| Scunthorpe Best Kebab Ltd | Hospitality | 2022 |
| Scunthorpe Bowl Limited | Arts & recreation | 2019 |
| Scunthorpe Car Wash Ltd | Administrative & support | 2019 |
| Scunthorpe Care Ltd | Health & social care | 2025 |
| Scunthorpe Commercial Mobile Fleet Care Ltd | Wholesale & retail | 2024 |
| Scunthorpe Computers Ltd | Wholesale & retail | 2014 |
| Scunthorpe Darts Shop Limited | Wholesale & retail | 2026 |
| Scunthorpe Eats Limited | Wholesale & retail | 2024 |
| Scunthorpe Hot Tubs Limited | Wholesale & retail | 2022 |
| Scunthorpe Instant Print Limited | Manufacturing | 1976 |
| Scunthorpe Landlords Association CIC | Real estate | 2025 |
| Scunthorpe Lawnmowers Limited | Wholesale & retail | 2008 |
| Scunthorpe Market Cafe Limited | Hospitality | 2020 |
| Scunthorpe Masonic Building Management Board (Properties) Limited | Other services | 1995 |
| Scunthorpe MOT Centre Garages Ltd | Wholesale & retail | 2018 |
| Scunthorpe Plumbing & Heating Commercial Limited | Other services | 2024 |
| Scunthorpe Raceway Limited | Arts & recreation | 2003 |
| Scunthorpe Scrap Cars Limited | Wholesale & retail | 2025 |
| Scunthorpe Seamless Gutters Ltd | Other services | 2019 |
| Scunthorpe Sheds and Fencing Ltd | Administrative & support | 2025 |
| Scunthorpe Sheet Metal (2010) Limited | Manufacturing | 2010 |
| Scunthorpe Tuition Limited Partnership | | 2016 |
| Scunthorpe United Football Club Limited | Arts & recreation | 1912 |
| SD Property Lettings Ltd | Real estate | 2019 |
| Sdac Limited | Construction | 2026 |
| Sdchafer Services Ltd | Professional & scientific | 2025 |
| Sdmfg Ltd | Construction | 2020 |
| Sdnb Limited | Health & social care | 2022 |
| Sean Moloney Limited | Construction | 2012 |
| Sebiks Limited | Transport & logistics | 2023 |
| Secondbyte IT Ltd | Wholesale & retail | 2025 |
| Secrets Beauty Spa Limited | Other services | 2010 |
| Seemyability Ltd | Real estate | 2024 |
| Selby Cottage Transport Limited | Transport & logistics | 2004 |
| Selena Courier Ltd | Transport & logistics | 2025 |
| Selim Ioan Trucking Ltd | Transport & logistics | 2026 |
| Selin (York) Limited | Hospitality | 2019 |
| Selysofy Ltd | Hospitality | 2025 |
| SEM Property Hub Ltd | Real estate | 2026 |
| Sending Graces Ltd | Wholesale & retail | 2026 |
| Senior Soluble Solutions Ltd | Manufacturing | 2025 |
| Sentex Hydraulix Ltd. | Manufacturing | 2015 |
| Sentinel Fire Risk Limited | Financial services | 2024 |
| Sentinel Structures Ltd | Construction | 2019 |
| Serban Pro Recruitment Ltd | Administrative & support | 2025 |
| Sethi Family Ltd | Construction | 2025 |
| Seven 11 Properties Ltd | Real estate | 2024 |
| Seven Two Investments Ltd | Real estate | 2020 |
| Sevo Living Ltd | Real estate | 2019 |
| Sevo Supermarket Ltd | Wholesale & retail | 2019 |
| SEW Medical Ltd | Professional & scientific | 2024 |
| SEW Perfectly Precious Limited | Manufacturing | 2020 |
| Seyyal Ltd. | Hospitality | 2019 |
| SFC Foods Limited | Hospitality | 2026 |
| SFC North Lincs Ltd | Hospitality | 2023 |
| Sftc Cars Ltd | Wholesale & retail | 2015 |
| SG Customs Limited | Wholesale & retail | 2022 |
| SGI 2019 Limited | Financial services | 2024 |
| Sgkc Electrical Ltd | Construction | 2021 |
| Shadow Art Games Ltd | Information & communication | 2022 |
| Shadow Bridge Limited | Manufacturing | 2023 |
| Shadow Crown Services Ltd | Wholesale & retail | 2017 |
| Shane Brocklehurst Transport Limited | Transport & logistics | 2018 |
| Shane Potter Properties Limited | Construction | 2016 |
| Shankara Holding Ltd | Real estate | 2025 |
| Shannon Group Holdings Limited | Financial services | 2025 |
| Sharazwr Motors Ltd | Wholesale & retail | 2024 |
| Sharpe Bloodstock Limited | Arts & recreation | 2023 |
| Sharrow Holdings Limited | Real estate | 2022 |
| Sharrow Vale Holdings Limited | Real estate | 2023 |
| Shaw Accountancy Services Ltd | Professional & scientific | 2016 |
| Shaw Plumbing and Heating Limited | Construction | 2015 |
| Shawarma Time Kebab Ltd | Hospitality | 2025 |
| Shayth Group Limited | Financial services | 2025 |
| Shehbaz Ltd | Transport & logistics | 2025 |
| Sheik Entities Limited | Construction | 2022 |
| Sheldon Leisure Ltd | Hospitality | 2012 |
| Sher Khan Properties Ltd | Real estate | 2025 |
| Sheriff Holdings Limited | Financial services | 2023 |
| Sheriff RBI Consultants Limited | Professional & scientific | 2019 |
| Shift Traffic Events Limited | Transport & logistics | 2014 |
| Shihabamazon Ltd | Wholesale & retail | 2024 |
| Shipcote Driving Solutions Ltd | Transport & logistics | 2025 |
| Shirab Ltd | Real estate | 2026 |
| Shire Surveys Limited | Professional & scientific | 2002 |
| Shiva Retail Ltd | Wholesale & retail | 2018 |
| Shop and EAT Limited | Wholesale & retail | 2026 |
| Short & Sons Properties Ltd | Real estate | 2025 |
| Showmans Limited | Hospitality | 2018 |
| Shucksmith Accountants (Gainsborough) Limited | Professional & scientific | 2006 |
| Shucksmith Accountants (Scunthorpe) Limited | Professional & scientific | 1994 |
| Shutterup Photography Ltd | Professional & scientific | 2024 |
| Siak Ltd | Arts & recreation | 2020 |
| Sidachle Limited | Information & communication | 2019 |
| Siemarks Limited | Professional & scientific | 2022 |
| Sign Detail Limited | Wholesale & retail | 2014 |
| Sigotrans Ltd | Transport & logistics | 2019 |
| Sikorski Security Ltd | Administrative & support | 2023 |
| Silakan Property Limited | Real estate | 2022 |
| Silver Birch Blinds Limited | Construction | 2020 |