| Ryton Beef Limited | Agriculture & fishing | 2009 |
| S & J Cladding Solutions Limited | Construction | 2017 |
| S & P Darwell Limited | Financial services | 1990 |
| S K Archive Limited | Manufacturing | 2026 |
| S L J Installations Limited | Construction | 2020 |
| S Mcmillan Machinery Solutions Ltd | Manufacturing | 2026 |
| S R J Developments (Yorkshire) Ltd | Construction | 1997 |
| S R S Developments (Scarborough) Ltd | Construction | 2013 |
| S West Property Investments Limited | Real estate | 2022 |
| S&J Holdings (Yorkshire) Limited | Financial services | 2020 |
| S&N Property Developments Limited | Construction | 2022 |
| S. Eblet Limited | Construction | 2003 |
| S.A.Inston and Company Limited | Wholesale & retail | 1963 |
| S.L.S. Yorkshire Limited | Administrative & support | 2007 |
| SAB & Barbers Ltd | Other services | 2024 |
| Sabaash Limited | Administrative & support | 2025 |
| Sabre Court Limited | Health & social care | 2014 |
| Sabroso Burrito and Nacho Bar Limited | Hospitality | 2019 |
| Sabroso Cakes Limited | Wholesale & retail | 2023 |
| Sabs CUT Ltd | Other services | 2025 |
| Saeweard Limited | Wholesale & retail | 2026 |
| Safha Ltd | Other services | 2021 |
| Safiya Tandoori Limited | Hospitality | 2024 |
| Sailor Jenkinson Limited | Construction | 2021 |
| Saint Catherines Hospice Lottery Limited | Arts & recreation | 1998 |
| Saint Catherines Hospice Trust | Health & social care | 1982 |
| Salma Amreen Limited | Health & social care | 2021 |
| Salman Sons Limited | Hospitality | 2021 |
| Salome Strategy Limited | Information & communication | 2021 |
| Saltkae by the Sea Limited | Real estate | 2026 |
| Saltkae Limited | Real estate | 2025 |
| Salty Geek Limited | Professional & scientific | 2024 |
| SAM Cartwright Joinery & Building Contractors Ltd | Extraterritorial | 2016 |
| SAM Noble Eyecare Limited | Wholesale & retail | 2021 |
| Sanan Suearak Limited | Hospitality | 2025 |
| Sandersons of Yorkshire Ltd | Transport & logistics | 2023 |
| Sandfield House Farm Ltd | Hospitality | 2017 |
| Sandra Calvert Lettings Limited | Real estate | 2012 |
| Sandside Apartments Limited | Hospitality | 2025 |
| Sandside Commercial Catering Ltd | Hospitality | 2026 |
| Sandside Ltd | Wholesale & retail | 2023 |
| Sandwell Court Limited | Households | 2018 |
| Sarah Bolton Ltd | Administrative & support | 2021 |
| Sarah Jane's Pets Ltd | Wholesale & retail | 2019 |
| Saughtree Station Limited | Hospitality | 2023 |
| Saunter Homes Ltd | Real estate | 2023 |
| SAVE9 Holdings Limited | Information & communication | 2011 |
| SAVE9 Limited | Information & communication | 2002 |
| Sawdon Country Cottages Management Company Limited | Real estate | 2010 |
| Saywell Subsea Services Limited | Construction | 2017 |
| SB Construction Compliance Limited | Professional & scientific | 2024 |
| SBA Electrical Limited | Construction | 2014 |
| SBD Yorkshire Ltd | Real estate | 2023 |
| SBE Investments Unlimited | Real estate | 2020 |
| SC Gibson Electrical Services Ltd | Construction | 2026 |
| Scalby Mill Inn Ltd | Hospitality | 2015 |
| Scalby Mills Court Management Company Limited | Households | 1988 |
| Scalby Taxis Ltd | Transport & logistics | 2023 |
| Scalby Tops Ltd | Hospitality | 2022 |
| Scarbados Lets Limited | Real estate | 2021 |
| Scarbattan Farms Limited | Agriculture & fishing | 1974 |
| Scarborough & District Motor Club Limited | Other services | 1947 |
| Scarborough and Locals Together Limited | Wholesale & retail | 2014 |
| Scarborough Angling Online Ltd | Wholesale & retail | 2025 |
| Scarborough Autopaint UK Ltd | Construction | 2023 |
| Scarborough Bar Services Ltd | Hospitality | 2018 |
| Scarborough BC Ltd | Transport & logistics | 2023 |
| Scarborough BED Warehouse Limited | Wholesale & retail | 2015 |
| Scarborough Boardriders Club Community Interest Company | Education | 2023 |
| Scarborough Business Ambassadors | Administrative & support | 2008 |
| Scarborough Carpet Centre Limited | Extraterritorial | 2011 |
| Scarborough Cars Ltd | Wholesale & retail | 2019 |
| Scarborough Classic Barber Ltd | Other services | 2023 |
| Scarborough College International Ltd | Education | 2026 |
| Scarborough College Limited | Education | 1896 |
| Scarborough Constitutional Club Company Limited(The) | Real estate | 1887 |
| Scarborough Counselling & Psychotherapy Training Institute Ltd | Education | 2013 |
| Scarborough Decking Limited | Extraterritorial | 2014 |
| Scarborough Decorators Ltd | Construction | 2011 |
| Scarborough Dental Care Limited | Health & social care | 2008 |
| Scarborough Denture Centre Ltd | Manufacturing | 2024 |
| Scarborough Digital Limited | Information & communication | 2017 |
| Scarborough Donuts Ltd | Hospitality | 2026 |
| Scarborough Fair Accommodation Two Ltd | Real estate | 2020 |
| Scarborough Film Festival CIC | Information & communication | 2023 |
| Scarborough Flooring Ltd | Wholesale & retail | 2006 |
| Scarborough Flower Fund Homes | Real estate | 1969 |
| Scarborough Gymnastics Academy Limited | Arts & recreation | 2014 |
| Scarborough Hand Car Wash Limited | Other services | 2017 |
| Scarborough Holiday Apartments Limited | Real estate | 2023 |
| Scarborough Hospice Sales Limited | Wholesale & retail | 1986 |
| Scarborough Hospitality Consultants Limited | Professional & scientific | 2026 |
| Scarborough Liberal Clubhouse Company Limited(The) | Real estate | 1893 |
| Scarborough Lifts Limited | Manufacturing | 1997 |
| Scarborough Lodge Owners Club Ltd | Hospitality | 2022 |
| Scarborough Marine Services Ltd | Agriculture & fishing | 2025 |
| Scarborough Maritime Heritage Centre Ltd | Education | 2008 |
| Scarborough Museums, Culture and Creative Trust | Arts & recreation | 2004 |
| Scarborough Museums, Culture and Creative Trust Enterprises Limited | Arts & recreation | 2006 |
| Scarborough North Cliff Golf Club Limited (the) | Arts & recreation | 1970 |