| Roxana Punga Ltd | Health & social care | 2024 |
| RR Finance Consulting Ltd | Professional & scientific | 2025 |
| Ruggs Drove Renewables Limited | Energy | 2025 |
| Rush Wall Solar Park Limited | Energy | 2017 |
| Ruskin House Company Services Ltd | Professional & scientific | 1998 |
| S & B Transport Services Limited | Transport & logistics | 2009 |
| S C T Wheeler Limited | Manufacturing | 2000 |
| S L C P Ltd | Health & social care | 2024 |
| S Llewellyn Mobile Plant Engineers Limited | Wholesale & retail | 2021 |
| S&S Southwest Construction Ltd | Construction | 2023 |
| S. T & T Engineering Services Limited | Manufacturing | 2008 |
| Sagacious Limited | Extraterritorial | 1990 |
| Saint Thomas Renewables Limited | Energy | 2025 |
| Salcombe Sea Salt Ltd | Manufacturing | 2026 |
| Salus Safety Limited | Administrative & support | 2019 |
| SAM Claydon Games Ltd | Information & communication | 2022 |
| Samtech Industries Limited | Extraterritorial | 2020 |
| Santa Barbara Company Limited | Health & social care | 2014 |
| Sarah Tompkins Property Agents Ltd | Real estate | 2024 |
| Saturday Financial Ltd | Financial services | 2020 |
| Scagglethorpe Renewables Limited | Energy | 2025 |
| Scarlet Ice Retail Ltd | Wholesale & retail | 2026 |
| Scartho Group Ltd | Administrative & support | 2024 |
| Scartho Projects Ltd | Administrative & support | 2024 |
| Scasler Property Investment Ltd | Real estate | 2018 |
| SCR Global Group Ltd | Wholesale & retail | 2024 |
| Sea Breeze Holiday Cottages Ltd | Hospitality | 2023 |
| Seamap (U.K.) Limited | Manufacturing | 1990 |
| Seamless Productions Ltd | Arts & recreation | 2017 |
| Sedgbeer Ltd | Manufacturing | 2025 |
| Seed Invesco Limited | Manufacturing | 2012 |
| Selarg Limited | Real estate | 2021 |
| Selwood Care Ltd. | Health & social care | 2017 |
| Serious Music UK Limited | Arts & recreation | 1997 |
| Seventeen Hands Media Limited | Manufacturing | 2022 |
| SGS Application Partners Limited | Information & communication | 2001 |
| Shangri-La Events Limited | Arts & recreation | 2017 |
| Shartrack Aviation Ltd | Professional & scientific | 2022 |
| Shaws Tractors and Machinery Limited | Wholesale & retail | 2021 |
| Shealand Property Management Limited | Households | 1988 |
| Shelfbar Limited | Manufacturing | 2005 |
| Shepton (Somerset) Holdings Ltd | Real estate | 2015 |
| Shepton and Wells (Holdings) Limited | Professional & scientific | 2021 |
| Shepton Brasserie & Cafe Bar Ltd | Hospitality | 2015 |
| Shepton Community Bookshop CIC | Wholesale & retail | 2019 |
| Shepton Garage Limited | Wholesale & retail | 2025 |
| Shepton Mallet Car Sale Ltd | Wholesale & retail | 2025 |
| Shepton Mallet Community Enterprises CIC | Hospitality | 2022 |
| Shepton Mallet Community Woodland | Other services | 2016 |
| Shepton Mallet Landscape Limited | Administrative & support | 2014 |
| Shepton Mallet LC Ltd | Wholesale & retail | 2021 |
| Shepton Mallet Snowdrop Project CIC | Administrative & support | 2019 |
| Shepton Mallet Town Board Limited | Other services | 2026 |
| Shepton Mallet Town Football Club Ltd | Arts & recreation | 2026 |
| Shepton Veterinary Group Limited | Professional & scientific | 2011 |
| Showerings Cider Mill Ltd | Professional & scientific | 2016 |
| Showerings Limited | Extraterritorial | 2022 |
| Shrouk El-Attar Consultancy Limited | Professional & scientific | 2023 |
| Shuttercraft Somerset Limited | Construction | 2015 |
| Silikhaya Ltd | Health & social care | 2022 |
| Silver END Renewables Limited | Energy | 2026 |
| Silver Ice Retail Ltd | Wholesale & retail | 2026 |
| Simon James Holdings Ltd | Financial services | 2000 |
| Simon James Ltd | Construction | 2019 |
| Simon Moore Engineering Ltd | Manufacturing | 1993 |
| Sirius Engineering Consultancy Services Limited | Professional & scientific | 2019 |
| SJ Consulting Services Ltd | Professional & scientific | 2026 |
| SKI Trips Limited | Administrative & support | 2017 |
| Skroofing&Building Limited | Construction | 2022 |
| SLM (Design & Engineering) Limited | Administrative & support | 2006 |
| Snowy Ltd | Health & social care | 2018 |
| SO Linda Limited | Wholesale & retail | 2025 |
| Sofas & Garden Furniture Wiltshire Ltd | Wholesale & retail | 2025 |
| Solar Farm Investments Limited | Other services | 2011 |
| Solar Park Holdings Limited | Financial services | 2015 |
| Solar Park Investments Limited | Administrative & support | 2011 |
| Solar Power Generation Limited | Professional & scientific | 2013 |
| Solarise Services Ltd | Construction | 2023 |
| Solent Lighthouse Services Ltd | Transport & logistics | 2025 |
| Somerset Cleaning Company Ltd | Administrative & support | 2017 |
| Somerset Community Foundation | Other services | 2002 |
| Somerset Drinks Limited | Wholesale & retail | 2023 |
| Somerset Farm Management LLP | | 2026 |
| Somerset Farmers Markets Ltd | Administrative & support | 1999 |
| Somerset Property Maintenance Limited | Administrative & support | 2015 |
| Somerset Skin Care Ltd | Health & social care | 2022 |
| Somerset Style Ltd | Wholesale & retail | 2023 |
| Somerset Trading Company (Southwest) Ltd | Wholesale & retail | 2021 |
| Sophisticated Solutions Partners LLP | | 2018 |
| South West Property Finders Ltd | Real estate | 2005 |
| South West Riding Community Interest Company | Education | 2014 |
| South West Stoves Ltd | Wholesale & retail | 2022 |
| Southwestcompetitions Ltd | Other services | 2025 |
| Space Works Interiors Ltd | Construction | 2017 |
| Sparkford Hand Carwash & Valeting Ltd | Other services | 2025 |
| Spedex Limited | Transport & logistics | 2006 |
| Spinnaker Events Ltd | Hospitality | 2021 |
| SPK Housing Limited | Real estate | 2021 |
| Spraybox(Somerset) Ltd | Construction | 2025 |
| Ssgirn Holdings Ltd | Financial services | 2025 |