| Shed 10 Limited | Arts & recreation | 2013 |
| Shivaay Consultants Ltd | Administrative & support | 2017 |
| Shorebrook Limited | Construction | 2014 |
| Signwrite Studios Limited | Manufacturing | 2007 |
| Silver Bear Consulting Limited | Professional & scientific | 2012 |
| Silverstone Citi Ltd | Wholesale & retail | 2014 |
| Silverwood Removals Ltd | Transport & logistics | 2025 |
| Sima Freight Limited | Transport & logistics | 2025 |
| Simon Fenner Mortgage Solutions Limited | Financial services | 2014 |
| Simon Livingstone Ltd | Information & communication | 2022 |
| Simply Photography Limited | Professional & scientific | 2017 |
| SIR Paul Clarke Limited | Professional & scientific | 2013 |
| SIR Whippy Ltd | Wholesale & retail | 2019 |
| Sjholloway&Sons Limited | Wholesale & retail | 2017 |
| SJM Events Ltd | Hospitality | 2017 |
| Skaterboy Limited | Wholesale & retail | 2019 |
| Skbw Limited | Construction | 2025 |
| Skelmersdale Developments Limited | Real estate | 2021 |
| Skim Fresh Plastering Ltd | Construction | 2023 |
| Skippers Fish & Chips -Grilled Limited | Hospitality | 2025 |
| Skpi Limited | Administrative & support | 2015 |
| Skycite OHS Consultancy Ltd | Professional & scientific | 2024 |
| Sleek Marketing Ltd | Professional & scientific | 2022 |
| SLJ Services Limited | Other services | 2018 |
| SLV Electrical & Maintenance Services Limited | Manufacturing | 2002 |
| SM Pizza UK Limited | Hospitality | 2025 |
| Smarthouz Developments Limited | Construction | 2016 |
| SMD Construction Services Ltd | Construction | 2022 |
| Smilejin Ltd | Hospitality | 2026 |
| SNG (Southern) Ltd | Construction | 2014 |
| Snow Windows Ltd | Arts & recreation | 2015 |
| Snvp Private Limited | Wholesale & retail | 2025 |
| Soem Consulting Services Ltd | Other services | 2018 |
| Solutions ALL Ltd | Administrative & support | 2020 |
| Sonic Weld Ltd | Manufacturing | 2022 |
| Southern Print Finishing Services Limited | Manufacturing | 2005 |
| Spa Cleaning Solutions Ltd | Hospitality | 2013 |
| Spa Services London Limited | Administrative & support | 2014 |
| Splendour Healthcare Services Ltd | Health & social care | 2016 |
| Spot on Fitness Ltd | Arts & recreation | 2017 |
| SPS International (UK) Ltd | Administrative & support | 2008 |
| SR Accountants Ltd | Professional & scientific | 2011 |
| Stamel Ltd | Construction | 2012 |
| Starlight HR Ltd | Professional & scientific | 2024 |
| Starris Limited | Health & social care | 2020 |
| Stashable Ltd | Information & communication | 2025 |
| Step UP Foundation | Arts & recreation | 2013 |
| Stephanie Stevenson Ltd | Health & social care | 2002 |
| Stepup Sports Coaching Limited | Education | 2018 |
| Stepwise Success Ltd | Wholesale & retail | 2026 |
| Stewartsphere Ltd | Professional & scientific | 2025 |
| Stone Gould Property Group Limited | Real estate | 2017 |
| Stonecroft Capital Limited | Financial services | 2025 |
| Stonescape Design Co. Limited | Manufacturing | 2025 |
| Streamline Synergyy Limited | Administrative & support | 2024 |
| Stronghold Scaffolding Ltd | Construction | 2014 |
| Studio SEVENTY2 Ltd | Professional & scientific | 2025 |
| Suki & Sons Ltd | Real estate | 2024 |
| Sullessur Ltd | Real estate | 2023 |
| Summerflex Ltd | Construction | 2018 |
| Summitsoft Limited | Information & communication | 1999 |
| Sundrew Properties Partnership LLP | | 2021 |
| Supremax Limited | Hospitality | 2019 |
| Surtees Draincare Limited | Construction | 2019 |
| Surturflame Ltd | Construction | 2025 |
| Suzisocial Ltd | Professional & scientific | 2025 |
| Switch Smart Electrical Ltd | Manufacturing | 2023 |
| Symons Carpentry & Construction Ltd | Construction | 2017 |
| Synergy HR Limited | Administrative & support | 2025 |
| Syscon Justice Systems International Limited | Administrative & support | 2004 |
| System 7 Transport Services Limited | Transport & logistics | 2004 |
| System Solutions Logistics Limited | Information & communication | 1996 |
| T & S Cars Ltd | Transport & logistics | 2009 |
| T a Price Tree & Garden Services Ltd | Administrative & support | 2025 |
| T M Thornton Consultancy Ltd | Health & social care | 2018 |
| Tamedeveloper Ltd | Information & communication | 2024 |
| Tautoko Education Ltd | Information & communication | 2022 |
| Taxantics Limited | Professional & scientific | 2019 |
| TEACHER4ME Limited | Education | 2017 |
| Techspirit UK Ltd | Administrative & support | 2023 |
| Techtile Ltd | Construction | 2019 |
| Tekagac Invest Ltd | Real estate | 2025 |
| Terema Limited | Education | 2001 |
| TGA Gymnastics Ltd | Education | 2021 |
| Thames Valley Tubs Ltd | Other services | 2018 |
| THC Business Solutions Limited | Extraterritorial | 2019 |
| THC Consultants Ltd | Professional & scientific | 2024 |
| Thclub Limited | Information & communication | 2024 |
| THE AI Growth Club Ltd | Information & communication | 2026 |
| THE Brown Box Gift Company Ltd | Wholesale & retail | 2021 |
| THE Corvus Learning Trust | Education | 2017 |
| THE Dog Boss Ltd | Other services | 2022 |
| THE Flourishing Brain Limited | Information & communication | 2026 |
| THE GAS MAN Group Limited | Construction | 2020 |
| THE Gatekeeper Automation Ltd | Manufacturing | 2024 |
| THE Glove International Ltd | Information & communication | 2023 |
| THE Hive Life Ltd | Real estate | 2025 |
| THE Influential Partnership Limited | Professional & scientific | 2010 |
| THE Ricky Hatton Foundation | Other services | 2025 |
| THE Sound Studio UK Limited | Other services | 2005 |