| RPM Vehicle Sales Limited | Wholesale & retail | 2012 |
| RPS (Bristol) Consulting Ltd | Professional & scientific | 2021 |
| Ruffington Investments Ltd | Professional & scientific | 2019 |
| S & R Property Maintenance Limited | Construction | 2022 |
| S & W Gardner Catering Ltd. | Hospitality | 2002 |
| Sahara Talent Limited | Professional & scientific | 2007 |
| Salon 27 Limited | Other services | 2012 |
| Samaritan's Way Ltd | Wholesale & retail | 2022 |
| Sarah Cook Psychology Ltd | Health & social care | 2023 |
| Saxby & Sinden Limited | Professional & scientific | 2019 |
| School of Bodywork Ltd | Health & social care | 2023 |
| SCN Group Ltd | Financial services | 2017 |
| Sea Fresh Ltd | Hospitality | 2019 |
| Sea Kestrel Ltd | Agriculture & fishing | 2019 |
| Seahouse Trading Ltd | Extraterritorial | 2018 |
| Seasabre Ltd | Manufacturing | 2013 |
| Seaton and District Hospital League of Friends | Health & social care | 1990 |
| Seaton Beach Management Limited | Households | 2018 |
| Seaton Chamber CIC | Other services | 2023 |
| Seaton Chine Flats Limited | Households | 1984 |
| Seaton Community Arts CIC | Wholesale & retail | 2023 |
| Seaton Consultants Limited | Administrative & support | 2009 |
| Seaton Driving Companion Service Ltd | Health & social care | 2018 |
| Seaton Gateway Theatre Company Limited | Arts & recreation | 2016 |
| Seaton Hole Kiosk Limited | Hospitality | 2020 |
| Seaton Homes Ltd. | Construction | 2006 |
| Seaton Print & Design Ltd | Manufacturing | 2014 |
| Seaton Self Storage Ltd | Other services | 2013 |
| Seaton Tramway (Enterprises) Limited | Wholesale & retail | 2015 |
| Seatonpizza Ltd | Hospitality | 2018 |
| Seraph Psychology Ltd | Health & social care | 2020 |
| Serendipity Mind Body Soul Ltd | Wholesale & retail | 2023 |
| SGF Design & Build Ltd | Construction | 2014 |
| Sherwood Management Company (Lyme Regis) Limited | Real estate | 2005 |
| Ship Inn Axmouth Ltd | Hospitality | 2015 |
| Signature Build & Landscaping Ltd | Construction | 2026 |
| Simon Holmes Consultancy Ltd | Wholesale & retail | 2013 |
| Simply Unique Holidays Ltd | Hospitality | 2021 |
| SM Jones Plumbing & Heating Ltd | Construction | 2024 |
| Smart Analytical Ltd | Professional & scientific | 2016 |
| Smart Student Rentals Ltd | Real estate | 2018 |
| SMG (Sidmouth) Ltd | Hospitality | 2024 |
| SN Design & Build Ltd | Construction | 2018 |
| Sovereign Heights Residents Company Limited | Households | 2003 |
| Sports and Leisure (Seaton) Limited | Wholesale & retail | 2021 |
| Springhead Company Limited | Water & waste | 1980 |
| Springhead Data Limited | Information & communication | 2016 |
| Starboard House Ltd | Wholesale & retail | 2004 |
| Stockwell Financial Services Limited | Financial services | 2024 |
| Strawbridge Building Contractors Ltd | Construction | 2021 |
| Summit Property Group Southwest Ltd | Hospitality | 2022 |
| Suon International Limited | Professional & scientific | 1997 |
| Super RAW Design Ltd | Wholesale & retail | 2026 |
| Sustainable Project Live CIC | Education | 2024 |
| Sutton Coldfield Counselling Limited | Health & social care | 2021 |
| SWM Safety & Security Consultancy Limited | Administrative & support | 2014 |
| Synergistic Encounters Limited | Professional & scientific | 2010 |
| T J Mitchell Ltd | Financial services | 2020 |
| T&C Brands Ltd | Professional & scientific | 2018 |
| Tall Mast & Tower Maintenance Ltd | Construction | 2001 |
| Taste of Devon Butchers Limited | Wholesale & retail | 2020 |
| Taste of Thai Devon Limited | Hospitality | 2023 |
| Taylor Psychology Services Ltd | Health & social care | 2021 |
| Taylor-Wilkinson Limited | Real estate | 2018 |
| Technical Support Solutions Limited | Professional & scientific | 2009 |
| Thatchcraft Ltd | Construction | 2002 |
| Thatching Advisory Services (UK) Ltd. | Construction | 2009 |
| THE AXE Valley Heritage Association | Arts & recreation | 1987 |
| THE Binge Eating Therapist Ltd | Health & social care | 2020 |
| THE Canine Behaviour College Ltd | Education | 2024 |
| THE Colonnades (Hackney) Freehold Company Limited | Households | 2017 |
| THE Colonnades (Hackney) Management Company Limited | Households | 1985 |
| THE Dorset Hideaway Holidays Ltd | Hospitality | 2021 |
| THE Emdr Psychology Company Ltd | Health & social care | 2022 |
| THE Functional Mushroom Company Ltd | Manufacturing | 2021 |
| THE Great Brexhibition Limited | Professional & scientific | 2017 |
| THE GUY in the TIE Ltd | Other services | 2022 |
| THE Havens RTM Company Limited | Households | 2024 |
| THE Holden Practice Ltd | Health & social care | 2023 |
| THE Infinity Health Hub Ltd | Health & social care | 2023 |
| THE Italian Seltzer Company Limited | Manufacturing | 2020 |
| THE Linen House Seaton Ltd | Other services | 2026 |
| THE Little Care Group Ltd | Health & social care | 2026 |
| THE Multi-Family Project CIC | Health & social care | 2024 |
| THE Neurodiversity Practice Ltd | Health & social care | 2023 |
| THE Old Forge Fossil Co. Limited | Wholesale & retail | 1999 |
| THE Old School Press Ltd | Information & communication | 1998 |
| THE Outsider's Perspective Ltd | Professional & scientific | 2015 |
| THE Parkstone Practice Ltd | Health & social care | 2025 |
| THE Quartz Management Company Limited | Households | 1998 |
| THE Sea Shanty Branscombe LLP | | 2018 |
| THE Trauma Recovery Space Ltd | Health & social care | 2025 |
| THE Tree GUY Devon Ltd | Administrative & support | 2023 |
| Theodore Trist Ltd. | Construction | 2008 |
| Think CBT Limited | Health & social care | 2012 |
| Thomill Ltd | Professional & scientific | 2024 |
| Thornemoor Ltd | Professional & scientific | 2015 |
| Thornfield Close Resident Management Ltd | Households | 2023 |
| Thrive Healthcare Solutions Limited | Health & social care | 2022 |
| Tioata Solutions Ltd | Information & communication | 2026 |