| Emdopatestate Limited | Real estate | 2023 |
| Emeraid Limited | Real estate | 1996 |
| Emerald Estates Ltd | Construction | 2022 |
| Emerald Lantern Ltd | Real estate | 2025 |
| Emergency Site Services Ltd | Wholesale & retail | 2012 |
| Emerging Affinity Limited | Information & communication | 2020 |
| Eminat Transport Ltd | Transport & logistics | 2022 |
| Emines Bioscience Ltd | Wholesale & retail | 2011 |
| Emkay Supplies Ltd | Wholesale & retail | 2025 |
| Emma Hulse Limited | Professional & scientific | 2012 |
| Emma's Roses Ltd | Transport & logistics | 2024 |
| Emmett of Marlow Limited | Professional & scientific | 1986 |
| Emmr Enterprise Limited | Wholesale & retail | 2021 |
| Emmy Global Services Limited | Health & social care | 2018 |
| Emotions Sports Travel Limited | Administrative & support | 2013 |
| Emotive Cars Ltd | Wholesale & retail | 2022 |
| Empacy Ltd | Information & communication | 2023 |
| Empire Accounting Limited | Professional & scientific | 2009 |
| Empire Double Glazing Ltd | Construction | 2018 |
| Empire Estate Solutions Limited | Real estate | 2020 |
| Empire Storage Ltd | Transport & logistics | 2022 |
| Empirical Development Ltd | Construction | 2026 |
| Empiru Ltd | Construction | 2019 |
| Employ-Hub.Com Ltd | Administrative & support | 2025 |
| Employment Hub Ltd | Administrative & support | 2022 |
| Empower Stitch Ltd | Wholesale & retail | 2026 |
| Empowerment Studio Ltd. | Education | 2023 |
| Emranite Limited | Health & social care | 2009 |
| EMX O Ltd | Administrative & support | 2026 |
| Emysperfect Cleaners Ltd | Construction | 2020 |
| EN Medics Limited | Health & social care | 2022 |
| ENA Digital Services Ltd | Information & communication | 2016 |
| ENA Driving School Ltd | Education | 2024 |
| Enable Foundation UK Ltd | Administrative & support | 2022 |
| Enable Living Ltd | Extraterritorial | 2024 |
| Enchanted by Syma Limited | Other services | 2015 |
| Encouriers Ltd | Transport & logistics | 2025 |
| Endeavor Consulting Ltd | Professional & scientific | 2025 |
| Endodontic Ltd | Health & social care | 2023 |
| Endurance Health Ltd | Administrative & support | 2004 |
| Endurance Health Partners Ltd | Administrative & support | 2025 |
| Endurance Health Slough Ltd | Administrative & support | 2020 |
| Energealth Ltd | Wholesale & retail | 2025 |
| Energex Search Limited | Professional & scientific | 2025 |
| Energy Cleaning Services Ltd | Administrative & support | 2012 |
| Energy Innovation Solutions Limited | Information & communication | 2018 |
| Energy Reservist Ltd | Professional & scientific | 2025 |
| Energy Saviour Ltd | Professional & scientific | 2012 |
| Energy West Ltd | Construction | 2023 |
| Enest Solutions Limited | Information & communication | 2015 |
| ENG & Arabic Language Courses Ltd | Education | 2024 |
| Engage Estates Ltd | Real estate | 2026 |
| Engineered Estates Ltd | Real estate | 2023 |
| Engineering Support Solutions [UK] Limited | Administrative & support | 2012 |
| Englefield Green Limited | Agriculture & fishing | 2025 |
| Englobalpk Ltd | Education | 2024 |
| Enhance Management Services Ltd | Real estate | 2014 |
| Enhanced Biofuels and Technologies UK Limited | Information & communication | 2020 |
| Enhanced IT Limited | Information & communication | 2009 |
| ENI Design Limited | Construction | 2025 |
| Enigma Cleaning and Property Services Ltd | Administrative & support | 2019 |
| Enmar Productions Ltd | Information & communication | 2013 |
| Ennasors Ltd | Wholesale & retail | 2017 |
| Ennys Tasty Snacks Ltd | Hospitality | 2025 |
| Enomere Ltd. | Information & communication | 2015 |
| Enrich Accounts Ltd | Professional & scientific | 2020 |
| Enrich Trip Ltd | Real estate | 2016 |
| Enriched Care Support Services Limited | Health & social care | 2021 |
| Ensign Clinic Ltd | Health & social care | 2024 |
| Enterprise 9 Limited | Information & communication | 2015 |
| Enterprise Madina Ltd | Wholesale & retail | 2019 |
| Envex Energy Solutions Ltd | Construction | 2025 |
| Enviroclean Deep Cleaning Limited | Administrative & support | 2024 |
| Enviroclean Onestop Cleaning Ltd | Administrative & support | 2023 |
| Enviroclean Wheelie BIN Cleaning Ltd | Administrative & support | 2023 |
| Environ Heating Ltd | Construction | 2017 |
| Envirosafe Direct Ltd | Administrative & support | 2012 |
| Envision Tronix Limited | Information & communication | 2025 |
| Envo Shop Ltd | Other services | 2024 |
| Envosell Ltd | Wholesale & retail | 2025 |
| Enyo's Home Care Services Ltd | Health & social care | 2025 |
| Eonis.Aero Ltd | Professional & scientific | 2022 |
| Epage Limited | Information & communication | 2020 |
| Epedlar Limited | Wholesale & retail | 2025 |
| Epic Home Cinema Limited | Information & communication | 2014 |
| Epicurean Mobile Solutions Ltd | Wholesale & retail | 2018 |
| Epidote Properties Ltd | Real estate | 2025 |
| Epidote Services Limited | Administrative & support | 2025 |
| Epiventures Ltd | Wholesale & retail | 2025 |
| Epochs IT Limited | Information & communication | 2023 |
| Epos 247 Ltd | Information & communication | 2024 |
| EPP Consulting Ltd | Information & communication | 2022 |
| Eprimedata Ltd | Information & communication | 2023 |
| Epsilon TEN Ltd | Professional & scientific | 2021 |
| Epsom Holdings Limited | Real estate | 2023 |
| Epsom Projects Limited | Construction | 2011 |
| Equity Real Estate (Epsilon) Ltd | Real estate | 2014 |
| Equity Real Estate (Gamma) Ltd | Real estate | 2014 |
| ERB Trading Limited | Professional & scientific | 2020 |
| Ergon Investments International Limited | Professional & scientific | 1986 |