| DR Jessica Crumpton Limited | Health & social care | 2023 |
| DR KAY Medical Practice Limited | Health & social care | 2025 |
| DR MD Aesthetics Limited | Health & social care | 2024 |
| DR Michael Bond Limited | Health & social care | 2016 |
| DR Rita Marinho Limited | Health & social care | 2025 |
| DR SF HO Medical Practice Ltd | Health & social care | 2024 |
| DR Suzanne M Jones Ltd | Education | 2019 |
| DR Tasha Malcolm Ltd | Professional & scientific | 2022 |
| DR Thomas Ingram Limited | Health & social care | 2016 |
| DR Victoria Watton Clinical Psychologist Ltd | Health & social care | 2024 |
| DR. Eco Contractors Ltd | Construction | 2018 |
| DR. James Russell Limited | Health & social care | 2010 |
| Dr.E. Contractors Ltd | Construction | 2014 |
| Dragon Engineering Limited | Administrative & support | 2016 |
| Dragon Haulage Ltd | Transport & logistics | 2025 |
| Drakes Mere Management Company Ltd | Households | 2005 |
| Dralian Ltd | Wholesale & retail | 2020 |
| Drama Chameleon | Arts & recreation | 2019 |
| Drapers Fields Management Company Limited | Households | 1997 |
| Drapers Hall SY1 Ltd | Hospitality | 2021 |
| Drayton Mill Limited | Households | 2002 |
| Dream Cloud Consultancy Ltd | Information & communication | 2019 |
| Dream Leotards Ltd | Wholesale & retail | 2026 |
| Dream Sugar-Free Foods Limited | Wholesale & retail | 2024 |
| Dreco Resource Management Limited | Administrative & support | 2017 |
| Drefach Property Management Ltd | Households | 2026 |
| Drew Flavell Limited | Professional & scientific | 2018 |
| Drift Castle Estates Ltd | Real estate | 2025 |
| Drilling Products Limited | Construction | 2009 |
| Driveon Vehicle Rental Limited | Administrative & support | 2025 |
| Driver Line Limited | Wholesale & retail | 2003 |
| DRM Aggregate Solutions Ltd | Water & waste | 2019 |
| DRO Investments Ltd | Financial services | 2020 |
| Drone Cleaning System Ltd | Administrative & support | 2024 |
| Dropsocks Ltd | Wholesale & retail | 2025 |
| Drupac Limited | Information & communication | 2014 |
| DSD Plumbing and Heating Limited | Construction | 2012 |
| DSP Controls and Automation Ltd | Manufacturing | 2017 |
| DT Enterprises (Logistics) Limited | Transport & logistics | 2005 |
| DT Sports Consultancy Limited | Other services | 2014 |
| DT Trading Shrewsbury Ltd | Wholesale & retail | 2023 |
| DT2 Properties Ltd | Real estate | 2023 |
| Dtlsynergy Ltd | Hospitality | 2024 |
| Dtonic UK Limited | Information & communication | 2026 |
| Ducks Hill Properties Ltd | Real estate | 2020 |
| Dudas Smith Consulting Limited | Wholesale & retail | 2022 |
| Duffy's Diner Limited | Manufacturing | 2018 |
| Dukescroft Limited | Real estate | 2015 |
| Dulings Meadow Management Company Limited | Households | 2005 |
| Dulson Training Limited | Other services | 2013 |
| Duncan Campbell Ltd | Manufacturing | 2008 |
| Duncan M Wheeler Shrewsbury Limited | Administrative & support | 2021 |
| Dunham Road Management Company Limited | Real estate | 2020 |
| Dunny Leisure Limited | Administrative & support | 2017 |
| Dunsil Place Estate Management Company Limited | Real estate | 2019 |
| Duport Quays (Dudley Port) Management Limited | Households | 2005 |
| Duru Studios Limited | Professional & scientific | 2025 |
| Duru Technology Ltd | Information & communication | 2025 |
| Dusty Boys Ltd | Wholesale & retail | 2020 |
| DVA Transport Ltd | Transport & logistics | 2019 |
| DVC Group Holdings Limited | Financial services | 2023 |
| DVC Group Limited | Professional & scientific | 2016 |
| Dvdmegastore Ltd | Wholesale & retail | 2022 |
| DWH Digital Limited | Information & communication | 2019 |
| DWK Law Limited | Professional & scientific | 2025 |
| DWM Psychology Services Limited | Education | 2025 |
| DY Digital Limited | Professional & scientific | 2022 |
| DY USA LLP | | 2022 |
| Dyas Brothers Limited | Real estate | 1934 |
| Dyke Yaxley (USA) Limited | Administrative & support | 2015 |
| Dyke Yaxley Limited | Professional & scientific | 2003 |
| Dylan Civils Ltd | Construction | 2022 |
| Dynacom IT Support Limited | Information & communication | 2003 |
| Dynalogic Consulting Limited | Information & communication | 2016 |
| Dynalogic Ltd | Professional & scientific | 2000 |
| E & M Shrewsbury Holdings Ltd | Financial services | 2025 |
| E 4 Environment Limited | Professional & scientific | 1999 |
| E B Thomas Limited | Financial services | 2021 |
| E Broomfield Limited | Professional & scientific | 2019 |
| E G Davies & SON Ltd | Construction | 2010 |
| E K J Contracts Limited | Construction | 2019 |
| E M E Developments & Holdings Ltd | Construction | 2018 |
| E Vape Shop Ltd | Wholesale & retail | 2023 |
| E. Chidlow and Company Limited | Wholesale & retail | 1948 |
| E. H. Owen Funeral Directors Ltd | Other services | 2016 |
| E.A. Downes & Sons Limited | Wholesale & retail | 2000 |
| E.G. Rees Limited | Professional & scientific | 2011 |
| E.R. Leisure (Holdings) Limited | Real estate | 2016 |
| E.R. Leisure Limited | Hospitality | 1996 |
| EAC Locum Ltd | Professional & scientific | 2019 |
| Eagle EYE Radiology Ltd | Health & social care | 2024 |
| Eagle House Properties Ltd | Real estate | 2003 |
| Earley Accommodation Limited | Hospitality | 2018 |
| Earls Meadow (WEM) Management Company Limited | Households | 2008 |
| Earlstone Ltd | Construction | 2000 |
| Earlyweb Holdings Limited | Real estate | 2025 |
| Earlyweb Limited | Extraterritorial | 2025 |
| Earlyworld Holdings Limited | Education | 2025 |
| Earlyworld Limited | Education | 1992 |
| East Village (South) Residents Company Limited | Households | 2004 |