| Drip Culture Limited | Manufacturing | 2025 |
| Drip Designers Ltd | Wholesale & retail | 2026 |
| Drishaun Holdings Limited | Professional & scientific | 2006 |
| Drive Gold Limited | Administrative & support | 2025 |
| Drive Motor Group Ltd | Wholesale & retail | 2025 |
| Driven F1 Ltd | Transport & logistics | 2015 |
| Driven Personnel Ltd | Professional & scientific | 2021 |
| Driveone Limited | Transport & logistics | 2024 |
| Driver & Transport Limited | Transport & logistics | 2019 |
| Driverfirst Logistics Ltd | Transport & logistics | 2026 |
| Drivevibe Driving School Ltd | Education | 2025 |
| Driveways Sheffield Ltd | Administrative & support | 2026 |
| Driving Arts Academy Ltd | Education | 2026 |
| DRM Healthcare Ltd | Health & social care | 2024 |
| Droneville Limited | Wholesale & retail | 2025 |
| Dronfield Carpets and Floors Limited | Wholesale & retail | 2017 |
| Dronfield Cooked Meats Limited | Wholesale & retail | 2001 |
| Dronfield Court Management Limited | Real estate | 1993 |
| Dronfield Development and Construction Company Limited | Construction | 1976 |
| Dronfield Hall Barn Ltd | Hospitality | 2023 |
| Dronfield Plastering Company Limited | Construction | 2019 |
| Drop Dead Clothing Limited | Wholesale & retail | 2006 |
| Dropforge Design Ltd | Professional & scientific | 2020 |
| DRS Events Limited | Administrative & support | 2015 |
| Drudio Studio Ltd | Professional & scientific | 2023 |
| Drum Intime Limited | Information & communication | 2025 |
| Drummond PUB Company Ltd | Hospitality | 2020 |
| Drumwave Ltd | Professional & scientific | 2026 |
| Drunken Horse GIN Limited | Wholesale & retail | 2021 |
| DRW Plastering ( Yorkshire ) Limited | Construction | 2013 |
| DRW Property and Investments Ltd | Other services | 2025 |
| DRY Stone Press Limited | Professional & scientific | 2018 |
| Dryad Works Ltd | Arts & recreation | 2018 |
| Drycraft Ltd | Information & communication | 2026 |
| Dryfix Interior Systems Ltd | Construction | 2019 |
| Dryft World Ltd | Manufacturing | 2018 |
| Drywall UK Limited | Professional & scientific | 2004 |
| DS Acquisitions Ltd | Construction | 2024 |
| DS Automobiles Ltd | Wholesale & retail | 2009 |
| DS Creative Ltd | Manufacturing | 2008 |
| DS Digital Print Ltd | Manufacturing | 2012 |
| DS Fashion and Beauty Empire Ltd | Extraterritorial | 2025 |
| DS Fitness Limited | Arts & recreation | 2025 |
| DS Group Ltd | Professional & scientific | 2024 |
| DS Healthcare Services Ltd | Health & social care | 2022 |
| DS IT Service Management Ltd | Information & communication | 2013 |
| DS Roofing and Building Solutions Limited | Construction | 2019 |
| DSA Group Holdings Limited | Financial services | 2016 |
| Dsbm Properties Ltd | Real estate | 2019 |
| DSD & Associates Ltd | Wholesale & retail | 2003 |
| DSD Property and Management Limited | Real estate | 2022 |
| DSE2ME Ltd | Administrative & support | 2020 |
| DSG Dog Spa Limited | Other services | 2026 |
| Dsgc Ltd | Manufacturing | 2024 |
| DSH Ventures Limited | Hospitality | 2025 |
| DSK Engineering Ltd | Professional & scientific | 2025 |
| DSL Screeding Limited | Construction | 2015 |
| Dsmj Heating, Plumbing & Building Services Ltd | Construction | 2022 |
| DSO Food Ltd | Wholesale & retail | 2018 |
| DSQ Consultancy Ltd | Professional & scientific | 2026 |
| Dsquire Ltd | Professional & scientific | 2025 |
| DSR IT Consultancy Ltd | Professional & scientific | 2005 |
| Dssm Eccles Ltd | Professional & scientific | 2019 |
| Dstephenson Services Limited | Administrative & support | 2021 |
| DSV Eccles Limited | Professional & scientific | 2018 |
| DT Clay Modelling Limited | Arts & recreation | 2017 |
| DT Doncaster Ltd | Hospitality | 2025 |
| DT Firth Park Ltd | Hospitality | 2026 |
| DT Firvale Ltd | Hospitality | 2026 |
| DT Hub Ltd | Hospitality | 2025 |
| DTA Wholesale Limited | Wholesale & retail | 2024 |
| DTC Carpets Limited | Wholesale & retail | 2024 |
| Dtcm Limited | Administrative & support | 2011 |
| Dtlive Ltd | Arts & recreation | 2024 |
| Dtop Pure Grace Limited | Health & social care | 2024 |
| DTR Accountancy Services Ltd | Professional & scientific | 2013 |
| DTT Services Limited | Health & social care | 2021 |
| Dtvm Ltd | Information & communication | 2017 |
| DU Apparel Ltd | Wholesale & retail | 2018 |
| DUA LOT Entertainment Ltd | Arts & recreation | 2011 |
| Dual Mixed Recycling Ltd | Water & waste | 2026 |
| Duality Brew Co Limited | Manufacturing | 2024 |
| Dualversity Ltd | Education | 2018 |
| Dubai Homes Ltd | Extraterritorial | 2025 |
| Dubai Night Limited | Hospitality | 2025 |
| Dubik Plumbing & Bathrooms Ltd | Construction | 2024 |
| Dubik Tiling Ltd | Construction | 2026 |
| Dubreelux Limited | Wholesale & retail | 2021 |
| Duck Soup Films Cardiff Limited | Information & communication | 2022 |
| Dudley Magee Group Limited | Construction | 2026 |
| Duel TEC Coaching Ltd | Arts & recreation | 2024 |
| Duffields Business Forms Limited | Manufacturing | 1987 |
| Duhele Transport Limited | Transport & logistics | 2026 |
| Duke Health & Safety Management Limited | Professional & scientific | 2002 |
| Dukebay Limited | Real estate | 1979 |
| Dukeries Aviation Management Limited | Manufacturing | 2009 |
| Dukhni Limited | Wholesale & retail | 2026 |
| Dulcify Ltd | Manufacturing | 2024 |
| Duman & Daughters Ltd | Other services | 2023 |
| Dumanli Cafe Ltd | Hospitality | 2025 |