| Restored and Modified Limited | Wholesale & retail | 2021 |
| Retail Allies Limited | Professional & scientific | 2016 |
| Retreat Group (Management) Limited | Administrative & support | 2020 |
| RF Marine Services Ltd | Manufacturing | 2019 |
| RGB Truck Services Limited | Financial services | 2020 |
| RGI Trim Services Limited | Manufacturing | 2020 |
| Richard Crosby Limited | Professional & scientific | 2010 |
| Rineys Ltd | Other services | 2021 |
| RIO8CREATION Limited | Wholesale & retail | 2017 |
| Riverview 2 Developments Limited | Other services | 2024 |
| RJ Management Services Ltd | Professional & scientific | 2015 |
| RM Frogley Fencing & Landscaping Limited | Construction | 2008 |
| Rock Hard Stuff Limited | Wholesale & retail | 2014 |
| Rock the Boat Limited | Information & communication | 2025 |
| Rockstud Consulting Limited | Professional & scientific | 2016 |
| Rockwood Tree and Gardens Ltd | Other services | 2021 |
| Roger Frogley & Sons Fencing Ltd | Construction | 2011 |
| Rogue Motorsport Ltd | Wholesale & retail | 1999 |
| Rooster Design Ltd | Information & communication | 2010 |
| Roots Tree Surgeons Limited | Administrative & support | 2017 |
| Rubyretail Ltd | Wholesale & retail | 2019 |
| Run Wild Ltd | Professional & scientific | 2025 |
| Rural Village Homes Limited | Construction | 2025 |
| Rutherford Medical Consultancy Ltd | Administrative & support | 2019 |
| RW Brickwork Contractors Limited | Construction | 2017 |
| RWM (Midlands) Limited | Construction | 2012 |
| S & H Property Development Limited | Construction | 2013 |
| S & L P Holding Limited | Financial services | 2021 |
| S & M Fencing and Landscaping Ltd | Administrative & support | 2022 |
| S Cummings Limited | Information & communication | 2006 |
| S Webb Consulting Limited | Professional & scientific | 2023 |
| SA Clarke Real Estate Limited | Real estate | 2023 |
| SA Horses Limited | Agriculture & fishing | 2023 |
| Sabi and Saint Limited | Professional & scientific | 2023 |
| Sabi Insight Ltd | Professional & scientific | 2021 |
| Sach Consulting Limited | Information & communication | 2022 |
| Saddlestone Limited | Manufacturing | 2023 |
| Safety Pass Alliance (Spa) Ltd. | Other services | 2000 |
| Saieva Telecoms Ltd | Professional & scientific | 2023 |
| Sales Eagle Limited | Professional & scientific | 2012 |
| Salgar UK Limited | Manufacturing | 2023 |
| Salto Systems Limited | Other services | 2013 |
| Samba Homes Ltd | Real estate | 2024 |
| Sampos Engineering LLP | | 2018 |
| Sandra's Flower Studio Limited | Wholesale & retail | 2020 |
| Sapient Design Solutions Limited | Administrative & support | 2009 |
| Savannah Projects Limited | Administrative & support | 2011 |
| Sawyerr Peters Removals and Storage Ltd | Transport & logistics | 2008 |
| SB Vitality Limited | Wholesale & retail | 2023 |
| Scarlett Red Recruitment Limited | Administrative & support | 2008 |
| Scotcan Property Holdings Limited | Real estate | 2023 |
| Sdht Services Ltd | Health & social care | 2018 |
| Sebella Homes Construction Limited | Construction | 2025 |
| Sector Marketing Ltd | Professional & scientific | 2023 |
| Seecam Limited | Administrative & support | 2001 |
| SEK JPM Management Limited | Professional & scientific | 2017 |
| Sendient Limited | Information & communication | 2022 |
| Senzati Limited | Manufacturing | 2014 |
| SES Partnership LLP | | 2025 |
| SGS & Co Accountants & Business Consultants Limited | Professional & scientific | 2016 |
| SGS & Partners Group Ltd | Professional & scientific | 2021 |
| Sgsh Commercial Cleaning Limited | Administrative & support | 2025 |
| Shama Helps YOU Limited | Extraterritorial | 2021 |
| Sheridan Projects Limited | Manufacturing | 2026 |
| Shuriken Limited | Real estate | 2016 |
| Sierra Bravo Limited | Professional & scientific | 2017 |
| Silent Surfaces Ltd | Construction | 2024 |
| Silson Limited | Manufacturing | 1994 |
| Silverdale Villettes Limited | Real estate | 1966 |
| Silverstone Builders Limited | Construction | 1974 |
| Simker Limited | Information & communication | 2025 |
| Simply Advanced Limited | Construction | 2011 |
| Simply MLC Ltd | Wholesale & retail | 2025 |
| Site Safety Group Limited | Professional & scientific | 2024 |
| Skelcher Holdings Limited | Financial services | 2017 |
| Skerratt Holdings Ltd | Real estate | 2026 |
| Skyline Property Group Ltd | Households | 2025 |
| SL Billing Ltd | Professional & scientific | 2024 |
| SL Investment Properties Ltd | Real estate | 2026 |
| Sleephalo Direct Limited | Manufacturing | 2021 |
| Slic Solutions Limited | Professional & scientific | 2011 |
| Slips on Site Limited | Construction | 2017 |
| Small Servers Ltd. | Information & communication | 2020 |
| Smartassessor Limited | Information & communication | 2025 |
| Smartcom Solutions Limited | Manufacturing | 2000 |
| Smarteducator Labs Limited | Information & communication | 2025 |
| Smartrepairuk Ltd | Wholesale & retail | 2025 |
| Smuckie's Limited | Manufacturing | 2018 |
| SNC Studios Limited | Information & communication | 2023 |
| Snctuary Ltd | Wholesale & retail | 2023 |
| SO HEY Limited | Wholesale & retail | 2016 |
| Sola Marketing Limited | Professional & scientific | 2025 |
| Somi Bakes Ltd | Manufacturing | 2025 |
| Sonic Fuel Ltd | Information & communication | 2024 |
| Southam Bodies Ltd | Wholesale & retail | 2022 |
| Southam Business Community CIC | Other services | 2023 |
| Southam Church and Community Project Ltd | Other services | 2005 |
| Southam Cleaning Services Limited | Administrative & support | 2026 |
| Southam Financial Planning Ltd | Professional & scientific | 2014 |
| Southam Gateway Coffee Shop Ltd | Hospitality | 2011 |