| Somali Language Interpreting & Community Services Limited | Other services | 2011 |
| Somali Simma: Education, Culture, and Skills for the Deaf | Other services | 2021 |
| Somerset Poppies Ltd | Wholesale & retail | 2022 |
| Somet Travel Limited | Administrative & support | 2025 |
| Somraj Building Contractors Ltd | Construction | 2025 |
| Sona BHI Spice Limited | Hospitality | 2017 |
| Sona Builders Ltd | Construction | 2020 |
| Soni Boutique Limited | Other services | 2023 |
| Soni Fresh Produce Limited | Wholesale & retail | 2023 |
| Sonia Beauty and Hair Ltd | Other services | 2026 |
| Sonia Construction Limited | Construction | 2025 |
| Sonia Technologies UK Ltd | Information & communication | 2025 |
| Soniatyagi Enterprise Limited | Construction | 2025 |
| Sonikra Limited | Professional & scientific | 2022 |
| Sonnet Communications Limited | Wholesale & retail | 2017 |
| Sonny Transport Ltd | Transport & logistics | 2020 |
| Soodconstruction Limited | Construction | 2026 |
| Sopago Limited | Wholesale & retail | 2024 |
| Sophiemark Ltd | Wholesale & retail | 2023 |
| Soulstarz Ltd | Arts & recreation | 2022 |
| Soultaan Limited | Wholesale & retail | 2025 |
| Sounas Limited | Manufacturing | 1997 |
| Soundwaveslighting Ltd | Administrative & support | 2024 |
| Soundworks Ltd | Professional & scientific | 2005 |
| South Crescent Limited | Financial services | 2019 |
| South CUT Limited | Other services | 2015 |
| South Inn Limited | Hospitality | 2018 |
| South Road Convenience Store Ltd | Wholesale & retail | 2025 |
| Southall Afghan Bakery Limited | Wholesale & retail | 2016 |
| Southall Autos Ltd | Wholesale & retail | 2021 |
| Southall Bags & Luggage Ltd | Wholesale & retail | 2019 |
| Southall Banqueting Hall Limited | Hospitality | 2016 |
| Southall Business Units Ltd | Real estate | 2017 |
| Southall Cafe Ltd | Hospitality | 2025 |
| Southall Cakes Limited | Manufacturing | 2019 |
| Southall Car Care Center Ltd | Wholesale & retail | 2019 |
| Southall Car Centre Ltd | Wholesale & retail | 2023 |
| Southall Cash and Carry Limited | Wholesale & retail | 2018 |
| Southall Comms Ltd | Wholesale & retail | 2019 |
| Southall Community Alliance | Health & social care | 2002 |
| Southall Convenience Food Store Ltd | Wholesale & retail | 2020 |
| Southall Court (Lady Margaret Road) RTM Company Limited | Real estate | 2013 |
| Southall Department Store Ltd | Wholesale & retail | 2022 |
| Southall Deshi Bazar Ltd | Wholesale & retail | 2019 |
| Southall Designer Outlet Ltd | Wholesale & retail | 2015 |
| Southall Engines Limited | Wholesale & retail | 2017 |
| Southall Enterprise Business Park Limited | Real estate | 2016 |
| Southall Estate Agents (Lettings) Limited | Real estate | 2007 |
| Southall Estate Agents Limited | Real estate | 2003 |
| Southall Express Ltd | Wholesale & retail | 2025 |
| Southall Fabrics Limited | Wholesale & retail | 2024 |
| Southall FC Limited | Education | 2019 |
| Southall Food Market Ltd | Wholesale & retail | 2025 |
| Southall Football Club Ltd | Arts & recreation | 2018 |
| Southall Freshies Ltd | Wholesale & retail | 2025 |
| Southall Groceries Ltd | Wholesale & retail | 2025 |
| Southall Halal - Meat & Poultry Ltd | Wholesale & retail | 2026 |
| Southall Hand Carwash Ltd | Wholesale & retail | 2025 |
| Southall Herbals Ltd | Health & social care | 2024 |
| Southall Home Bargain Furniture Ltd | Wholesale & retail | 2022 |
| Southall Kitchen Limited | Hospitality | 2024 |
| Southall Local Ltd | Wholesale & retail | 2025 |
| Southall London Construction Group Ltd | Construction | 2023 |
| Southall London Glazing Ltd | Construction | 2018 |
| Southall Spice Ltd | Hospitality | 2024 |
| Southall Stores Ltd | Wholesale & retail | 2019 |
| Southall Tamil Association | Education | 2024 |
| Southall Travel Limited | Administrative & support | 1984 |
| Southern Slopes Limited | Wholesale & retail | 2025 |
| SP Constructors Ltd | Construction | 2025 |
| Spacemax Condos Ltd | Households | 2023 |
| Spares Hub Limited | Wholesale & retail | 2024 |
| Spark Events Limited | Hospitality | 2024 |
| Sparkeytech Limited | Professional & scientific | 2020 |
| Sparkle Decor Limited | Wholesale & retail | 2022 |
| Sparkx Courier Ltd | Transport & logistics | 2025 |
| Spawnify Limited | Wholesale & retail | 2024 |
| SPC Psychology Ltd | Education | 2022 |
| Speech Specialist Limited | Health & social care | 2023 |
| Speed's Juice UK Ltd | Wholesale & retail | 2017 |
| Speedtechlondon Ltd | Transport & logistics | 2025 |
| Speedup Runner Ltd | Transport & logistics | 2019 |
| Speedwell Transport Ltd | Transport & logistics | 2010 |
| Speedy Accounting Limited | Professional & scientific | 2025 |
| Speedy Cargo London Ltd | Transport & logistics | 2025 |
| Speedy Contractors Ltd | Construction | 2025 |
| Speedy Hammer Ltd | Construction | 2025 |
| Speedy Limited | Wholesale & retail | 2023 |
| Speedy Logistic Services Ltd | Transport & logistics | 2021 |
| Spencers Eco Installations Ltd | Construction | 2025 |
| Spencers Plumbing and Heating Ltd | Construction | 2019 |
| Spice Food Ltd | Hospitality | 2025 |
| Spice of Pakistan Ltd | Hospitality | 2025 |
| Spices M Services Ltd | Hospitality | 2023 |
| Spire Group Real Estate Ltd | Real estate | 2019 |
| Splashdeco Ltd | Construction | 2019 |
| Splitline 34 Ltd | Transport & logistics | 2014 |
| Spot Funding Limited | Financial services | 2019 |
| SPP Convenient Group Limited | Wholesale & retail | 2018 |
| Spray and Roll Ltd | Construction | 2023 |