| SBS Lettings Ltd | Real estate | 2018 |
| SC Bedford Limited | Real estate | 2017 |
| SC Beny Trans Ltd | Transport & logistics | 2021 |
| SC Cosmetix Ltd | Other services | 2023 |
| SC Global Connect Ltd | Administrative & support | 2025 |
| SC Global Holdings Ltd | Real estate | 2022 |
| SC Interiors Limited | Construction | 2025 |
| SC Jewellers Ltd | Other services | 2025 |
| SC Mines Limited | Mining & quarrying | 2017 |
| SC Owen Limited | Real estate | 2017 |
| SC Questpit Limited | Construction | 2018 |
| SC Services Southern Ltd | Wholesale & retail | 2021 |
| Scaffold IT UK Limited | Construction | 2005 |
| Scalenorth Ventures Ltd | Wholesale & retail | 2023 |
| Scalerule Tenders and Estimates Limited | Professional & scientific | 2020 |
| Scallop Ranch Ltd | Agriculture & fishing | 2014 |
| Scallywags School for Dogs Ltd | Agriculture & fishing | 2017 |
| Scan and Remember Ltd | Professional & scientific | 2023 |
| Scarab Solutions Ltd | Agriculture & fishing | 2015 |
| Scarless Surgery Limited | Health & social care | 2011 |
| Scates-Properties Ltd | Real estate | 2025 |
| Scatterbrook Limited | Real estate | 2026 |
| SCC 2005 Limited | Construction | 2005 |
| SCC 2024 Limited | Construction | 2024 |
| Sccq Limited | Wholesale & retail | 2026 |
| SCD Consultancy Services Ltd | Information & communication | 2015 |
| SCG Medical Limited | Health & social care | 2025 |
| Schadébo UK Limited | Wholesale & retail | 2024 |
| Schebo Biotech UK Limited | Wholesale & retail | 1999 |
| Schema Health ML Ltd | Information & communication | 2026 |
| Schily&Alex Ltd | Transport & logistics | 2017 |
| Schmitt Limited | Other services | 2018 |
| School Outdoor Learning Ltd | Education | 2012 |
| Schoollift Ltd | Transport & logistics | 2026 |
| Schuster Group Ltd | Other services | 2016 |
| Scoop Route Ltd | Information & communication | 2026 |
| Scoops Gelato Limited | Extraterritorial | 2013 |
| Scoops Portswood Ltd | Hospitality | 2023 |
| Scorched Productions Limited | Other services | 2002 |
| Scorgies Limited | Transport & logistics | 2018 |
| Scorpion Structural Design Ltd | Professional & scientific | 2011 |
| Scorpios Services Ltd | Other services | 2020 |
| Scotmore Limited | Information & communication | 2007 |
| Scotney Salon Ltd | Other services | 2004 |
| Scott Beck Paving & Landscapes Limited | Construction | 2016 |
| Scott Housing Ltd | Real estate | 2021 |
| Scott Loveday Building & Paving Contractors Limited | Construction | 2014 |
| Scott Martin Carpets and Flooring Limited | Construction | 2014 |
| Scott Surridge Limited | Extraterritorial | 2006 |
| Scott-Otway LLP | | 2010 |
| Scouting for Solutions Ltd | Information & communication | 2024 |
| Scratchive Innovations Ltd | Information & communication | 2025 |
| Scream Events UK Ltd | Other services | 2023 |
| Screw Piling Supplies Limited | Construction | 2017 |
| Scribble Studio One Ltd | Wholesale & retail | 2025 |
| Script-It Limited | Information & communication | 2023 |
| Scrumptious Consultancy Limited | Professional & scientific | 2014 |
| Scrutiny Systems Limited | Administrative & support | 2016 |
| SCS Dorset Limited | Construction | 2019 |
| SCS Technologies Ltd | Information & communication | 1998 |
| SD Apartments Limited | Real estate | 2021 |
| SD Lighting Ltd | Arts & recreation | 2024 |
| SD Strategic Services Limited | Professional & scientific | 2026 |
| SDB Property Services Limited | Construction | 2018 |
| SDC Pioneer Limited | Manufacturing | 2019 |
| SDD Investments Limited | Construction | 2011 |
| SDF PA Services Ltd | Administrative & support | 2015 |
| SDI Hospitality Ltd | Hospitality | 2024 |
| SDI Property Investments Ltd | Real estate | 2024 |
| SDJ Construction Services Ltd | Professional & scientific | 2023 |
| SDM Facilities Ltd | Water & waste | 2023 |
| SDM Property Group Ltd | Real estate | 2024 |
| SDM Property Ltd | Real estate | 2019 |
| Sdmparking Ltd | Hospitality | 2023 |
| SDS Electrical and Maintenance Limited | Construction | 2013 |
| SDS Print Finishing Limited | Manufacturing | 2013 |
| SDS Roofing Services Limited | Construction | 2015 |
| SDW Enterprises Limited | Professional & scientific | 2009 |
| SDW Plastering Limited | Construction | 2016 |
| SDW Property Investments Limited | Real estate | 2020 |
| SDW Recovery Ltd | Transport & logistics | 2024 |
| Sea City Recruitment Limited | Administrative & support | 2014 |
| Sea Griffin Ltd | Professional & scientific | 2024 |
| Sea Squared Trading Limited | Financial services | 2015 |
| Sea Start Limited | Other services | 1999 |
| Sea Ventures (South Coast) Limited | Wholesale & retail | 2007 |
| Sea-Avia Forwarding Limited | Transport & logistics | 1998 |
| Sea-M Clothing Limited | Wholesale & retail | 2025 |
| Seabed Resources Development Limited | Professional & scientific | 2013 |
| Seaborn & Sons Ltd | Real estate | 2019 |
| Seacity Transfers Ltd | Transport & logistics | 2023 |
| Seafarers View LLP | | 2022 |
| Seafast Containers Limited | Transport & logistics | 2009 |
| Seafield Partners Limited | Health & social care | 2016 |
| Seafield Rentals Limited | Real estate | 2020 |
| Seagrave Metal Works Limited | Manufacturing | 1984 |
| Seahaven Holdings Limited | Financial services | 2020 |
| Seahaven Maritime Academy (Southern) Limited | Education | 2026 |
| Seal Bidco Limited | Financial services | 2017 |
| Seal Carpentry Ltd | Construction | 2026 |