| Waverley Lodge RTM Company Limited | Households | 2025 |
| Waves Cleaning Ltd | Administrative & support | 2025 |
| WAW Management Ltd | Real estate | 2021 |
| Waxon Consultants Ltd | Information & communication | 2024 |
| Waxy Ears Limited | Health & social care | 2021 |
| Way Ahead Leisure Pursuits Holding Ltd | Financial services | 2018 |
| Way Ahead Leisure Pursuits Ltd | Health & social care | 2012 |
| Way to Zero Limited | Professional & scientific | 2022 |
| Wayas Counselling and Training CIC | Health & social care | 2023 |
| Waybarn Holdings Limited | Real estate | 2020 |
| Waygrange Limited | Construction | 1978 |
| Wayman Associates Limited | Information & communication | 2015 |
| Wayment Infrastructure Consulting Limited | Professional & scientific | 2024 |
| Wayne Batten Boxing Management Limited | Arts & recreation | 2023 |
| Waynefleet Limited | Information & communication | 1986 |
| Waypoint Enterprises Ltd | Administrative & support | 2017 |
| Waypoint Events Limited | Hospitality | 2007 |
| Waypoint Support Services Ltd | Health & social care | 2025 |
| Waysgoose Limited | Administrative & support | 2010 |
| Wayside Holdings Limited | Real estate | 1947 |
| Waystar Securities Limited | Hospitality | 2023 |
| Wazer Ltd | Transport & logistics | 2024 |
| Waziri Ecommerce Limited | Wholesale & retail | 2024 |
| Waziri Enterprises Ltd | Hospitality | 2015 |
| WB Civil & Mechanical Holdings Limited | Financial services | 2020 |
| WB Civil & Mechanical Limited | Construction | 2014 |
| WBL Ventures Limited | Financial services | 2024 |
| WBM Service Limited | Wholesale & retail | 2012 |
| WBN2024 Ltd | Professional & scientific | 2015 |
| Wc&P Limited | Hospitality | 2014 |
| Wcorp Ltd | Other services | 2023 |
| WCS Solutions Ltd | Extraterritorial | 2012 |
| WE ARE Collision Studio Ltd | Professional & scientific | 2024 |
| WE ARE Innovative Consultancy Ltd | Information & communication | 2017 |
| WE ARE Locksmiths Limited | Wholesale & retail | 2010 |
| WE ARE Players Ltd | Hospitality | 2025 |
| WE ARE Soma Limited | Professional & scientific | 2020 |
| WE Buy Anime UK Ltd | Wholesale & retail | 2021 |
| WE CAN Train Limited | Education | 2020 |
| WE Care Together Southampton Limited | Health & social care | 2019 |
| WE Create Work Ltd | Education | 2019 |
| WE FIX Southampton Ltd | Construction | 2026 |
| WE LET Management Services Limited | Real estate | 2016 |
| WE Make Southampton CIC | Information & communication | 2016 |
| WE Skate Soton CIC | Arts & recreation | 2023 |
| WE UC Ltd | Information & communication | 2023 |
| WE Wheel FIX IT Limited | Wholesale & retail | 2016 |
| Weathermaster Home Improvements Ltd | Construction | 2015 |
| Weaver & LEE Ltd | Real estate | 2018 |
| Weavewell Ltd | Professional & scientific | 2013 |
| Web Design Southampton Limited | Professional & scientific | 2016 |
| Web Development and Solutions Limited | Information & communication | 2019 |
| Web Extreme Links Ltd | Information & communication | 2024 |
| Web Offer Marketing Limited | Wholesale & retail | 2000 |
| Web Refine Ltd | Information & communication | 2024 |
| Webadelica Ltd | Information & communication | 2013 |
| Webb Computer Solutions Ltd | Information & communication | 2004 |
| Webb House (Park Gate) Ltd | Real estate | 2022 |
| Webb Networks Ltd | Information & communication | 2019 |
| Webbs Green Stables Limited | Agriculture & fishing | 2018 |
| Webb’S Metal Recycling Limited | Water & waste | 2019 |
| Webcrypted Ltd | Information & communication | 2015 |
| Weblight Electrical Projects Ltd | Construction | 2015 |
| Webmark Solutions Ltd | Wholesale & retail | 2024 |
| Webpharmahub Limited | Wholesale & retail | 2024 |
| Webuyanybusiness Limited | Professional & scientific | 2022 |
| Webwave Ltd | Information & communication | 2025 |
| Webweavers Web Development Ltd | Information & communication | 2024 |
| Weclick Media Ltd | Information & communication | 2006 |
| Wedderburn Retail Solutions Limited | Construction | 2008 |
| Wedderburn Shop Fitting Limited | Construction | 1965 |
| Wedding Dress Alterations London Limited | Other services | 2018 |
| Wedding Dress Cleaners Ltd | Other services | 2016 |
| Wedeman Consulting Ltd | Professional & scientific | 2010 |
| Wedmet Trading Limited | Wholesale & retail | 2022 |
| Wedrivecars Ltd | Transport & logistics | 2025 |
| WEE Properties Holdings Ltd | Hospitality | 2025 |
| WEE Properties Ltd | Hospitality | 2025 |
| Weeguy Ltd | Construction | 2021 |
| Weekend S.O.S. Ltd | Manufacturing | 2024 |
| Wefix Portsmouth Ltd | Construction | 2026 |
| Wefix Winchester Ltd | Construction | 2026 |
| Wefuture Education & Travel Ltd | Administrative & support | 2018 |
| Weightwash Limited | Other services | 1966 |
| Weiss Logistics Limited | Transport & logistics | 2021 |
| Weiway Floral Ltd | Education | 2025 |
| Welbeck Pictures Limited | Information & communication | 2024 |
| Welborne Business Park Limited | Real estate | 2022 |
| Welborne Football Club Ltd | Arts & recreation | 2025 |
| Welborne Property Holdings Ltd | Financial services | 2022 |
| Welborne Self Storage Ltd | Other services | 2021 |
| Welburn & Co Limited | Professional & scientific | 2006 |
| Weld & Metalcraft (Holdings) Limited | Financial services | 2013 |
| Weldarolla ENG Services Ltd. | Manufacturing | 2015 |
| Weldepend Ltd | Professional & scientific | 2021 |
| Weldesign Limited | Professional & scientific | 2000 |
| Welding LAB Ltd | Manufacturing | 2026 |
| Welham Aviation Group Ltd | Professional & scientific | 2025 |
| Well Planned Ltd | Professional & scientific | 2024 |
| WELL24 Ltd | Wholesale & retail | 2025 |