| THE Savage Sister Limited | Wholesale & retail | 2024 |
| THE Scar Production Ltd | Information & communication | 2023 |
| THE School House (S35) RTM Company Limited | Households | 2024 |
| THE Schoolrooms Bradfield Limited | Wholesale & retail | 2009 |
| THE Scout and Guide Shop Limited | Wholesale & retail | 1997 |
| THE Scransit Van Ltd | Arts & recreation | 2026 |
| THE Seagulls Musical Ocean Limited | Information & communication | 2017 |
| THE Second Burlington Close (Dore) Management Company Limited | Real estate | 2023 |
| THE Secret Beauty Academy Ltd | Education | 2019 |
| THE Secret Beauty Club UK Ltd | Administrative & support | 2019 |
| THE Secret Beauty Store Ltd | Wholesale & retail | 2021 |
| THE Secret Brow Company Limited | Other services | 2016 |
| THE Secret Designer Limited | Construction | 2018 |
| THE Seer and the Seen Ltd | Wholesale & retail | 2020 |
| THE Self Leadership Initiative Ltd | Education | 2014 |
| THE Sensoria Festival | Arts & recreation | 2008 |
| THE SEO Works (EOT) Ltd | Financial services | 2025 |
| THE SEO Works Ltd | Information & communication | 2009 |
| THE Sharrow Steak & Grill Ltd | Hospitality | 2026 |
| THE Sharrow Vale Trading Company Limited | Wholesale & retail | 2018 |
| THE Shed Gym & Fitness Ltd | Arts & recreation | 2023 |
| THE Shef Table Ltd | Hospitality | 2024 |
| THE Sheff Cutlery Shop Ltd | Manufacturing | 2025 |
| THE Sheffield and District Society of Model and Experimental Engineers Limited | Professional & scientific | 1993 |
| THE Sheffield Bath Company Limited | Other services | 2002 |
| THE Sheffield BED Co Limited | Extraterritorial | 2022 |
| THE Sheffield Bolthole Ltd | Hospitality | 2024 |
| THE Sheffield Brewery Company Limited | Manufacturing | 2006 |
| THE Sheffield CAB Company Limited | Wholesale & retail | 2011 |
| THE Sheffield Cats Shelter | Other services | 2016 |
| THE Sheffield Centre of Education Ltd | Education | 2017 |
| THE Sheffield Christmas Tree (PYO) Company Limited | Agriculture & fishing | 2016 |
| THE Sheffield Clinic Ltd | Health & social care | 2006 |
| THE Sheffield Hospice Limited | Health & social care | 2007 |
| THE Sheffield Music Store Limited | Wholesale & retail | 2025 |
| THE Sheffield Retired Greyhounds Limited | Other services | 2022 |
| THE Sheffield Royal Society for the Blind | Health & social care | 1995 |
| THE Sheffield Saleroom Limited | Administrative & support | 2009 |
| THE Sheffield United Football Club Limited | Arts & recreation | 1899 |
| THE Sheffield UTC Academy Trust | Education | 2011 |
| THE Shelter Whirlowbrook Cafe Ltd | Hospitality | 2023 |
| THE Sherwood Flat Management Co. Ltd. | Households | 1993 |
| THE Ship Inn (Jones) Ltd | Hospitality | 2023 |
| THE Simply Fresh UK PVT Ltd | Wholesale & retail | 2020 |
| THE Skin Firm Ltd | Health & social care | 2023 |
| THE Slovak Food Shop Limited | Wholesale & retail | 2025 |
| THE Snapbox Ltd | Professional & scientific | 2023 |
| THE Socially Impactful CIC | Administrative & support | 2021 |
| THE Society of Indexers | Other services | 2007 |
| THE Solution Engineering Limited | Professional & scientific | 2014 |
| THE Sound of Everything Limited | Information & communication | 2014 |
| THE Sound of Everything Publishing Limited | Information & communication | 2014 |
| THE Sourcing Circle Ltd | Real estate | 2019 |
| THE South London Co-Operative Building Company Limited | Real estate | 1866 |
| THE South West Climbing Competition Series Ltd | Arts & recreation | 2026 |
| THE South Yorkshire Filmmakers' Network | Information & communication | 2004 |
| THE Southey Development Forum Limited | Other services | 2008 |
| THE Spa 493 Ltd | Other services | 2025 |
| THE Spa Doctor Ltd | Other services | 2011 |
| THE Spectrum Building Management Company Limited | Households | 2001 |
| THE Spinney (Dore) Management Company Limited | Households | 2013 |
| THE Spirit Beer Company Limited | Wholesale & retail | 2016 |
| THE Spirit Run Limited | Wholesale & retail | 2025 |
| THE Stamp House Limited | Real estate | 2021 |
| THE Start-Up Loans Company | Financial services | 2012 |
| THE Station Kiveton Ltd | Hospitality | 2023 |
| THE Steel Artisans Ltd | Manufacturing | 2025 |
| THE Steel Cauldron Ltd | Hospitality | 2020 |
| THE Steel Spoon Ltd | Hospitality | 2024 |
| THE Steel Valley Project | Other services | 2002 |
| THE Steelhouse Management Limited | Households | 2004 |
| THE Stephenson Property Group Limited | Real estate | 2024 |
| THE Stitch Factory Limited | Administrative & support | 2003 |
| THE Stitch Studio & Born-Again Boutique Ltd | Manufacturing | 2025 |
| THE Stolen Photon Ltd | Manufacturing | 2019 |
| THE Strad Family Entertainment Room and Bar Ltd | Hospitality | 2025 |
| THE Street Food Chef Limited | Wholesale & retail | 2012 |
| THE Study Studio LLP | | 2026 |
| THE Study Studio Resources Ltd | Education | 2026 |
| THE Stuffed Walrus PUB Ltd | Hospitality | 2024 |
| THE Style Lounge 01 Limited | Other services | 2024 |
| THE Style Lounge NO.2 Limited | Other services | 2025 |
| THE Sunset Shutter Co. Ltd | Construction | 2025 |
| THE Surgical Practice Limited | Health & social care | 2010 |
| THE Sweet Cartel Ltd | Hospitality | 2026 |
| THE Tailored and Patched Table Limited | Hospitality | 2026 |
| THE TAJ Mahal Curry House Ltd | Hospitality | 2024 |
| THE Tame Teapot Ltd | Wholesale & retail | 2025 |
| THE TAN Station (Operations) Ltd | Professional & scientific | 2026 |
| THE TAN Station Chesterfield Ltd | Other services | 2026 |
| THE TAN Station Ltd | Financial services | 2026 |
| THE Tanning Group Ltd | Administrative & support | 2010 |
| THE Tawny Bar Ltd | Hospitality | 2025 |
| THE Tax Team Limited | Professional & scientific | 2001 |
| THE Taylor Collective Limited | Financial services | 2024 |
| THE Tech Booth Ltd | Other services | 2019 |
| THE Third MAN Collective Limited | Wholesale & retail | 2026 |
| THE Thirsty Badger Company Limited | Hospitality | 2014 |
| THE Thorncliffe Garage Limited | Wholesale & retail | 2022 |
| THE Thornhill Arms Limited | Hospitality | 2020 |