| S a M Electrical Contractors Ltd | Manufacturing | 2024 |
| S Boddington Ltd | Other services | 2014 |
| S J Pharma Ltd | Health & social care | 2015 |
| S Mansoor Psychiatry Services Ltd | Health & social care | 2022 |
| S R Nicholson Properties Limited | Information & communication | 2023 |
| S.A.Engineering (UK) Limited | Real estate | 2012 |
| S.G.Ellis Group Limited | Administrative & support | 2022 |
| S0LUTI0NS OFR Ltd | Professional & scientific | 2019 |
| SA Business Enterprises Ltd | Wholesale & retail | 2011 |
| SAB Packaging Limited | Administrative & support | 2026 |
| Sadarfragrances Ltd | Wholesale & retail | 2025 |
| Safe Energy Solutions UK Ltd | Construction | 2025 |
| Safepage Property Limited | Real estate | 2025 |
| Sahota Logistics Limited | Transport & logistics | 2024 |
| Sailvista Ltd | Manufacturing | 2023 |
| Saint-Marc Consulting Ltd | Professional & scientific | 2023 |
| Sajida Manzoor Dietetics Ltd | Public administration | 2022 |
| Salad Fayre (at Wibsey) Limited | Hospitality | 2010 |
| Salad Fayre Properties Limited | Real estate | 2004 |
| Salt and West Limited | Wholesale & retail | 2022 |
| Saltaire Asset Management Limited | Real estate | 2006 |
| Saltaire Bridal Limited | Wholesale & retail | 2021 |
| Saltaire Clothing Limited | Wholesale & retail | 2025 |
| Saltaire Community Festival | Arts & recreation | 2004 |
| Saltaire Community Festival Trading Company Limited | Arts & recreation | 2025 |
| Saltaire Fermentary Limited | Manufacturing | 2025 |
| Saltaire Kitchens Ltd | Wholesale & retail | 2025 |
| Saltaire Mini Market Ltd | Wholesale & retail | 2022 |
| Saltaire Opticians Limited | Wholesale & retail | 2023 |
| Saltaire Partnerships CIC | Education | 2026 |
| Saltaire Properties Limited | Real estate | 2020 |
| Saltaire Self Storage Limited | Other services | 2026 |
| Saltaire Soap Ltd | Manufacturing | 2017 |
| Saltaire Wines Limited | Wholesale & retail | 2010 |
| Salthair Limited | Other services | 2017 |
| Salthaus Limited | Administrative & support | 2015 |
| Salts Fire & Security Holdings Limited | Financial services | 2025 |
| Salts Fire & Security Ltd | Construction | 2014 |
| Salts Mill Crafts Limited | Wholesale & retail | 2023 |
| SAM Care Agency Limited | Health & social care | 2014 |
| Saman Worldwide Tourism Ltd | Administrative & support | 2025 |
| Samantha Parker Dormant Limited | Professional & scientific | 2003 |
| Sami & Ehsan Properties Limited | Real estate | 2025 |
| Sami Yorkshire Properties Limited | Real estate | 2019 |
| Sandal Park (Baildon) Limited | Real estate | 2004 |
| Saqib Ayub Ltd | Information & communication | 2021 |
| Sarah Hawkins Consulting Ltd | Professional & scientific | 2024 |
| Sardar & Sons Tyres Wholesale Ltd | Wholesale & retail | 2025 |
| Sarema (UK) Limited | Other services | 1996 |
| Sarwan & Amber Ltd | Real estate | 2025 |
| Sarwar Capital Limited | Real estate | 2024 |
| SAS Management Ltd | Health & social care | 2013 |
| Sassy Brides Ltd | Wholesale & retail | 2024 |
| Sayad & Shah Limited | Health & social care | 2023 |
| Sayun Consulting Limited | Information & communication | 2016 |
| SB E.S.S. Ltd | Construction | 2018 |
| Scan-Thors (U.K.) Limited | Wholesale & retail | 1990 |
| Scandinavian House Developments Limited | Construction | 2014 |
| Scandinavian House Holdings Limited | Professional & scientific | 2014 |
| Scandinavian House Limited | Wholesale & retail | 2000 |
| Scandinavian House Logistics Ltd | Wholesale & retail | 2023 |
| Scatterbox Limited | Manufacturing | 2013 |
| Scenthound Graphic Design Limited | Professional & scientific | 2018 |
| School BUS Services Ltd | Transport & logistics | 2012 |
| Scruffs and Tufts Limited | Other services | 2015 |
| Scuffs 'N' Scrapes (Yorkshire) Limited | Wholesale & retail | 2025 |
| Sculptaire Aesthetics Ltd | Health & social care | 2026 |
| SD Pharmacare Limited | Health & social care | 2026 |
| SDC Site Engineering Ltd | Professional & scientific | 2024 |
| SDS Solutions Limited | Health & social care | 2013 |
| Seabee Freight Services Limited | Administrative & support | 2010 |
| Seba Developments Limited | Manufacturing | 1979 |
| Seedlings Speech and Language Therapy CIC | Health & social care | 2019 |
| Select 1 Contracting Limited | Construction | 2015 |
| Select 1 Security & Electrical Limited | Manufacturing | 2009 |
| Select Driveways Limited | Construction | 2012 |
| Self-Care Sentiments Ltd | Wholesale & retail | 2025 |
| Sellise Ltd | Manufacturing | 2017 |
| Sendex Logistics Limited | Transport & logistics | 2022 |
| Sensate Therapy Ltd | Health & social care | 2021 |
| Sensational Hair and Beauty Limited | Education | 2013 |
| Sensory Cave Limited | Manufacturing | 2021 |
| Sentinel Safety Products Limited | Administrative & support | 1996 |
| SER Management Company Ltd | Real estate | 2023 |
| Servicepower (Holdings) Limited | Financial services | 2019 |
| Servicepower Limited | Manufacturing | 1986 |
| Servisource Ltd. | Administrative & support | 2005 |
| Sessions Car Sales Limited | Wholesale & retail | 2024 |
| Settle & Carlisle Railway Company Limited(The) | Hospitality | 1984 |
| Sevenacres Livestock Limited | Agriculture & fishing | 2014 |
| SEW Outdoorsy Limited | Professional & scientific | 2020 |
| Sezro Ltd | Wholesale & retail | 2025 |
| SF Drainage Solutions Ltd | Water & waste | 2025 |
| SF Technology Supplies and Services Ltd | Manufacturing | 2018 |
| SFB Engineering Ltd | Manufacturing | 2025 |
| SFS Heritage Limited | Real estate | 2008 |
| SH Financial Ltd | Administrative & support | 2025 |
| SH Quality Joinery Ltd | Construction | 2007 |
| Shadan Personal Trainer Ltd | Arts & recreation | 2018 |
| Sharp & Griffiths Limited | Real estate | 1920 |