| Sevenstar Luxury Leasing Ltd | Real estate | 2023 |
| Severn Valley Catering Limited | Hospitality | 1993 |
| Sewall Court Management Limited | Households | 1964 |
| Sexual Advice Association | Health & social care | 2003 |
| Seybra Star Limited | Real estate | 2025 |
| Seymour Business Services Limited | Information & communication | 2024 |
| SF Home Solution Company Limited | Professional & scientific | 2025 |
| SF Pressure Washing Ltd | Administrative & support | 2023 |
| SF Strategy Ltd | Information & communication | 2025 |
| SFA (UK) Limited | Professional & scientific | 2014 |
| SFI Solution Ltd | Information & communication | 2024 |
| SG 3131 Limited | Real estate | 2003 |
| SG 3232 Limited | Administrative & support | 1996 |
| SG Fleet Solutions UK Limited | Administrative & support | 2000 |
| SG Fleet UK Holdings Limited | Administrative & support | 2016 |
| SG Fleet UK Limited | Administrative & support | 2007 |
| SG2017 Limited | Real estate | 2017 |
| SG4040 Limited | Real estate | 2012 |
| SG5050 Limited | Extraterritorial | 2012 |
| Sgce Consult Ltd | Professional & scientific | 2024 |
| Sgml Limited | Wholesale & retail | 2020 |
| SGS Executive Limited | Transport & logistics | 2024 |
| SGS Hotels (Reading) Limited | Hospitality | 2016 |
| SGS Hotels (UK) Limited | Hospitality | 2012 |
| Sgta Property Ltd | Real estate | 2022 |
| SH & NB Properties Ltd | Real estate | 2019 |
| SHA Courier Ltd | Transport & logistics | 2020 |
| Shaded Housing Limited | Real estate | 2025 |
| Shadow Facilities Management Ltd | Administrative & support | 2023 |
| Shadow Properties Management Limited | Construction | 2026 |
| Shadow Support Ltd | Information & communication | 2011 |
| Shadowtech Ltd | Professional & scientific | 2016 |
| Shahallion Holdings Limited | Financial services | 2024 |
| Shahallion Investments Limited | Real estate | 2021 |
| Shahallion Limited | Real estate | 2010 |
| Shahallion Properties Ltd | Real estate | 2017 |
| Shahanaz C Limited | Wholesale & retail | 2021 |
| Shahed Yousaf Writer Limited | Arts & recreation | 2021 |
| Shahintrading Ltd | Financial services | 2026 |
| Shahnawaz Properties Limited | Real estate | 2023 |
| Shaicon Limited | Information & communication | 2012 |
| Shaimount Property Limited | Real estate | 2021 |
| Shairs Investment Limited | Real estate | 2020 |
| Shakespeare Drive Dental Centre Limited | Health & social care | 2011 |
| Shakib Khan Locums Limited | Other services | 2021 |
| Shakinsfood Ltd | Administrative & support | 2026 |
| Shameem Engineering Ltd | Construction | 2026 |
| Shameem Ltd | Real estate | 2019 |
| Shamrock Holdings LLP | | 2023 |
| Shan Fisher Education Ltd | Education | 2023 |
| Shandy Limited | Professional & scientific | 2003 |
| Shanley Electrical Services Ltd | Construction | 2018 |
| Shannon Edge Consulting Ltd | Professional & scientific | 2025 |
| Shareef & Co Limited | Professional & scientific | 2002 |
| Shareef Holdings Limited | Financial services | 2023 |
| Shareef Investments Limited | Real estate | 2001 |
| Shariff U Limited | Health & social care | 2021 |
| Shark Wave Ltd | Information & communication | 2024 |
| Sharkawy Vascular Clinic Ltd | Health & social care | 2026 |
| Sharkey Holdings Ltd | Financial services | 2023 |
| Sharma & Sharma Ltd | Real estate | 2022 |
| Sharma Living Ltd | Real estate | 2026 |
| Sharp Homes Ltd | Administrative & support | 2017 |
| Sharp Touch Maintenance Limited | Construction | 2020 |
| Sharpe Electrical Controls Limited | Wholesale & retail | 1989 |
| Shashank Testing Consultants Limited | Information & communication | 2012 |
| Shaun Shepherd Ltd | Construction | 2018 |
| Shaw Clothing Limited | Wholesale & retail | 2008 |
| Shaw Management Services Limited | Professional & scientific | 1997 |
| Shaw Marketing Consultants Limited | Professional & scientific | 2013 |
| Shayla BFC Limited | Arts & recreation | 2021 |
| Shazam Medical Services Ltd | Health & social care | 2015 |
| Shehitsdifferent Ltd | Education | 2025 |
| Sheldon Flooring Limited | Construction | 2006 |
| Sheldon Group Ltd | Financial services | 2024 |
| Sheldon Hire Limited | Administrative & support | 2011 |
| Sheldon Laundry Limited | Other services | 2017 |
| Sheldon One Property Developments Limited | Construction | 2009 |
| Sheldon Transport Compliance Ltd | Professional & scientific | 2026 |
| Shell & Core Limited | Other services | 2010 |
| SHEN10 Security Ltd | Professional & scientific | 2024 |
| Shepherd Commercial Limited | Real estate | 2014 |
| Sher S Properties Ltd | Hospitality | 2025 |
| Sherborne Street Developments Limited | Construction | 2015 |
| Shergill Group Ltd | Hospitality | 2018 |
| Sheridan Fitness Group Ltd | Education | 2026 |
| Sheridan Property Developments (Midlands) Ltd | Construction | 2016 |
| Sheridan Property Holdings Ltd | Real estate | 2025 |
| Shezanapharma Limited | Wholesale & retail | 2023 |
| Shifa Global Health Limited | Health & social care | 2025 |
| Shilton Burbage & Co Limited | Construction | 2016 |
| Shine Solutions Midlands Ltd | Administrative & support | 2024 |
| Shipston Gardens Management Company Limited | Households | 2019 |
| Shipweave AI Ltd | Wholesale & retail | 2022 |
| Shique Emporium Ltd | Wholesale & retail | 2024 |
| Shiraz Specialist Dental Services Ltd | Health & social care | 2022 |
| Shire Management Services Limited | Professional & scientific | 2021 |
| Shirley Barber Cutz Ltd | Other services | 2025 |
| Shirley Barber Ltd | Other services | 2025 |
| Shirley Business Services Limited | Wholesale & retail | 2001 |