| Defenders Security Services Ltd | Administrative & support | 2024 |
| Defendo Eco Cleaning Services Ltd | Administrative & support | 2025 |
| Defense Network Systems Limited | Wholesale & retail | 2024 |
| Defensy UK Ltd | Administrative & support | 2025 |
| Defenzo Ltd | Administrative & support | 2026 |
| Defiant Frame Ltd | Information & communication | 2025 |
| Defnet Systems Limited | Wholesale & retail | 2024 |
| Dehal Construction London Ltd | Construction | 2024 |
| Dehra Consulting Ltd | Information & communication | 2016 |
| DEI Limited | Professional & scientific | 2021 |
| DEL Brickwork Ltd | Construction | 2018 |
| DEL Consultants Ltd | Education | 2013 |
| Del&Dee Ltd | Construction | 2014 |
| Delicacies by M Ltd | Manufacturing | 2021 |
| Delight Imports Ltd | Wholesale & retail | 2016 |
| Delikatesy Polskie Smaczek Limited | Wholesale & retail | 2010 |
| Delikatesy Smaczek (Luton) Limited | Wholesale & retail | 2014 |
| Delikatesy Smaczek Limited | Wholesale & retail | 2014 |
| Deliverush Limited | Wholesale & retail | 2016 |
| DELIVEXX24 Ltd | Transport & logistics | 2023 |
| Deliveyo Limited | Transport & logistics | 2023 |
| Delta Bedrooms & Kitchen Limited | Administrative & support | 2016 |
| Delta Catering Equipment Ltd | Wholesale & retail | 2020 |
| Delta Tower Cranes Limited | Construction | 2002 |
| Delux Chauffeur Drive Limited | Transport & logistics | 2010 |
| Deluxe Art Ltd | Arts & recreation | 2026 |
| Dema Technology Solutions Limited | Information & communication | 2018 |
| Deme UK Ltd | Wholesale & retail | 2021 |
| Demiqbill Works Ltd | Construction | 2025 |
| Demonte Corporations Ltd | Other services | 2025 |
| Demorgan Consultancy Limited | Professional & scientific | 2021 |
| Deneb Cybersecurity Consulting Limited | Information & communication | 2016 |
| Denham Village Superstore Ltd | Wholesale & retail | 2012 |
| Denholme Lodge RTM Company Limited | Households | 2016 |
| Denis Concrete Pump Service Ltd | Manufacturing | 2015 |
| Denmark Coachworks Body Repair Centre Limited | Wholesale & retail | 2020 |
| Dennison Property Ltd | Real estate | 2023 |
| Denta Nova Ltd | Manufacturing | 2025 |
| Dentaglitz International Ltd | Transport & logistics | 2023 |
| Dental Logistics Ltd | Health & social care | 2023 |
| Dentashift Ltd | Information & communication | 2026 |
| Denteam Ltd | Health & social care | 2023 |
| Dentello Consulting Ltd | Professional & scientific | 2025 |
| Dentello Holding Ltd | Financial services | 2025 |
| Dentello IP Ltd | Information & communication | 2025 |
| Dentello Ltd | Information & communication | 2025 |
| Dentkom Limited | Real estate | 2016 |
| Dentolegal Matters Limited | Health & social care | 2024 |
| Deohaus Properties Ltd | Real estate | 2025 |
| Deol Property Developments Limited | Real estate | 2024 |
| Deol Property Management and Investments Ltd | Real estate | 2015 |
| Deol Scaffolding Limited | Construction | 2023 |
| Deol Services Ltd | Transport & logistics | 2022 |
| Deol Super Construction Ltd | Construction | 2020 |
| Departing Ltd | Administrative & support | 2025 |
| Depotant Ltd | Wholesale & retail | 2024 |
| Deputy Emea Limited | Information & communication | 2017 |
| Dera Karahi Ltd | Hospitality | 2023 |
| Dera Properties Ltd | Real estate | 2025 |
| Dere Mangal Berk Ltd | Hospitality | 2025 |
| Dere Mangal Bucks Limited | Hospitality | 2025 |
| Dere Mangal Ltd | Hospitality | 2023 |
| Deritend Autos Ltd | Wholesale & retail | 2026 |
| Derma Enhanced Limited | Other services | 2020 |
| Deselby Care Ltd | Health & social care | 2025 |
| Desert Executive Ltd | Other services | 2025 |
| Desert Sign Supplies Ltd | Wholesale & retail | 2020 |
| Deserving Children Africa | Other services | 2010 |
| Deshhomes Limited | Real estate | 2021 |
| Desholé Limited | Professional & scientific | 2025 |
| Desi Foods Langley Ltd | Hospitality | 2025 |
| Design & Build Home Improvements Ltd | Construction | 2026 |
| Design & Contracting Services Limited | | 1967 |
| Design and Sourcing Knit Ltd | Wholesale & retail | 2019 |
| Design Renovation & Build Team Ltd | Construction | 2020 |
| Design Your Holidays by Eriola Ltd | Administrative & support | 2025 |
| Designed to Talk Limited | Information & communication | 2021 |
| Designs for Living Limited | Administrative & support | 2015 |
| Designtech Consulting Services Limited | Professional & scientific | 2018 |
| Desire Create Ltd | Information & communication | 2021 |
| Desktop Engineers Ltd | Professional & scientific | 2018 |
| Dest-Emma Limited | Health & social care | 2024 |
| Destinychild Limited | Health & social care | 2022 |
| Deus Group Ltd | Information & communication | 2022 |
| DEV Deol Properties & Development Ltd | Real estate | 2025 |
| DEV6 Limited | Construction | 2022 |
| Devbarn Ltd | Construction | 2024 |
| Devbiz Ltd | Information & communication | 2015 |
| Deveci Tech Ltd | Professional & scientific | 2020 |
| Developer BRO Ltd | Information & communication | 2025 |
| Development Initiative for Slough Housing Company Limited | Real estate | 1988 |
| Develvo Property Holdings Limited | Real estate | 2026 |
| Devgun Transport Ltd | Transport & logistics | 2025 |
| Device Hub Limited | Wholesale & retail | 2025 |
| Devinder Grewal Limited | Extraterritorial | 2025 |
| Devinder Singh Grewal Limited | Extraterritorial | 2025 |
| Devine Destiny Ltd | Health & social care | 2019 |
| Devlance Ltd | Information & communication | 2026 |
| Devonshire and SON Group Ltd | Construction | 2024 |
| Devops Engineering Services Limited | Information & communication | 2022 |