| Sandford Court Freehold Company Limited | Households | 1996 |
| Sandford Court Management Company (Church Stretton) Limited | Households | 1988 |
| Sandford Gardens Management Limited | Households | 2006 |
| Sandon Court (Fordhouses) Management Limited | Households | 2004 |
| Sandon Court,Goodmayes Lane.(Management)Limited | Households | 1970 |
| Sandringham Court (Shrewsbury) Limited | Real estate | 1990 |
| Sansaw Dairies Limited | Agriculture & fishing | 2006 |
| Sansaw Estates Ltd NO 1 Limited | Professional & scientific | 2018 |
| Sansaw Estates Ltd NO 2 Limited | Professional & scientific | 2018 |
| Sansaw Ltd | Real estate | 1983 |
| Sansaw Properties Limited | Real estate | 2023 |
| Sansaw Utilities Limited | Water & waste | 2023 |
| Santora Technology UK Limited | Extraterritorial | 2008 |
| Sapphire Atlantic Limited | Transport & logistics | 2021 |
| Sapphire Continental Limited | Transport & logistics | 2020 |
| Sara England Ltd | Construction | 2018 |
| Sarah Belcher Events Ltd | Professional & scientific | 2016 |
| Sarah Bentley Consultancy Limited | Education | 2010 |
| Sarah J Davies Limited | Professional & scientific | 2025 |
| Sarah Naylor Financial Services Ltd | Financial services | 2020 |
| Sarah Reynolds Limited | Professional & scientific | 2023 |
| Sarah Stone Consulting Limited | Professional & scientific | 2020 |
| Saralan Glass Design Limited | Construction | 2010 |
| Sarn Oak Meadow Management Company Limited | Households | 2022 |
| Satchels Court Management Company Limited | Real estate | 2008 |
| Saturnine Ltd | Wholesale & retail | 2022 |
| Satveer Nijjar Limited | Health & social care | 2022 |
| Saverite (Harlescott) Limited | Extraterritorial | 1980 |
| Saverite Limited | Extraterritorial | 1968 |
| Sawj Consulting Limited | Information & communication | 2007 |
| Saxon Fields (Management Company) Limited | Households | 2008 |
| SB Cleaning and Ironing Services Ltd | Administrative & support | 2022 |
| SB Consultancy (Shrewsbury) Ltd | Professional & scientific | 2017 |
| SB Property (Nantwich) Ltd | Real estate | 2020 |
| SB Surgery Ltd. | Health & social care | 2020 |
| SBC Holdings Limited | Professional & scientific | 2008 |
| SBC Training Limited | Education | 2011 |
| Sbdo Mechanical Ltd | Wholesale & retail | 2025 |
| SBS Flat Roofing Ltd | Construction | 2026 |
| Sbyt Group Limited | Hospitality | 2020 |
| Sbyt Investments Limited | Professional & scientific | 2022 |
| Scale and Scope Ltd | Professional & scientific | 2018 |
| Scan 360 Surveys Limited | Professional & scientific | 2024 |
| Scaredy KAT Productions Limited | Administrative & support | 1993 |
| SCH Holdings Limited | Administrative & support | 2014 |
| Schofield Business Services Limited | Professional & scientific | 2007 |
| Scholars Heath (Bilston Lane) Management Limited | Households | 2005 |
| School Shop Direct Limited | Wholesale & retail | 2015 |
| SCHOOLS4HEALTH UK Ltd | Health & social care | 2017 |
| Scissor Sisters Salon Ltd | Other services | 2026 |
| Sclc Limited | Public administration | 2020 |
| Scorpion Motors Limited | Wholesale & retail | 2016 |
| Scott & Newman Contracts Limited | Wholesale & retail | 2013 |
| Scott & Newman Holdings Limited | Professional & scientific | 2011 |
| Scott & Newman Limited | Wholesale & retail | 1973 |
| SCS Driveways and Paving Ltd | Construction | 2020 |
| SCT Legal Services Limited | Administrative & support | 2011 |
| SCW Health Ltd | Health & social care | 2025 |
| SDE Pressings Limited | Extraterritorial | 1990 |
| SDE Technology Ltd | Manufacturing | 2020 |
| SDP Plymouth Limited | Real estate | 2022 |
| SE Dairy Ltd | Wholesale & retail | 2026 |
| SE7EN International Ltd | Professional & scientific | 2024 |
| Sea Change Psychotherapy Limited | Health & social care | 2016 |
| Sea Feather Marine Ltd | Wholesale & retail | 2023 |
| Seabrook Court Management Company Limited | Households | 2003 |
| Seabrook Mews Management Company Limited | Households | 2005 |
| Sealing Technology Limited | Extraterritorial | 2008 |
| Sean Caddick Architectural Limited | Professional & scientific | 2014 |
| Sean Corka Photography Ltd | Professional & scientific | 2019 |
| Sean Griffiths Electrical Contractors Ltd | Construction | 2022 |
| Search and Submit Limited | Information & communication | 2003 |
| Searle Group Ltd | Administrative & support | 2015 |
| Second Gunwharf Gate Management Company Limited | Households | 1986 |
| Secret Snowdonia Limited | Hospitality | 2019 |
| Section TEN Ltd | Wholesale & retail | 2022 |
| Secure Comfort Ltd | Wholesale & retail | 2021 |
| Securebytes Solutions Ltd | Information & communication | 2024 |
| Security Investments (Industrial) Limited | Other services | 1946 |
| Seebi Medical Practice Limited | Health & social care | 2023 |
| Seed Data Solutions Limited | Information & communication | 2021 |
| Seedley Limited | Real estate | 2024 |
| Seeds of Change Enterprise Ltd | Professional & scientific | 2021 |
| Seeds to Thrive Ltd | Hospitality | 2022 |
| Sehs Global Limited | Construction | 2013 |
| Seifton Storage Solutions Limited | Other services | 2018 |
| Seisq Consulting Ltd | Professional & scientific | 2015 |
| SEJ Money Limited | Professional & scientific | 2021 |
| Select a Skip Limited | Extraterritorial | 2005 |
| Select a Skip UK Limited | Administrative & support | 1997 |
| Select Holdings (UK) Limited | Financial services | 2005 |
| Select Livestock Limited | Extraterritorial | 2015 |
| Select Storage LLP | | 2009 |
| Self Help Africa (UK) | Extraterritorial | 1988 |
| Sell My Motorhome and Camper Limited | Wholesale & retail | 2022 |
| Senescura Limited | Construction | 2021 |
| SENSPV1 Limited | Construction | 2026 |
| SENSPV2 Limited | Construction | 2026 |
| SENSPV3 Limited | Construction | 2026 |
| SENSPV4 Limited | Construction | 2026 |