| Shropshire Sand Blasting Limited | Construction | 2022 |
| Shropshire Smart Repairs Limited | Wholesale & retail | 2014 |
| Shropshire Stainless & Aluminium Ltd | Wholesale & retail | 2006 |
| Shropshire Stainless Fabrications Limited | Manufacturing | 1995 |
| Shropshire Stove and Chimney Centre Limited | Manufacturing | 2000 |
| Shropshire Stove Fitting Ltd | Construction | 2006 |
| Shropshire Takeaways Limited | Hospitality | 2025 |
| Shropshire Technology Ltd | Other services | 2016 |
| Shropshire Thriving Communities Alliance CIC | Administrative & support | 2025 |
| Shropshire Tours Limited | Administrative & support | 2012 |
| Shropshire Towns and Rural Housing Limited | Real estate | 2012 |
| Shropshire Traders Ltd | Wholesale & retail | 2024 |
| Shropshire Trading Limited | Wholesale & retail | 2014 |
| Shropshire Training Limited | Education | 2009 |
| Shropshire Tree Services Limited | Agriculture & fishing | 2004 |
| Shropshire Upper Limb Surgery Limited | Health & social care | 2012 |
| Shropshire Vending Services Ltd | Wholesale & retail | 2006 |
| Shropshire Water Forum CIC | Professional & scientific | 2025 |
| Shropshire Web Team Limited | Information & communication | 2020 |
| Shropshire Wildlife Trading Company Limited | Wholesale & retail | 1989 |
| Shropshire Wildlife Trust | Arts & recreation | 1962 |
| Shropshire Women in Business Ltd | Education | 2024 |
| Shropshire Workwear Solutions Limited | Wholesale & retail | 2015 |
| Shropshire Youth Support Trust | Administrative & support | 2015 |
| Shropshirenet Limited | Information & communication | 2022 |
| Shuker Building & Development Limited | Construction | 2021 |
| Shuker Holdings Ltd | Real estate | 2022 |
| Shuker Lettings Ltd | Real estate | 2024 |
| Shyre Bikes Limited | Manufacturing | 2024 |
| Sidmedz Ltd | Health & social care | 2026 |
| Sidoli Bros. Limited | Real estate | 1958 |
| Sidwell Consulting and Analytical Services Limited | Professional & scientific | 2009 |
| Sightique Optic Supplies UK Limited | Manufacturing | 2020 |
| Sign and Poster Limited | Manufacturing | 2007 |
| Sign and Print Shropshire Ltd | Manufacturing | 2016 |
| Signal Consulting Ltd | Professional & scientific | 2017 |
| Signature Event Planners Ltd | Hospitality | 2025 |
| Signature Home Developments Ltd | Construction | 2023 |
| Signature Publishing Limited | Information & communication | 2005 |
| Silentbrook Ltd | Arts & recreation | 2013 |
| Silesian Estates Limited | Real estate | 2024 |
| Silk Flower Design Ltd | Wholesale & retail | 2019 |
| Silk Surveyors Limited | Professional & scientific | 2024 |
| Silken Court Management Company (NO. 1) Limited | Households | 2001 |
| Silken Court Management Company (NO. 2) Limited | Households | 2001 |
| Silva Gardens Management Limited | Real estate | 2022 |
| Silvatherm Energy Ltd | Manufacturing | 2013 |
| Silver Homes and Renovations Ltd | Construction | 2024 |
| Silver Horse Property Ltd | Real estate | 2023 |
| Silver Rise (South Petherton) Ltd | Construction | 2025 |
| Silverbirch Holdings Limited | Financial services | 2019 |
| Silverdale (NO. 2) Residents Association Limited | Professional & scientific | 2003 |
| Silverton Solutions Ltd | Information & communication | 2019 |
| Silvervale Park Residents Estate Management Company Limited | Households | 2018 |
| Sim's Trims Hoof Care Ltd | Agriculture & fishing | 2020 |
| Simay & Simar Limited | Hospitality | 2025 |
| Simcliff Investments Limited | Financial services | 1970 |
| Simcox Ltd | Agriculture & fishing | 2018 |
| Simon Croft Plumbing and Heating Limited | Construction | 2014 |
| Simpli Technical Recruitment Limited | Administrative & support | 2018 |
| Simply Elegant Cleaning Services Limited | Administrative & support | 2024 |
| Simply Green Shropshire Limited | Administrative & support | 2024 |
| Simply Secure (UK) Ltd | Construction | 2014 |
| Simpson & Oakley Limited | Hospitality | 2023 |
| Simpson Square (RTM Company) Limited | Households | 2012 |
| Singh Kaur Trading Ltd | Hospitality | 2022 |
| Sinophenia Limited | Information & communication | 2017 |
| Sipa Homes Ltd | Real estate | 2022 |
| Sira Aviation Limited | Professional & scientific | 2020 |
| Siro Property Lettings Ltd | Real estate | 2025 |
| Siruss Ltd | Professional & scientific | 2013 |
| Siya Baltic Ltd | Wholesale & retail | 2025 |
| SJH Group Shropshire Limited | Construction | 2014 |
| SJH Home Group Ltd | Construction | 2023 |
| SJL Cars Limited | Wholesale & retail | 2006 |
| SJL1 Limited | Construction | 2023 |
| SJL2 Limited | Construction | 2023 |
| Skegby Lane (Mansfield) Management Limited | Households | 2004 |
| Skilltime Training Academy Limited | Education | 2017 |
| Skin Deep Clinic (Shrewsbury) Limited | Health & social care | 2017 |
| Skin Sentials Shrewsbury Limited | Other services | 2023 |
| Sknte Ltd | Wholesale & retail | 2024 |
| Sky Arts International Limited | Wholesale & retail | 2015 |
| Sky Court (Worcester) Management Limited | Households | 2007 |
| Sky Top Building Ltd | Construction | 2023 |
| Skylake Energy Limited | Manufacturing | 2024 |
| Skylake Limited | Manufacturing | 2020 |
| Skylake Medical Limited | Manufacturing | 2016 |
| Skylarks Outdoors Ltd | Health & social care | 2025 |
| Skyona Design Limited | Professional & scientific | 2005 |
| SL Auto Service & Tyre Ltd | Wholesale & retail | 2019 |
| Slater Transport Limited | Transport & logistics | 2007 |
| Sleap Sawmills Limited | | 1985 |
| Sleep Dragon Limited | Information & communication | 2005 |
| Slimfellows Ltd | Other services | 2017 |
| Sloane Terrace Mansions Management Limited | Real estate | 1989 |
| Slogunz. Limited | Manufacturing | 2020 |
| Slrc Trading Limited | Health & social care | 2006 |
| SLS Forensics Limited | Professional & scientific | 2008 |
| SLT Management Ltd | Construction | 2025 |