| Meadowhead Carpets and Vinyls Limited | Wholesale & retail | 2023 |
| Meadowhead Community Learning Trust | Education | 2009 |
| Meadowhead Foods Ltd | Hospitality | 2025 |
| Meadowhead School Academy Trust | Education | 2012 |
| Meadows Bakery Ltd | Other services | 2007 |
| Meadows Management Limited(The) | Households | 1984 |
| Meap Innovation Ltd | Professional & scientific | 2022 |
| Meat the Company Limited | Extraterritorial | 2010 |
| Meats and Greens Ltd | Wholesale & retail | 2025 |
| MEC Contractors Ltd | Construction | 2023 |
| MEC Solutions Ltd | Real estate | 2012 |
| Mechan Group Limited | Professional & scientific | 2007 |
| Mechan Limited | Manufacturing | 1969 |
| Mechanica Limited | Professional & scientific | 2024 |
| Mechaquip Limited | Administrative & support | 2003 |
| Meco Construction Ltd | Construction | 2025 |
| Meco Property Ltd | Real estate | 2010 |
| MED Street Food Limited | Hospitality | 2022 |
| Med-El UK Limited | Wholesale & retail | 1993 |
| Medarrow Solutions Ltd | Wholesale & retail | 2025 |
| Medbase Ltd | Administrative & support | 2013 |
| Medbrook Limited | Professional & scientific | 2024 |
| Medburao Ltd | Health & social care | 2020 |
| MEDEGY1 Limited | Health & social care | 2025 |
| Medex (Group) Ltd | Education | 2010 |
| Medex Learning Limited | Education | 2012 |
| Medex Medical Services Ltd | Health & social care | 2019 |
| Medexs Medical Systems Ltd | Manufacturing | 2013 |
| Medezine Holdings Ltd | Professional & scientific | 2014 |
| Medezine Limited | Manufacturing | 1989 |
| Medfoodco Ltd | Hospitality | 2015 |
| Medi Recruitment Ltd | | 2010 |
| Medi Urban Rest & Cafe Ltd | Hospitality | 2026 |
| Media Forever Ltd | Professional & scientific | 2015 |
| Media Logic Limited | Information & communication | 1996 |
| Media Thinking Limited | Administrative & support | 2009 |
| Media Vision NO 1. Ltd | Professional & scientific | 2013 |
| Mediafellas Ltd | Professional & scientific | 2018 |
| Mediafun Limited | Professional & scientific | 1999 |
| Mediapharm Ltd | Professional & scientific | 2003 |
| Mediashy Ltd | Households | 2007 |
| Medibee Ltd. | Wholesale & retail | 2005 |
| Medic MA Ltd | Health & social care | 2024 |
| Medical Business Consulting Limited | Information & communication | 2011 |
| Medical Device Solutions Ltd | Manufacturing | 2013 |
| Medical Employment Assist Limited | Professional & scientific | 2017 |
| Medical Equipment Manufacturers (Sheffield) Limited | Other services | 1983 |
| Medical Kinetics Ltd | Health & social care | 2020 |
| Medical Negligence Compensation Limited | Professional & scientific | 2011 |
| Medical Solicitors Limited | Professional & scientific | 2009 |
| Medicalport Ltd | Wholesale & retail | 2013 |
| Mediceye Ltd | Health & social care | 2017 |
| Medico Legal Records Limited | Professional & scientific | 1995 |
| Medico Legal Rehab Limited | Health & social care | 2015 |
| Medicolegal Direct Reports Limited | Health & social care | 2012 |
| Medicolegal Radiology Ltd | Administrative & support | 2017 |
| Medicspire Limited | Health & social care | 2025 |
| Medidento Ltd | Health & social care | 2023 |
| Mediena Limited | Professional & scientific | 2012 |
| Mediface Aesthetics Ltd | Health & social care | 2018 |
| Mediface Skin Limited | Health & social care | 2020 |
| Medifast Delivery Limited | Wholesale & retail | 2021 |
| Mediglob Limited | Financial services | 2019 |
| Medihive UK Limited | Information & communication | 2022 |
| Mediked Ltd | Health & social care | 2022 |
| Medilink North of England Limited | Other services | 1997 |
| Mediplan Limited | Manufacturing | 1992 |
| Medis Diagnostics Ltd | Professional & scientific | 2000 |
| Medispa Aesthetics Ltd | Health & social care | 2021 |
| Medispa Holdings Limited | Health & social care | 2022 |
| Medisun Limited | Wholesale & retail | 2001 |
| Meditech Holdings Limited | Wholesale & retail | 2021 |
| Meditech Innovations Limited | Wholesale & retail | 2009 |
| Mediterranean South Enterprise Ltd | Extraterritorial | 2018 |
| Mediumrare Entertainment Limited | Arts & recreation | 2005 |
| Medloc Ltd | Health & social care | 2019 |
| Medlock Court Residents Company Limited | Households | 2001 |
| Medlock Road Management Company Ltd | Households | 2023 |
| Medpass Academy Ltd | Education | 2024 |
| Medqon Limited | Information & communication | 2019 |
| Meds & Care Ltd | Wholesale & retail | 2024 |
| Medsim Consulting Limited | Professional & scientific | 2025 |
| Medtech Integrity Limited | Professional & scientific | 2024 |
| Medtour UK Ltd | Health & social care | 2023 |
| Medur Limited | Health & social care | 2020 |
| Medusa Greek Food Limited | Hospitality | 2022 |
| Medya Ltd | Hospitality | 2017 |
| Meemo Global Ltd | Wholesale & retail | 2024 |
| Meer Housing Limited | Real estate | 2025 |
| Meeran & Rasheed Properties Limited | Real estate | 2023 |
| Meeran Properties Limited | Real estate | 2022 |
| Meersbrook Bowling Club Limited(The) | Arts & recreation | 1884 |
| Meersbrook Construction Company Limited | Construction | 1980 |
| Meersbrook Enterprise Centre Limited | Real estate | 1980 |
| Meersbrook Park Breakfast & After School Club | Education | 2025 |
| Meersbrook Training & Coaching Ltd | Professional & scientific | 2025 |
| Meet at Rita Limited | Hospitality | 2026 |
| Meet S&P Limited | Hospitality | 2025 |
| Meet Success Coach Limited | Health & social care | 2023 |
| Meet U Ltd | Wholesale & retail | 2024 |