| CSL Webster Ltd | Construction | 2023 |
| Cuckoo Livery Limited | Agriculture & fishing | 2021 |
| Cuisine-Europe Limited | Wholesale & retail | 2010 |
| Culdrose Properties Ltd | Real estate | 2019 |
| Curators of Taste Limited | Wholesale & retail | 2022 |
| Cynegy (UK) Science & Technology Ltd | Wholesale & retail | 2022 |
| Cyzer Art Advisory Limited | Wholesale & retail | 2014 |
| D.O.Stewart Limited | Real estate | 1958 |
| Dada Projects Limited | Professional & scientific | 2021 |
| Dairy Moon Developments Ltd | Construction | 2025 |
| Dairyserve Limited | Other services | 2011 |
| Dalwood Court Management Company Limited | Wholesale & retail | 2006 |
| DAN Tytheridge Groundworks Ltd | Construction | 2019 |
| Daniel Potts Ltd | Information & communication | 2018 |
| Daniella Jones Ltd | Health & social care | 2021 |
| Daredevil Books Limited | Information & communication | 2021 |
| Dartmouth LVA LLP | | 2017 |
| Datum Building Services Ltd | Construction | 2017 |
| Davey Procurement Services Ltd | Construction | 2010 |
| David Evans Plumbing & Heating Limited | Construction | 2003 |
| David Gidney Consulting Limited | Professional & scientific | 2012 |
| David Webb Engineering Limited | Wholesale & retail | 2012 |
| DD Energy Solutions Ltd | Manufacturing | 2025 |
| DE Metz Consulting Limited | Information & communication | 2026 |
| De-Novo Consultants Limited | Professional & scientific | 2004 |
| Dean Furzey Limited | Construction | 2006 |
| Defiance Strategy Limited | Information & communication | 2025 |
| Defined Landscapes Limited | Administrative & support | 2025 |
| Dennett Holdings Limited | Financial services | 2023 |
| Denton-Powell Limited | Manufacturing | 2015 |
| Destination Travel (Wincanton) Limited | Transport & logistics | 2006 |
| Destination:Opera CIC | Education | 2023 |
| Development Impact Ltd | Professional & scientific | 2015 |
| Deverills Sporting Club Ltd | Arts & recreation | 2022 |
| Devon General Omnibus & Touring Company Limited | Transport & logistics | 2009 |
| DGN Studio Ltd | Professional & scientific | 2014 |
| Diacut Limited | Construction | 2003 |
| Dilton Marsh LVA LLP | | 2020 |
| Dilusi Solutions Limited | Information & communication | 2009 |
| DJD Training Consultants Limited | Administrative & support | 2009 |
| Dmdc Limited | Information & communication | 2022 |
| DNA Southwest Holdings Limited | Financial services | 2025 |
| Dockside Personnel Ltd | Administrative & support | 2008 |
| Dodge@Home Limited | Wholesale & retail | 2013 |
| Dokic Joinery Limited | Manufacturing | 2000 |
| Donna Andreana Ltd | Other services | 2023 |
| Dorber Limited | Real estate | 2021 |
| Dorotkas Dance Kingdom Limited | Professional & scientific | 2025 |
| Dorset Artisan Markets Limited | Wholesale & retail | 2022 |
| Dorset Garden Fencing Ltd | Construction | 2021 |
| Dorset Mechanical Limited | Construction | 2013 |
| Dorset Spray Renders Limited | Construction | 2017 |
| Dougdale Ltd | Hospitality | 2016 |
| Drayton's Decorations Limited | Real estate | 1953 |
| Dream Property Escapes Limited | Real estate | 2021 |
| Dryad Habitat & Ecology Limited | Professional & scientific | 2019 |
| DS Advisory Services Limited | Professional & scientific | 2017 |
| Dwellings of Sherborne Ltd | Construction | 2020 |
| Dynamonics Ltd | Professional & scientific | 2023 |
| East Brent LVA LLP | | 2017 |
| East Burton Estates Limited(The) | Real estate | 1947 |
| East Coker Estates Ltd | Construction | 2022 |
| Eastment Managerial Maintenance Company Limited | Professional & scientific | 1982 |
| EDA Holdings Limited | Financial services | 2024 |
| Eden Athletic Limited | Manufacturing | 2024 |
| Eden Properties (Tisbury) Ltd | Construction | 2002 |
| Edventure Travel Limited | Administrative & support | 2017 |
| Edward Hurst Limited | Wholesale & retail | 2016 |
| EHO Support (SW) Ltd | Professional & scientific | 2024 |
| Ekul Limited | Construction | 2021 |
| EL Sistema Sherborne Community Interest Company | Education | 2024 |
| Elite Cleaning Group Ltd | Other services | 2014 |
| Elite Farriery Limited | Agriculture & fishing | 2025 |
| Elite Flooring Solutions Southern Ltd | Construction | 2024 |
| Elle Nage Limited | Wholesale & retail | 2021 |
| Ember & Ice Studios Limited | Other services | 2026 |
| Emerald Green Renewables Limited | Construction | 2023 |
| Emil EVE Architects Limited | Professional & scientific | 2012 |
| Emma Keys Portraits Ltd | Arts & recreation | 2023 |
| Emma Lake Limited | Extraterritorial | 2012 |
| EMU Technologies (Europe) Limited | Manufacturing | 2005 |
| Enchanted Care Ltd | Health & social care | 2025 |
| English Country Gardens Ltd | Wholesale & retail | 2022 |
| Enviroboom Ltd | Manufacturing | 2022 |
| Eucan Community Interest Company | Education | 2011 |
| Evans & Pearce Limited | Agriculture & fishing | 1986 |
| Evro Publishing Limited | Information & communication | 2013 |
| Excel Shop Fitters (UK) Limited | Construction | 2006 |
| Exoria Engineering Ltd | Professional & scientific | 2025 |
| Express Motor Parts Limited | Wholesale & retail | 1993 |
| Exprm Limited | Administrative & support | 2010 |
| EYE FO Limited | Wholesale & retail | 1998 |
| F & G Properties Ltd | Real estate | 2017 |
| F Cuff & Sons Limited | Construction | 2002 |
| Fallen Stock Collection Ltd | Agriculture & fishing | 2021 |
| Fallow Workshops Ltd | Manufacturing | 2020 |
| Farley Solutions Limited | Professional & scientific | 2007 |
| FAY Roofing Limited | Construction | 2007 |
| Ferdi's Indoor Play Limited | Health & social care | 2025 |
| Ferma Farm Shop & Bistro Ltd | Wholesale & retail | 2024 |