| Spellme Ltd | Information & communication | 2025 |
| Spelprop Limited | Real estate | 2024 |
| Spencer Rock Ltd | Households | 2025 |
| SPH Property Investments Limited | Real estate | 1999 |
| Sphiria Ltd | Wholesale & retail | 2022 |
| Sphita IT Limited | Information & communication | 2018 |
| Spice Aroma Ltd | Wholesale & retail | 2023 |
| Spice Factory Limited | Hospitality | 2022 |
| Spiceful Limited | Manufacturing | 2023 |
| Spicekart Limited | Wholesale & retail | 2025 |
| Spicy Chula Catering Ltd | Hospitality | 2024 |
| Spicy Tiffin Services Ltd | Hospitality | 2025 |
| Spilhaus & Co Ltd | Information & communication | 2022 |
| Spilt Wine Design Ltd | Professional & scientific | 2019 |
| Spin Trade Ltd | Wholesale & retail | 2020 |
| Spires Brickwork Ltd | Construction | 2018 |
| Spirit of Camden Ltd | Wholesale & retail | 2020 |
| Spitfire Enterprises Ltd | Real estate | 2021 |
| SPJ Tech Services Ltd | Health & social care | 2019 |
| Splash Industries Limited | Financial services | 2023 |
| Splash! City Limited | Information & communication | 2011 |
| Splash.Ai Ltd | Real estate | 2025 |
| Splendid Hub Ltd | Wholesale & retail | 2026 |
| Splendid Style Ltd | Wholesale & retail | 2024 |
| Spontanee Ltd | Professional & scientific | 2018 |
| Sportsempire Ltd | Wholesale & retail | 2025 |
| Spot on Southern Limited | Water & waste | 2007 |
| Spotless Cleans Services Ltd | Administrative & support | 2025 |
| Spow Strike Ltd | Wholesale & retail | 2025 |
| Spraytech Paint Services Holdings Limited | Financial services | 2024 |
| Spraytech Paint Services Ltd | Construction | 2005 |
| Springfield House Property Ltd | Hospitality | 2022 |
| Springtech Limited | Manufacturing | 1967 |
| Springvale Care Limited | Health & social care | 2018 |
| Sprog Group Limited | Arts & recreation | 2018 |
| Spromatch Limited | Wholesale & retail | 2025 |
| Sprout Solutions Ltd | Wholesale & retail | 2024 |
| SPS Builders Construction Ltd | Construction | 2024 |
| SPS Consulting Services Limited | Information & communication | 2006 |
| SPS Couriers & Haulage Ltd | Transport & logistics | 2018 |
| SPS Ptraining Limited | Professional & scientific | 2026 |
| Spsk Properties Ltd | Real estate | 2020 |
| Spynapse Limited | Information & communication | 2013 |
| Spyotech Ltd | Health & social care | 2020 |
| SQ Phone Sales Ltd | Wholesale & retail | 2025 |
| SQA Solutions Limited | Information & communication | 2007 |
| Sqlbox Ltd | Professional & scientific | 2018 |
| Squad Care Ltd | Health & social care | 2022 |
| Square BPM Ltd | Information & communication | 2024 |
| Square Developments Ltd | Construction | 2021 |
| Square Pizza Slough Ltd | Hospitality | 2017 |
| Squared Alpha Ltd | Information & communication | 2019 |
| Squeaky Ltd | Administrative & support | 2025 |
| Squeaky Trade Ltd | Wholesale & retail | 2020 |
| Squires Construction Limited | Construction | 2014 |
| SR Berks Limited | Wholesale & retail | 2018 |
| SR Heating & Plumbing Ltd | Construction | 2012 |
| SR Qa/Qc Consultancy Limited | Professional & scientific | 2024 |
| SR Soft Ltd | Information & communication | 2012 |
| SRA Consulting Limited | Professional & scientific | 2024 |
| Sran Dairies Ltd | Wholesale & retail | 2015 |
| Srav Investments Ltd | Real estate | 2018 |
| SRE Consultancy Ltd | Information & communication | 2021 |
| Sree Kali MAA Property Management Limited | Real estate | 2020 |
| Sree Kali MAA Solutions Limited | Information & communication | 2017 |
| Sreedha Estates Ltd | Construction | 2025 |
| SRG Global Services Group Ltd | Wholesale & retail | 2023 |
| SRG Portfolio Limited | Real estate | 2022 |
| SRI Computer Services Limited | Information & communication | 2024 |
| SRI Guruprem Sight Savers Limited | Health & social care | 2015 |
| SRI Hasi Technologies Limited | Information & communication | 2013 |
| SRI IT Solutions Ltd | Information & communication | 2020 |
| SRI Nivasam Ltd | Real estate | 2022 |
| SRI Purush Residence Ltd | Real estate | 2023 |
| SRI Radha Krishna IT Solutions Ltd | Information & communication | 2016 |
| SRI SAI Solutions Ltd | Information & communication | 2012 |
| SRI Siddhivinayaka Services Limited | Information & communication | 2021 |
| SRI UV Services Ltd | Professional & scientific | 2016 |
| Sriliya Properties Ltd | Real estate | 2025 |
| Sriven Investments Limited | Real estate | 2020 |
| Sriven Technology Limited | Information & communication | 2006 |
| Srivens Technologies Ltd | Information & communication | 2018 |
| Sriza Electronics Ltd | Wholesale & retail | 2021 |
| SRK Building Solutions Ltd | Construction | 2022 |
| SRL Dental Limited | Health & social care | 2024 |
| SRL Developments London Ltd | Real estate | 2024 |
| SRL Fashion Clothings Ltd | Manufacturing | 2018 |
| SRL Home Developments Ltd | Real estate | 2021 |
| SRM3 Tech Ltd | Information & communication | 2024 |
| SRN Inspire Ltd | Hospitality | 2024 |
| SRP World Ltd | Wholesale & retail | 2011 |
| Srql Tech Ltd | Wholesale & retail | 2025 |
| SRS Property Landlords Ltd | Real estate | 2023 |
| SRS Recovery Limited | Administrative & support | 2012 |
| Srsd Services Ltd | Construction | 2022 |
| SRV4 Limited | Professional & scientific | 2024 |
| SRZ Properties Limited | Real estate | 2017 |
| SS & PKB Ltd | Hospitality | 2020 |
| SS Care Services Ltd | Other services | 2025 |
| SS Digging & Building Development Limited | Construction | 2020 |