| S O Brickwork and Groundwork Limited | Construction | 2024 |
| S&B Sheppey Ltd | Wholesale & retail | 2026 |
| S&D Building ( Kent ) Ltd | Construction | 2021 |
| S&L Business Consulting Ltd | Professional & scientific | 2025 |
| S&M Kent Ltd | Hospitality | 2023 |
| S&S Civil Engineering Ltd | Construction | 2022 |
| S&S Prime Properties Ltd | Construction | 2025 |
| S. & A.Bowen Limited | Transport & logistics | 1940 |
| S.H.G.J Construction Ltd | Construction | 2018 |
| S.Marsh Carpentry Limited | Construction | 2016 |
| S.Page Flooring Ltd | Construction | 2009 |
| S.T & W Inspections Ltd | Professional & scientific | 2012 |
| S.T&W Laboratories Ltd | Professional & scientific | 2020 |
| Saber Surveying Solutions Limited | Professional & scientific | 2022 |
| Sacred Stone Events Ltd | Administrative & support | 2026 |
| Sads Trading Ltd | Wholesale & retail | 2023 |
| Safe Secure Vans Limited | Wholesale & retail | 2025 |
| Safehold Limited | Wholesale & retail | 2021 |
| Safeline GAS Solution UK Ltd | Construction | 2021 |
| Safety in Management International Limited | Professional & scientific | 2025 |
| Safety Support and Solutions Ltd | Professional & scientific | 2023 |
| Safeworkrails Ltd | Construction | 2018 |
| Safrismile Ltd. | Health & social care | 2010 |
| SAG Electrical Services Limited | Construction | 2022 |
| SAI Dhana Limited | Wholesale & retail | 2020 |
| Sakatat Limited | Extraterritorial | 2024 |
| SALAMANDER777 Ltd | Transport & logistics | 2016 |
| Salan Trans Limited | Transport & logistics | 2016 |
| Salisbury House Management Company (Canterbury) Limited | Households | 1989 |
| Salter FOX Legal Ltd | Professional & scientific | 2025 |
| Salter FOX Ltd | Other services | 2022 |
| Salters Law Bereavement Services Ltd | Professional & scientific | 2025 |
| Salvation Farm Limited | Health & social care | 2008 |
| SAM French Construction Ltd | Construction | 2026 |
| SAM Holland Events Ltd | Other services | 2020 |
| SAM Tatler Trading AS West Street Car Sales Ltd | Wholesale & retail | 2020 |
| SAM1TEC Ltd | Information & communication | 2023 |
| Samaj Services Limited | Information & communication | 2019 |
| Sammy Railservice UK Limited | Construction | 2016 |
| Sandeetech Solutions Limited | Professional & scientific | 2014 |
| Sandgate Pavilion Ltd | Real estate | 2021 |
| Sandhu Takeaway Limited | Hospitality | 2013 |
| Sanitising and Mould Solutions Ltd | Administrative & support | 2023 |
| Sanji Blue Limited | Hospitality | 2025 |
| Santa Maria Healthcare Limited | Health & social care | 2020 |
| Santao Ltd | Real estate | 2018 |
| Sanya International Ltd | Professional & scientific | 2022 |
| Sapphire Ace Limited | Health & social care | 2023 |
| Sapphire Construction and Renovation Ltd | Construction | 2022 |
| Sardel Limited | Administrative & support | 2006 |
| Sardel Properties Ltd | Other services | 2018 |
| Sarelina Store Ltd | Wholesale & retail | 2025 |
| Sarian & Fred Limited | Health & social care | 2023 |
| Sateda Homes Ltd | Real estate | 2021 |
| Sateda Limited | Public administration | 2013 |
| Saturn-Smart Limited | Wholesale & retail | 2018 |
| Savvtransport Ltd | Transport & logistics | 2019 |
| Sawdust Carpentry & Joinery Limited | Construction | 2014 |
| Saxby Safety Services Ltd | Extraterritorial | 2025 |
| Saxon HR Consultancy Ltd | Administrative & support | 2022 |
| Saxon Safety Solutions Ltd | Professional & scientific | 2024 |
| Sayers Cards and Collectables Ltd | Wholesale & retail | 2025 |
| SBC Holding Company 1 Limited | Real estate | 2020 |
| SBL Clothing Ltd | Wholesale & retail | 2025 |
| SBS Paraplanning Ltd | Administrative & support | 2022 |
| Scarlet Scott Dressage Limited | Arts & recreation | 2023 |
| Schipio Limited | Information & communication | 2016 |
| Scholartrip Educational Travels and Tour Limited | Education | 2025 |
| School Improvement Solutions Limited | Education | 2023 |
| School Lane Property Management Limited | Households | 2002 |
| Scientia Compliance Ltd | Financial services | 2008 |
| SCL Executive Travel Limited | Transport & logistics | 2020 |
| Scott James Watches Limited | Wholesale & retail | 2022 |
| Scott Jordan Entertainment Limited | Professional & scientific | 2007 |
| Scott's Hall Limited | Administrative & support | 2015 |
| Scottjames Limited | Financial services | 2022 |
| Screeding Solutions Ltd | Other services | 2017 |
| Scuderia Buildings Ltd | Real estate | 2025 |
| Scylla Limited | Hospitality | 2003 |
| SDA Site Investigation Ltd | Construction | 2017 |
| Sdam Limited | Wholesale & retail | 2023 |
| SDK Maintenance Services Limited | Administrative & support | 2025 |
| SDW Scaffolding Services Ltd | Construction | 2018 |
| Seabridge Enterprises Ltd | Hospitality | 2017 |
| Seamead Ltd | Hospitality | 2012 |
| Searle Security Ltd | Administrative & support | 2024 |
| Sears Communications Ltd | Information & communication | 2003 |
| Sears Worldwide Limited | Professional & scientific | 2012 |
| Seaside Sweets Ltd | Wholesale & retail | 2021 |
| Seasons Travel Limited | Administrative & support | 2003 |
| SEC Procurement Limited | Other services | 2023 |
| Secret Consultants Ltd | Construction | 2024 |
| Sedona Civils Holdings Ltd | Financial services | 2025 |
| Sedona Civils Ltd | Construction | 2014 |
| Seed Rise Community CIC | Education | 2026 |
| Seed Rise Education Ltd | Education | 2024 |
| Seed Rise Impact Limited | Administrative & support | 2026 |
| Sejaura UK Limited | Wholesale & retail | 2022 |
| Sekazab Limited | Hospitality | 2024 |
| Selectron (U K) Limited | Wholesale & retail | 1988 |