| Printuitive Ltd | Manufacturing | 2025 |
| Pro-Motion Engineering Ltd | Manufacturing | 2016 |
| Proactive Paraplanning Ltd | Financial services | 2023 |
| Procom Consultancy Ltd | Professional & scientific | 2021 |
| Procom Training Limited | Transport & logistics | 2014 |
| Projects Ace Limited | Construction | 2018 |
| Property Protection Services (UK) Ltd | Other services | 2017 |
| Providus Health Limited | Administrative & support | 2010 |
| Pspd Limited | Extraterritorial | 2025 |
| Pure Sussex Distillery Ltd | Manufacturing | 2017 |
| Quality Management Projects Limited | Professional & scientific | 2012 |
| Quality Rents Ltd | Real estate | 2020 |
| R Aftab Ltd | Health & social care | 2023 |
| R H Properties Sussex Limited | Real estate | 2022 |
| Raise Podcast Ltd | Information & communication | 2025 |
| Rakco Limited | Real estate | 2017 |
| Rampion Cleaning Services Limited | Administrative & support | 2019 |
| Ranger Removals & Storage Ltd | Transport & logistics | 2024 |
| RAS Websites Limited | Information & communication | 2024 |
| Rasool & Sons Ltd | Transport & logistics | 2026 |
| Rastafairis Ltd | Manufacturing | 2025 |
| RBW Media Limited | Administrative & support | 2014 |
| Rdjh Locum Pharm Ltd | Wholesale & retail | 2025 |
| Ready to Trade Ltd | Professional & scientific | 2025 |
| Real White Wolf Media Ltd | Arts & recreation | 2014 |
| Reddot Games Studios Ltd | Information & communication | 2022 |
| Redemption Fitness Ltd | Arts & recreation | 2016 |
| Reel Consultancy Ltd | Professional & scientific | 2024 |
| Reel Holding ( South UK) Ltd | Wholesale & retail | 2025 |
| Reel Sales Ltd | Wholesale & retail | 2025 |
| Regent Construction Management Ltd | Financial services | 2023 |
| Resilient-Class Ltd | Professional & scientific | 2026 |
| Reviive Sports Limited | Manufacturing | 2024 |
| RG Management Services Limited | Professional & scientific | 2019 |
| Richard Barrow Agencies Limited | Wholesale & retail | 2007 |
| Richmond Court (Seaford) Maintenance Company Limited | Real estate | 1961 |
| Riedu Ltd | Hospitality | 2018 |
| Right Click Properties Limited | Real estate | 2019 |
| Rinsed Bathrooms Ltd | Construction | 2024 |
| Riverside Court (Newhaven) Limited | Households | 1984 |
| RJH Commercials Ltd | Wholesale & retail | 2025 |
| RLH Marketing Ltd | Professional & scientific | 2023 |
| Rlpm Limited | Professional & scientific | 2020 |
| Robust Machinery Limited | Manufacturing | 2015 |
| Roebuck House Hastings Limited | Households | 2025 |
| Romy Jones Education Ltd | Education | 2020 |
| Roomly PMS Ltd | Information & communication | 2025 |
| Rosary Court Maintenance Limited | Households | 1972 |
| Routine 2000 (UK) Limited | Real estate | 1999 |
| Rowland Gorringe (Seaford) Limited | Extraterritorial | 2017 |
| Roys Convenience Store Limited | Wholesale & retail | 2023 |
| Roza's Coffee Ltd | Hospitality | 2025 |
| RRG Medical Services Ltd | Health & social care | 2010 |
| RRG Property Ltd | Real estate | 2020 |
| Ruminant Audio Works Ltd | Arts & recreation | 2026 |
| Run Properties Ltd | Real estate | 2021 |
| Russel&Sukie Ltd | Construction | 2025 |
| Ruth Wharton Osteopath Limited | Health & social care | 2009 |
| Rutherford Electrical Services Limited | Construction | 2015 |
| S T B Motors Ltd | Wholesale & retail | 2012 |
| SA Properties (London) Ltd | Construction | 2022 |
| Sable Consultancy Ltd | Professional & scientific | 2025 |
| Sailhaven Community Interest Company | Transport & logistics | 2019 |
| Sailing Projects Ltd | Arts & recreation | 2013 |
| Sailsirimanikart Ltd | Real estate | 2024 |
| Salisbury Court Seaford Limited | Professional & scientific | 2005 |
| Salt and Pebble Designs Ltd | Wholesale & retail | 2023 |
| Salts Holiday Lets Ltd | Real estate | 2025 |
| Sanders Electrical Contractors Ltd | Construction | 2025 |
| SC Southern Ltd | Construction | 2023 |
| Scan-Uk Timber Limited | Other services | 1991 |
| Scaptrani Dental Limited | Health & social care | 2022 |
| Scentiment Floristry Ltd | Wholesale & retail | 2024 |
| Scts Limited | Professional & scientific | 2005 |
| SDP Alternatives Limited | Financial services | 2018 |
| Sea Smile Care Ltd | Health & social care | 2023 |
| Seachester Limited | Real estate | 1963 |
| Seachester One Limited | Professional & scientific | 2013 |
| Seaford Barbers Ltd | Other services | 2022 |
| Seaford Bonfire Society | Other services | 2019 |
| Seaford Builders Ltd | Construction | 2018 |
| Seaford Building Supplies Ltd | Wholesale & retail | 2024 |
| Seaford Care Limited | Health & social care | 2012 |
| Seaford Carers Ltd | Health & social care | 2013 |
| Seaford Court (Seaford) Limited | Real estate | 2000 |
| Seaford Electrical Limited | Construction | 2021 |
| Seaford Fish & Chips Limited | Hospitality | 2022 |
| Seaford Head Golf Club Limited | Arts & recreation | 1990 |
| Seaford Health Store Ltd. | Wholesale & retail | 2003 |
| Seaford Learning Trust | Education | 2012 |
| Seaford Nails Limited | Other services | 2025 |
| Seaford Podiatry & Chiropody Limited | Health & social care | 2019 |
| Seaford Precison Engineering Ltd | Construction | 2020 |
| Seaford Properties Sussex Ltd | Real estate | 2024 |
| Seaford Rugby Football Club | Arts & recreation | 2008 |
| Seaford Windscreens Limited | Wholesale & retail | 1980 |
| Seahaven Business Centre Ltd | Real estate | 2021 |
| Seahaven FM Broadcasting | Information & communication | 2008 |
| Seamore Views Limited | Real estate | 2007 |
| Sean Tucker Joinery Limited | Construction | 2008 |