| Southampton QE2 Hotel Limited | Hospitality | 2011 |
| Southampton Removals and Storage Limited | Professional & scientific | 1998 |
| Southampton Reptile Ltd | Wholesale & retail | 2015 |
| Southampton Retail Services Ltd | Hospitality | 2016 |
| Southampton Roast Co Ltd | Manufacturing | 2024 |
| Southampton Sailing Club Limited | Arts & recreation | 1970 |
| Southampton Sailing Limited | Transport & logistics | 2009 |
| Southampton Science Park Limited | Real estate | 1998 |
| Southampton Scrap Metal Limited | Water & waste | 2022 |
| Southampton Services Limited | Energy | 2008 |
| Southampton Short Breaks Ltd | Hospitality | 2019 |
| Southampton Short Stays Ltd | Hospitality | 2024 |
| Southampton Smart Park & Cruise Limited | Transport & logistics | 2026 |
| Southampton Special Purpose Workshop Limited | Health & social care | 2004 |
| Southampton Sports Bar Limited | Hospitality | 2013 |
| Southampton Street Pastors | Health & social care | 2010 |
| Southampton Taxis Hire Limited | Transport & logistics | 2021 |
| Southampton Taxis Ltd | Transport & logistics | 2026 |
| Southampton Tenants Union Limited | Other services | 2023 |
| Southampton Top Properties Ltd | Real estate | 2025 |
| Southampton Trading Ltd | Hospitality | 2023 |
| Southampton Training and Exams Limited | Education | 2021 |
| Southampton Transport Ltd | Transport & logistics | 2011 |
| Southampton Truck and Van Rental Limited | Administrative & support | 2016 |
| Southampton Ukrainian Community Support Group C.I.C. | Extraterritorial | 2022 |
| Southampton Voluntary Services | Other services | 1998 |
| Southampton Water Adventure Centre Ltd | Education | 2025 |
| Southampton Waters Yacht Sales Ltd | Administrative & support | 2009 |
| Southampton Waters Yacht Services Limited | Extraterritorial | 2009 |
| Southampton Westquay Coffee Limited | Hospitality | 2025 |
| Southampton Wood Recycling | Water & waste | 2012 |
| Southampton Woolston Coffee Limited | Hospitality | 2017 |
| Southamptonrestraunts Limited | Hospitality | 2026 |
| Southamptonstone Ltd | Manufacturing | 2024 |
| Southbrook Rise RTM Company Limited | Households | 2021 |
| Southcab Ltd | Transport & logistics | 2020 |
| Southcliff Flats Residents Association Limited | Hospitality | 1984 |
| Southcoast Automotive Services Ltd | Wholesale & retail | 2017 |
| Southcoast Building Company Ltd | Construction | 2019 |
| Southcoast Carpentry Ltd | Construction | 2019 |
| Southcoast Drive Revive Limited | Construction | 2018 |
| Southcoast Driveways & Roofing Ltd | Construction | 2024 |
| Southcoast Fascias & Roofing Ltd | Construction | 2023 |
| Southcoast Hardware and Plumbing Store Ltd | Wholesale & retail | 2025 |
| Southcoastcampervanhire Limited | Administrative & support | 2025 |
| Southcoastcare Ltd | Health & social care | 2026 |
| Southcoastcleaning Limited | Administrative & support | 2025 |
| Southcoastcleans Ltd | Administrative & support | 2026 |
| SOUTHCOASTELECTRICSCOOTERS285 Limited | Wholesale & retail | 2023 |
| Southcore Fibre Limited | Extraterritorial | 2022 |
| Southcott Estates Limited | Construction | 2014 |
| Southcott Haulage Services Limited | Transport & logistics | 2021 |
| Southcott Homes (Fareham) Limited | Construction | 2014 |
| Southcyclescustoms Limited | Wholesale & retail | 2023 |
| Southern Beacon Limited | Hospitality | 2007 |
| Southern Brave Limited | Arts & recreation | 2019 |
| Southern Bridge Solutions Ltd | Administrative & support | 2024 |
| Southern Building Investments Ltd | Financial services | 2016 |
| Southern Building Management Limited | Administrative & support | 2014 |
| Southern Business Computer Solutions Limited | Information & communication | 2001 |
| Southern Calibration Laboratories Limited | Professional & scientific | 1990 |
| Southern Carpentry Group Ltd | Construction | 2021 |
| Southern Chicken Limited | Hospitality | 2024 |
| Southern Cleaning Solutions Limited | Administrative & support | 2011 |
| Southern Coating Contractors Limited | Construction | 1993 |
| Southern Concrete Limited | Construction | 2007 |
| Southern County Trailers Ltd | Administrative & support | 2024 |
| Southern Cross Associates Limited | Households | 1998 |
| Southern Cross Carpentry and Building Limited | Construction | 2018 |
| Southern Cutting Tools Ltd | Manufacturing | 2026 |
| Southern Delivery Limited | Transport & logistics | 2025 |
| Southern Development Consultants Limited | Professional & scientific | 2024 |
| Southern Diabetes Medical Services LLP | | 2010 |
| Southern Dog School Limited | Other services | 2015 |
| Southern Domestic Energy Assessors Limited | Administrative & support | 2017 |
| Southern Eco Solutions Ltd | Wholesale & retail | 2019 |
| Southern Electrics Ltd | Construction | 2014 |
| Southern Event Power Limited | Energy | 2019 |
| Southern Family Mediation Limited | Other services | 2014 |
| Southern Glass Services (Hampshire) Limited | Manufacturing | 2010 |
| Southern Green Energy Group Limited | Construction | 2023 |
| Southern Ground Care Ltd | Administrative & support | 2012 |
| Southern Guttering Solutions Limited | Construction | 2013 |
| Southern Hampshire Estates Limited | Real estate | 1969 |
| Southern Hampshire Homes Limited | Real estate | 2026 |
| Southern Heat Solutions Ltd | Construction | 2016 |
| Southern Hydro Centre Limited | Wholesale & retail | 2003 |
| Southern Hygienic Coatings Limited | Professional & scientific | 2021 |
| Southern IT Solutions Group Limited | Information & communication | 2013 |
| Southern LA Vita Limited | Hospitality | 2018 |
| Southern Maritime Services Limited | Transport & logistics | 2005 |
| Southern Multi Trade Ltd | Construction | 2026 |
| Southern Nature Art CIC | Wholesale & retail | 2024 |
| Southern Payroll Solutions Ltd | Other services | 2024 |
| Southern Print Finishing Solutions Limited | Manufacturing | 2025 |
| Southern Property Maintenance Ltd | Construction | 2020 |
| Southern Protective Coatings Limited | Construction | 2022 |
| Southern Pubs and Hotels Ltd | Hospitality | 2023 |
| Southern Roof Diagnostics Ltd | Construction | 2026 |
| Southern Roofing Ltd | Construction | 2019 |