| Shahinaj Limited | Hospitality | 2022 |
| Shahini Limited | Hospitality | 2026 |
| Shahinovsky Ltd | Transport & logistics | 2025 |
| Shahziz Ltd | Wholesale & retail | 2024 |
| Shaj Ltd | Transport & logistics | 2019 |
| Shakenzy Limited | Wholesale & retail | 2026 |
| Shaker Estates Limited | Other services | 2020 |
| Shalico Limited | Construction | 2017 |
| Sham Transport Limited | Transport & logistics | 2026 |
| Shami Health Care Ltd | Public administration | 2025 |
| Shane Court Residents Company Limited | Households | 1974 |
| Shane Dixon Limited | Construction | 2015 |
| Shane Jennings Limited | Administrative & support | 2016 |
| Shanee Ltd | Wholesale & retail | 2023 |
| Shang HAI Star Food U.K Limited | Wholesale & retail | 2019 |
| Shang Holdings Ltd | Real estate | 2019 |
| Shanghai Bay 888 Limited | Hospitality | 2018 |
| Shanghai LAN Limited | Administrative & support | 2015 |
| Shanley Recruitment Services Ltd | Administrative & support | 2024 |
| Shannon Family Investments Limited | Construction | 2021 |
| Shanti Associates Limited | Health & social care | 2011 |
| Shanto IT Firm Ltd | Information & communication | 2024 |
| Shaping Landscapes Ltd | Professional & scientific | 2026 |
| Shapton Ventures Ltd | Financial services | 2026 |
| Shard Global Sales Ltd | Wholesale & retail | 2018 |
| Share 2 Care Ltd | Health & social care | 2021 |
| Shared Ventures Limited | Professional & scientific | 2015 |
| Sharefront Property Management Limited | Households | 1998 |
| Shari Properties Ltd | Real estate | 2023 |
| Shark Design & Build Ltd | Construction | 2025 |
| Shark Vape Supplier Ltd | Wholesale & retail | 2025 |
| Shark Wash Ltd | Administrative & support | 2023 |
| Sharma's Cafe on Wheels Ltd | Wholesale & retail | 2023 |
| Sharon Eyre Property Limited | Households | 2019 |
| Sharp CUT Barbers Hythe Ltd | Other services | 2026 |
| Sharp FIX Aesthetics Ltd | Health & social care | 2020 |
| Sharp FIX Aesthetics South Ltd | Health & social care | 2023 |
| Sharpe's Electrical Services Limited | Construction | 2021 |
| Sharratt Brothers Ltd | Wholesale & retail | 2020 |
| Sharujan Limited | Wholesale & retail | 2024 |
| Shasta Pet Ltd | Wholesale & retail | 2026 |
| Shaun Hilton Training and Consultancy Ltd | Education | 2022 |
| Shaun L Williams Ltd | Transport & logistics | 2021 |
| Shaw Trading Ltd | Administrative & support | 2013 |
| Shawais Group Limited | Wholesale & retail | 2024 |
| Shawfix Autos Ltd | Wholesale & retail | 2010 |
| Shawford Capital Limited | Real estate | 2013 |
| Shawplus Ltd | Wholesale & retail | 2024 |
| Shawstone House Limited | Professional & scientific | 2018 |
| Shayaan Investments Ltd | Real estate | 2025 |
| Shayona UK Ltd | Wholesale & retail | 2003 |
| Shaz ESSENTIALS0786 Ltd | Wholesale & retail | 2025 |
| SHB Marine Ltd | Manufacturing | 2025 |
| Shears Landscaping Ltd | Construction | 2021 |
| Shedfield Equestrian Limited | Agriculture & fishing | 2024 |
| Shedfield Properties Limited | Professional & scientific | 2024 |
| Shedfield Recycling Limited | Professional & scientific | 2015 |
| Sheefo Composites Ltd | Professional & scientific | 2023 |
| Sheenay Ltd | Wholesale & retail | 2023 |
| Sheerspire Holdings Limited | Real estate | 2017 |
| Sheikabusi Limited | Financial services | 2016 |
| Shellcroft Associates Limited | Professional & scientific | 2010 |
| Shelley Construction Services Limited | Construction | 2022 |
| Shelley Court Management Company (Southampton) Limited | Households | 1987 |
| Shellyann Ltd | Health & social care | 2022 |
| Shelter and Shade Awnings Ltd | Other services | 2006 |
| Shenhwa International Education Links Limited | Education | 2016 |
| Shepard Investments Limited | Administrative & support | 2019 |
| Shepherds Holdings Limited | Real estate | 2024 |
| Shepherds Inn Southampton Ltd | Hospitality | 2019 |
| Sheppard Commercial Services Limited | Wholesale & retail | 2000 |
| Sheppard Recovery Services Ltd | Wholesale & retail | 2020 |
| Sheppard Transport Services Ltd | Transport & logistics | 2025 |
| Sheppards Hospitality Ltd | Hospitality | 2025 |
| Sheq Nexus Consultants Ltd | Professional & scientific | 2024 |
| Sheraz Enterprises Ltd | Wholesale & retail | 2024 |
| Sherfield Homes Limited | Construction | 2024 |
| Shergill Consultancy Ltd | Administrative & support | 2024 |
| Shergill Estates Property Development Limited | Real estate | 2015 |
| Shergill Estates Property Lettings Ltd | Real estate | 2018 |
| Shergold Investments Limited | Real estate | 1972 |
| Sheridan Akers Consulting Limited | Professional & scientific | 2006 |
| Sheriol Thirty - Two Limited | Real estate | 1992 |
| Sherls Ltd | Health & social care | 2015 |
| Sherpa 63 Ltd | Professional & scientific | 2016 |
| Sherry Homes Ltd | Real estate | 2017 |
| Sherwin N&S Ltd | Education | 2024 |
| Sherwin Technology Ltd | Information & communication | 2025 |
| Shesa-Nyama 1 Limited | Hospitality | 2025 |
| Sheung Moon Ltd | Hospitality | 2023 |
| Shewan Services Limited | Construction | 2013 |
| Shibhavin Limited | Hospitality | 2025 |
| Shield Building Developments Ltd | Construction | 2009 |
| Shield Building Services (UK) Limited | Construction | 2010 |
| Shield Cars Limited | Wholesale & retail | 2022 |
| Shield Decorators & Spraying Specialists Ltd | Construction | 2014 |
| Shield Home Improvements Ltd | Construction | 2011 |
| Shield House Dentistry Limited | Health & social care | 2011 |
| Shield-Maiden Activewear Ltd | Wholesale & retail | 2020 |
| Shiemloenn Limited | Manufacturing | 2010 |