| Sofa Sanctuary (Yorkshire) Limited | Wholesale & retail | 2024 |
| Sofa Warehouse (Denholme) Limited | Wholesale & retail | 2025 |
| Sofa Warehouse (Riddlesden) Limited | Wholesale & retail | 2025 |
| Soft Dynamic Ltd | Wholesale & retail | 2021 |
| Soil and Structures Limited | Construction | 2019 |
| SOL Davy Ltd | Wholesale & retail | 2025 |
| Solace Q Care Ltd | Health & social care | 2025 |
| Solar Capture Ltd | Construction | 2025 |
| Solbraze Limited | Manufacturing | 2013 |
| Solo Kitchens Limited | Wholesale & retail | 2011 |
| Solutionz (Bradford) Ltd | Wholesale & retail | 2020 |
| SOQ Supplements Limited | Wholesale & retail | 2023 |
| Sorelle Hair and Beauty Limited | Other services | 2019 |
| SOS Concert Productions Limited | Arts & recreation | 2010 |
| Soul and Glow Ltd | Other services | 2025 |
| Sound Shirts Ltd | Wholesale & retail | 2023 |
| Sovereign Assured Partners Limited | Financial services | 2016 |
| Sovereign Health and Insurance Services Limited | Financial services | 2010 |
| Sovereign Health Care | Financial services | 1905 |
| Sovereign Solicitors Limited | Professional & scientific | 2004 |
| SP Sports Massage Therapy Limited | Health & social care | 2024 |
| SP125 Limited | Wholesale & retail | 2004 |
| Space Kraft Limited | Wholesale & retail | 1992 |
| Specialised Car Covers Limited | Professional & scientific | 2010 |
| Specialised Covers Limited | Manufacturing | 1988 |
| Specialist Access Lifting and Testing Services Ltd | Construction | 2026 |
| Specialist Security Worldwide Limited | Other services | 2015 |
| Speculate Properties UK Ltd | Real estate | 2021 |
| Spices Grill BFD Ltd | Hospitality | 2026 |
| Spills & Splash Ltd | Manufacturing | 2018 |
| Spiral Food Solutions Limited | Manufacturing | 2023 |
| Split Design Ltd | Professional & scientific | 2011 |
| Sporting Life Stories Limited | Arts & recreation | 2017 |
| Sporting Support Services Limited | Administrative & support | 2014 |
| Sportsshoes.Com Group Limited | Financial services | 2021 |
| Sporttec Limited | Arts & recreation | 2013 |
| Spowage Mills Property Ltd | Real estate | 2023 |
| Spray Engineering Limited | Wholesale & retail | 2002 |
| Spring Software Consultancy Limited | Real estate | 2015 |
| Springwell House Management Company Limited | Households | 2004 |
| Sprnkls Ltd | Hospitality | 2024 |
| Spud HUT Ltd | Hospitality | 2022 |
| Sqft Construction Limited | Construction | 2025 |
| Squaredoff Limited | Professional & scientific | 2012 |
| Squirrel Reclamation Limited | Wholesale & retail | 2022 |
| SS Active Community Interest Company | Arts & recreation | 2023 |
| SS Chinese Ltd | Hospitality | 2024 |
| Ssgr Properties Limited | Real estate | 2022 |
| ST Peters Gate Residents Company Limited | Households | 2025 |
| Stainforth Construction LLP | | 2010 |
| Stainless Steel Pumps and Valves Ltd | Manufacturing | 2006 |
| Stamp App Ltd | Information & communication | 2024 |
| Standinwave Limited | Information & communication | 2010 |
| Stather Asbestos Services Limited | Construction | 2018 |
| Stather Asbestos Surveys Limited | Professional & scientific | 2025 |
| Station Marketing Agency Ltd | Professional & scientific | 2023 |
| Station Recruitment Ltd | Administrative & support | 2023 |
| Stay Safe Plumbing & GAS Limited | Construction | 2020 |
| Staybright Solutions Limited | Households | 2015 |
| Stealth IT Solutions Ltd | Wholesale & retail | 2016 |
| Steel Pressings Ltd | Manufacturing | 2002 |
| Stephen Pinnington (Nantwich) Limited | Professional & scientific | 2009 |
| Stern Industries Ltd | Manufacturing | 2013 |
| Steve Dolan Consulting Ltd | Professional & scientific | 2023 |
| Steven HOY Ltd | Information & communication | 2025 |
| Stevenson & Parker Dormant Limited | Professional & scientific | 1991 |
| Stone-Set Driveways and Patios Ltd | Administrative & support | 2025 |
| Stoneform Surfaces Ltd | Construction | 2026 |
| Stonehouse Commercial Properties Ltd | Real estate | 2023 |
| Stonelea 2004 Management Company Limited | Households | 2003 |
| Stonepeak Real Estate Ltd | Real estate | 2025 |
| Storage and Removals Group Limited | Transport & logistics | 2024 |
| Storenova Ltd | Information & communication | 2025 |
| Storrs MC Ltd. | Construction | 2018 |
| Stott Secretarial Services Limited | Professional & scientific | 2013 |
| Strange Labs Computers Ltd | Information & communication | 2022 |
| Street Space Community CIC | Professional & scientific | 2019 |
| Striding Edge (Payments) Ltd | Professional & scientific | 2016 |
| STS Supplies Ltd | Wholesale & retail | 2022 |
| STT Biomass Limited | Other services | 2022 |
| STT Renewables Limited | Other services | 2021 |
| Studio 92 Consultancy Ltd | Manufacturing | 2025 |
| SUE Smit Ltd | Professional & scientific | 2018 |
| Sugarush (Stockport) Limited | Wholesale & retail | 2024 |
| Sulaimaan Industries Ltd | Real estate | 2014 |
| Summat Creative Community Interest Company | Education | 2022 |
| Sunfold View Property Limited | Real estate | 2026 |
| Superview Window Cleaning Services Limited | Administrative & support | 2023 |
| Supreme Joinery Limited | Manufacturing | 2017 |
| Surface Clinic Limited | Health & social care | 2013 |
| Surpass Assessment Limited | Extraterritorial | 2022 |
| Sustain Psychology Limited | Education | 2024 |
| Sustainable Wellbeing Solutions C.I.C. | Education | 2015 |
| Suvalis Ltd | Administrative & support | 2025 |
| Svalbard Ltd. | Arts & recreation | 2021 |
| SVF Fisheries Ltd | Hospitality | 2024 |
| SW and NJW Limited | Professional & scientific | 2016 |
| Sweet Tooth (BFD) Limited | Hospitality | 2024 |
| Swift Property Management & Consultancy Limited | Administrative & support | 2014 |
| Swiftlink Tech Ltd | Wholesale & retail | 2022 |