| UR Trader Limited | Wholesale & retail | 2021 |
| Uranium AI Europe Limited | Information & communication | 2025 |
| Urba Homes Ltd | Real estate | 2019 |
| Urban Abseil Ltd | Construction | 2011 |
| Urban ARC Homes Project CIC | Health & social care | 2025 |
| Urban Beat Academy CIC | Education | 2025 |
| Urban Choola Limited | Hospitality | 2012 |
| Urban Digital Limited | Information & communication | 2023 |
| Urban Flex Ltd | Wholesale & retail | 2024 |
| Urban Fresh Pitta Limited | Hospitality | 2026 |
| Urban Garden Sheffield Ltd | Wholesale & retail | 2018 |
| Urban Illustrations Ltd | Professional & scientific | 2020 |
| Urban Kebab SY Ltd | Hospitality | 2025 |
| Urban Motorz Limited | Wholesale & retail | 2024 |
| Urban Property Lounge Ltd | Hospitality | 2017 |
| Urban Rental Properties Ltd | Construction | 2020 |
| Urban Retrofit Projects Ltd | Construction | 2014 |
| Urban Roofing Sheffield Limited | Construction | 2022 |
| Urban Security Limited | Administrative & support | 2025 |
| Urban Soul (UK) Limited | Real estate | 2014 |
| Urban Spacemen Limited | Administrative & support | 2013 |
| Urban Style Properties Limited | Real estate | 2008 |
| Urban Theology Union | Education | 2006 |
| Urban Trim 2 Ltd | Other services | 2026 |
| Urban Trim Ltd | Other services | 2024 |
| Urban Woodseats Ltd | Hospitality | 2025 |
| Urbana London Ltd | Professional & scientific | 2026 |
| Urbana Town Planning Limited | Professional & scientific | 2012 |
| Urbanbuy Limited | Wholesale & retail | 2022 |
| Urbanfusionbyellabella Ltd | Hospitality | 2020 |
| Urbanscan Limited | Information & communication | 2009 |
| Urbanside Limited | Wholesale & retail | 2024 |
| Urbanway Transport Ltd | Transport & logistics | 2026 |
| Urecsys UK Ltd | Administrative & support | 2024 |
| Uriah's Ltd | Hospitality | 2026 |
| Urmk Services Ltd | Wholesale & retail | 2024 |
| Urmston Carpets Limited | Transport & logistics | 2007 |
| URO Medical Ltd | Health & social care | 2017 |
| Uropanet Ltd | Information & communication | 2015 |
| URP Group Ltd | Construction | 2020 |
| Ursula Bidco Limited | Extraterritorial | 2025 |
| Ursula Midco Limited | Extraterritorial | 2025 |
| Ursula Parentco Limited | Extraterritorial | 2025 |
| Ursula Topco Limited | Extraterritorial | 2025 |
| Usaali&Co Ltd | Wholesale & retail | 2025 |
| USB Land Ltd | Real estate | 2018 |
| USB Ltd | Health & social care | 2015 |
| USE My Data | Health & social care | 2022 |
| Used Car 4 U Ltd | Wholesale & retail | 2023 |
| Used Steel Buildings Group Ltd | Construction | 2025 |
| Usefulu Ltd | Information & communication | 2023 |
| Useria Tech Limited | Information & communication | 2022 |
| Usherwood Treatment Room Ltd | Other services | 2020 |
| USI Service Limited | Wholesale & retail | 2014 |
| Usijali Limited | Real estate | 2021 |
| Usmaan Jewellers Ltd | Manufacturing | 2024 |
| Usman Khan Limited | Real estate | 2017 |
| Usmani's Financial Consultancy Ltd | Information & communication | 2025 |
| Ustore Holbrook Ltd | Transport & logistics | 2020 |
| Usual Suspects Ltd | Arts & recreation | 2011 |
| UTA Limited | Hospitality | 2022 |
| UTA Property Limited | Construction | 2024 |
| UTD Properties Limited | Real estate | 2018 |
| Utdhomes.Co.Uk (Sheffield) Ltd | Real estate | 2012 |
| Utilinet Limited | Professional & scientific | 2022 |
| Utility Hygiene BIN Cleaning Services Ltd | Other services | 2020 |
| Utility Support Limited | Wholesale & retail | 2018 |
| Utility Works Limited | Construction | 2024 |
| UTM Moorgate Ltd | Hospitality | 2023 |
| Utopia Construction and Landscaping Ltd | Administrative & support | 2021 |
| Utopia Martial Arts & Fitness Limited | Arts & recreation | 2019 |
| Uvana Technologies Ltd | Information & communication | 2026 |
| UVI Shopping Limited | Wholesale & retail | 2025 |
| UVM Limited | Arts & recreation | 2017 |
| UW Waste Management Ltd | Other services | 2018 |
| UWA Social Enterprise Limited | Health & social care | 2021 |
| UWM Wealth Management Limited | Financial services | 2014 |
| UYE (UK) Limited | Professional & scientific | 2009 |
| Uzaibkhan Ltd | Wholesale & retail | 2026 |
| Uzair Khalid Traders Ltd | Wholesale & retail | 2025 |
| Uzma Naqvi Life Coaching Ltd | Education | 2020 |
| V & K Accountancy Services Limited | Professional & scientific | 2012 |
| V C Property Limited | Real estate | 2004 |
| V E Psychotherapy Services Ltd | Education | 2026 |
| V J Collections Limited | Wholesale & retail | 2018 |
| V Naik & Co Ltd | Health & social care | 2024 |
| V Orliaklis Property Limited | Real estate | 2014 |
| V R Leisure Ltd | Arts & recreation | 2020 |
| V S Bazar Ltd | Wholesale & retail | 2025 |
| V Side Invest Ltd | Real estate | 2025 |
| V&W Business Ltd | Hospitality | 2025 |
| V-Edition Media Ltd | Information & communication | 2012 |
| V. & a. Tamhankar Ltd | Health & social care | 2016 |
| V. Orliaklis Limited | Health & social care | 2010 |
| V. Sabatier Limited | Extraterritorial | 1986 |
| V.A.G Brake & Trade Ltd | Wholesale & retail | 2025 |
| V.C.S. Car Park Management Limited | Transport & logistics | 1991 |
| V.M.L Engineering Limited | Manufacturing | 2001 |
| V22 Property Investments Limited | Real estate | 2024 |
| V300 Clinical Mentors Ltd | Professional & scientific | 2025 |