| Scent Shot Ltd | Wholesale & retail | 2024 |
| SCJ Consulting Ltd | Professional & scientific | 2023 |
| Scorpion Media Group Ltd | Information & communication | 2025 |
| Scott Electrical Contractors Ltd | Construction | 2024 |
| Scott to BE Clean Ltd | Administrative & support | 2025 |
| Scott.Harris Highways Solutions Limited | Construction | 2017 |
| Scotts Scaffold Inspections Ltd | Construction | 2026 |
| Scrum Chic Ltd | Professional & scientific | 2025 |
| Scuba Scanner Ltd | Wholesale & retail | 2024 |
| Scurfield Construction Limited | Construction | 2022 |
| Seacliff Holiday Estate Limited | Hospitality | 1963 |
| Seaholm Logistics Ltd | Transport & logistics | 2016 |
| Sealine Taxis UK Limited | Transport & logistics | 2018 |
| Sealover Ltd | Real estate | 2025 |
| Secu Logistics Ltd | Transport & logistics | 2020 |
| Seekintel Data Ltd | Professional & scientific | 2024 |
| Seeway Security Ltd | Administrative & support | 2025 |
| Selcuk Holdings Limited | Real estate | 2012 |
| Sensible Property Construction Ltd | Construction | 2024 |
| Sensible Property Investments Limited | Real estate | 2017 |
| Sensu Hair & Beauty Limited | Other services | 2021 |
| Seven Hills Sales Ltd | Real estate | 2019 |
| Seven Stars 2018 Limited | Transport & logistics | 2018 |
| Sharrock Insurance Services Limited | Financial services | 2009 |
| Shayona Healthcare Ltd | Wholesale & retail | 2016 |
| Shean Haulage Ltd | Transport & logistics | 2019 |
| Sheerness Dockyard Preservation Trust | Arts & recreation | 2014 |
| Sheerness Fish Bar & Pizza Limited | Hospitality | 2026 |
| Sheerness Golf Club Limited | Real estate | 1946 |
| Sheerness Groups Ltd | Wholesale & retail | 2026 |
| Sheerness Historic Docks Residential Quarter Management Co Limited | Manufacturing | 2014 |
| Sheerness Holiday Park Limited | Hospitality | 1989 |
| Sheerness Mobility Limited | Wholesale & retail | 2019 |
| Sheerness Storage Solutions Ltd | Wholesale & retail | 1989 |
| Sheppard's Way Property Management Ltd | Real estate | 2024 |
| Sheppey Barbers Ltd | Other services | 2025 |
| Sheppey Caravans Ltd | Manufacturing | 2019 |
| Sheppey GAS & Heating Limited | Wholesale & retail | 2018 |
| Sheppey Greens Ltd | Wholesale & retail | 2024 |
| Sheppey Hire Centre Ltd | Construction | 2019 |
| Sheppey Leisure Ltd | Arts & recreation | 2022 |
| Sheppey Lettings Limited | Real estate | 2017 |
| Sheppey Matters | Health & social care | 2000 |
| Sheppey Motor Salvage & Spares Limited | Wholesale & retail | 2025 |
| Sheppey Natural Burial Ground Limited | Other services | 2017 |
| Sheppey Properties Ltd | Real estate | 2025 |
| Sheppey Vape Store Ltd | Wholesale & retail | 2015 |
| Sheppeyz Ltd | Hospitality | 2018 |
| Sheppy Glass Centre Limited | Wholesale & retail | 1972 |
| Sheridan & Bailey Property Management Ltd | Households | 2025 |
| Sherlock Homes Construction Limited | Construction | 2017 |
| Shield Fire Protection Ltd | Public administration | 2025 |
| Shiny B Ltd | Administrative & support | 2023 |
| Shisha Bar Kent Limited | Wholesale & retail | 2022 |
| Shiver of Sharks Limited | Wholesale & retail | 2021 |
| SHJ Services Limited | Real estate | 2018 |
| Shoogz in the House Ltd | Real estate | 2023 |
| Shoogz Productions Limited | Information & communication | 2020 |
| Shurland Building & Landscaping Ltd | Construction | 2025 |
| Sie-Lu Limited | Construction | 2018 |
| Simon Durnford Joinery and Services Limited | Manufacturing | 2025 |
| Sitrock Limited | Administrative & support | 2008 |
| Sixthstop Ltd | Wholesale & retail | 2025 |
| Sjak Estates Limited | Real estate | 2025 |
| SJS Motor Company Kent Ltd | Wholesale & retail | 2021 |
| SJV Estates Ltd | Real estate | 2021 |
| SK Real Ltd | Real estate | 2023 |
| Skilled Cleaners Ltd | Administrative & support | 2024 |
| Skills Care UK Limited | Education | 2017 |
| Skills Inc. Limited | Professional & scientific | 2021 |
| Skills Knowledge Innovation Limited | Public administration | 2012 |
| Skinner Electrical Ltd | Construction | 2017 |
| SKJ Construction Ltd | Construction | 2025 |
| Sling YA Hook Charters Ltd | Transport & logistics | 2024 |
| Sling YA Hook Ltd | Wholesale & retail | 2022 |
| Small Business H&S Consultancy Ltd | Professional & scientific | 2021 |
| Small Dog Rescue & Rehome Ltd | Other services | 2020 |
| Smart Choice Properties Investment Limited | Real estate | 2022 |
| Smart Estimator Ltd | Information & communication | 2019 |
| Smart Pest Control Ltd | Administrative & support | 2017 |
| Smillie Groundworks Limited | Construction | 2009 |
| Smith & Jones Advisory Limited | Professional & scientific | 2026 |
| Smith Gowdy Electrical Limited | Construction | 2009 |
| Smith Gowdy Holdings Limited | Real estate | 2025 |
| Snowdown Park Ltd | Construction | 2018 |
| Socialriser Ltd | Professional & scientific | 2020 |
| Solvit Techne Solutions Ltd | Information & communication | 2025 |
| Something About Bricks Ltd | Wholesale & retail | 2023 |
| Sonny Holdings Ltd | Hospitality | 2020 |
| Soper and Sons Ltd | Wholesale & retail | 2020 |
| Sophie at S.W.A.L.K. Cards & Gifts Limited | Wholesale & retail | 2022 |
| South East Hydraulics Ltd | Wholesale & retail | 2022 |
| South Eastern Imperial Home Solutions Ltd | Construction | 2018 |
| South Leas Developments Ltd | Construction | 2016 |
| Southeastern Drilling Services Ltd | Construction | 2009 |
| Southeastlocksmiths Limited | Construction | 2017 |
| Southern Commercials Limited | Wholesale & retail | 2009 |
| Southern Commercials Van Sales Ltd | Wholesale & retail | 2017 |
| Southern Conversions Ltd | Manufacturing | 2022 |
| Southern Fires Ltd | Wholesale & retail | 2015 |