
| Droxford Developments Limited | Construction | 2018 |
| Droxford Montessori School Limited | Education | 2013 |
| DRT Holdings Limited | Professional & scientific | 2005 |
| Drummond Read Associates Ltd | Administrative & support | 2000 |
| Drury Property Ltd | Real estate | 2026 |
| DRW Distribution Ltd | Wholesale & retail | 2016 |
| Drycool Engineering Systems Ltd | Manufacturing | 2010 |
| Drystack Limited | Professional & scientific | 2001 |
| Drywall Taping Ltd | Construction | 2020 |
| Dr’S Social Help Ltd | Health & social care | 2023 |
| DS Agri Ltd | Agriculture & fishing | 2026 |
| DS Builders (South) Ltd | Construction | 2009 |
| DS Home Investments Ltd | Real estate | 2023 |
| DS Professional Services UK Limited | Information & communication | 2003 |
| DS Property Services (Southern) Ltd | Administrative & support | 1999 |
| DS Woodbury Ltd | Professional & scientific | 2019 |
| Ds:Uk Tribute Limited | Information & communication | 2023 |
| DSB Homes Limited | Real estate | 2024 |
| DSG Car Sales Ltd | Wholesale & retail | 2020 |
| DSG Glazing Systems Limited | Construction | 2014 |
| DSG Leone Limited | Transport & logistics | 2022 |
| DSG Transport Ltd | Transport & logistics | 2023 |
| DSH Property Maintenance Services Limited | Construction | 2018 |
| DSI Automotive Ltd | Manufacturing | 2018 |
| DSJ Glasshouse Services Ltd | Construction | 2009 |
| DSL Landscapes Ltd | Administrative & support | 2024 |
| Dsmstore Limited | Information & communication | 2025 |
| Dsrfoods Limited | Hospitality | 2025 |
| Dsru Education & Research Limited | Education | 2001 |
| Dsrvm Limited | Information & communication | 2026 |
| DST Real Estates Ltd | Real estate | 2024 |