| Sander Glass Limited | Wholesale & retail | 2015 |
| Sandhill Homes (Lillesden) Limited | Construction | 2018 |
| Sandra Atkins Limited | Information & communication | 2021 |
| Sands Residentialproperties Limited | Construction | 2024 |
| Sandwich Bay Estate Limited | Extraterritorial | 1928 |
| Sani Care Protection Services UK Ltd | Wholesale & retail | 2021 |
| Sanpel Limited | Financial services | 2026 |
| SAP Electrical Solutions Limited | Construction | 2009 |
| Sarah Garth Limited | Administrative & support | 2021 |
| Sarah Rabbidge Limited | Professional & scientific | 2015 |
| Sarasun UK Ltd | Wholesale & retail | 2019 |
| SAS Academy Ltd | Education | 2024 |
| Sauced GTM & Technical Recruitment Solutions Limited | Administrative & support | 2025 |
| Sauced Technology Recruitment Solutions Ltd | Administrative & support | 2021 |
| Saunton Investments Limited | Financial services | 2016 |
| Savoy Business Services Ltd | Professional & scientific | 2013 |
| Saxon Kent Ltd | Water & waste | 2026 |
| Saxondene Ltd | Professional & scientific | 2025 |
| Saywest Ltd | Health & social care | 2010 |
| SB Trading Kent Ltd | Public administration | 2023 |
| Sbclinic Ltd | Health & social care | 2015 |
| SBH Security Ltd | Administrative & support | 2007 |
| SBJ New Holdings Limited | Financial services | 2025 |
| SBL Crypto Ltd | Financial services | 2021 |
| SBL Plumbing & Heating Ltd | Construction | 2020 |
| SC106 Ltd | Professional & scientific | 2011 |
| Scalecraft AI Ltd | Information & communication | 2025 |
| Scaled EVO Limited | Professional & scientific | 2024 |
| Scaled Insight Ltd | Information & communication | 2011 |
| Scealu Limited | Professional & scientific | 2024 |
| Scene & Story Ltd | Professional & scientific | 2025 |
| Schaartanning Ltd | Other services | 2023 |
| School Sport Education Ltd | Arts & recreation | 2018 |
| Scintec Communications Ltd | Professional & scientific | 2010 |
| Scintilla Derivatives Ltd | Administrative & support | 2011 |
| Scmac Limited | Education | 2021 |
| Scotam Atlantic Business Development Advisors Limited Partnership | | 1995 |
| Scott Castle Electrical Ltd | Construction | 2024 |
| Scottimber Ltd | Extraterritorial | 2018 |
| Screen ADS Limited | Professional & scientific | 2018 |
| Screenprojex Limited | Information & communication | 2002 |
| Screentek Limited | Wholesale & retail | 2015 |
| SCT Property Investments Limited | Real estate | 2021 |
| SDG Ltd | Real estate | 2021 |
| SDH Listings Limited | Professional & scientific | 2020 |
| SDL GAS Services Limited | Manufacturing | 2006 |
| SE13 Records Limited | Information & communication | 2011 |
| Sea Garden (Hope Cove) Limited | Real estate | 2004 |
| Sea Green Law Ltd | Professional & scientific | 2018 |
| Sea Green Shipping and Commodities Consulting Limited | Professional & scientific | 2018 |
| Seaby Trading (UK) Ltd | Administrative & support | 2016 |
| Seacare Okiki London Co. Ltd | Wholesale & retail | 2025 |
| Seagrove Capital Ltd | Construction | 2022 |
| Seam Architects Limited | Professional & scientific | 2011 |
| Seatown Films Limited | Information & communication | 2013 |
| Secret Collectors Network Ltd | Information & communication | 2026 |
| Secure Fields Ltd | Real estate | 2020 |
| Sedding Limited | Professional & scientific | 2020 |
| Seene Limited | Information & communication | 2023 |
| Seerungen Consulting Limited | Construction | 2017 |
| Sees Education Consultancy Ltd | Education | 2026 |
| Sefer(Hotels)Limited | Hospitality | 1965 |
| Seivad Property Limited | Real estate | 2017 |
| Sekuir UK Ltd | Financial services | 2025 |
| Select Nishikigoi International Limited | Wholesale & retail | 2006 |
| Selective Property Investments Ukeig | | 2011 |
| Selfy Buoy Marine Charters Limited | Transport & logistics | 2025 |
| Seligo Ltd | Professional & scientific | 2008 |
| Selladoor (US Holdings) Limited | Arts & recreation | 2020 |
| Selladoor Creation Limited | Arts & recreation | 2015 |
| Selladoor Worldwide Limited | Arts & recreation | 2014 |
| Sellers Duffill Limited | Hospitality | 2024 |
| Sellers Leisure Limited | Hospitality | 2015 |
| Semtex Combat Sports Limited | Arts & recreation | 2013 |
| Sennock Electrical Services Ltd | Construction | 2024 |
| Sennocke Investments Ltd | Real estate | 2022 |
| Sennocke Residential Ltd | Real estate | 2016 |
| Sennocke Services Limited | Hospitality | 1986 |
| Seomama Limited | Information & communication | 2018 |
| Seraphina Socials Ltd | Information & communication | 2023 |
| Serena Mathur Limited | Professional & scientific | 2022 |
| Serene Strength Pilates Limited | Education | 2024 |
| Serenity Hair & Beauty Rooms Limited | Health & social care | 2019 |
| Servico Group Ltd | Administrative & support | 2025 |
| Sese Group Ltd | Construction | 2023 |
| SET Point Ltd | Information & communication | 2026 |
| Seven Dials Publishing Limited | Information & communication | 2012 |
| Sevenoaks & District Business Crime Reduction Partnership | Other services | 2003 |
| Sevenoaks & District Chamber of Commerce Limited | Administrative & support | 1994 |
| Sevenoaks Art Shop Ltd | Wholesale & retail | 2025 |
| Sevenoaks Automotive Limited | Wholesale & retail | 2019 |
| Sevenoaks Bikes Limited | Wholesale & retail | 2024 |
| Sevenoaks Bookshop Limited | Wholesale & retail | 2015 |
| Sevenoaks Borough Taxi Limited | Transport & logistics | 2025 |
| Sevenoaks Boxfit Ltd | Arts & recreation | 2019 |
| Sevenoaks Building Solutions Ltd | Construction | 2018 |
| Sevenoaks Business Centre Limited | Extraterritorial | 2005 |
| Sevenoaks Cardiology Ltd | Health & social care | 2026 |
| Sevenoaks Carpets Limited | Wholesale & retail | 1988 |
| Sevenoaks Catering Limited | Hospitality | 2019 |