| Clinixgroup Ltd | Professional & scientific | 2023 |
| CLR Autos Limited | Wholesale & retail | 2025 |
| CLR Group (Cheshire) Ltd | Transport & logistics | 2024 |
| Coach Cain Media Ltd | Education | 2023 |
| Coachcain Camp Limited | Arts & recreation | 2024 |
| CODE10 Ltd | Information & communication | 2025 |
| Cole Actuarial Limited | Financial services | 2022 |
| Cole Network Solutions Limited | Manufacturing | 2011 |
| Collective Therapies Ltd | Health & social care | 2014 |
| Comah Consulting Ltd | Professional & scientific | 2015 |
| Comet Environmental Ltd | Extraterritorial | 2014 |
| Comjal Consultancy Ltd | Professional & scientific | 2012 |
| Commercial Credit Limited | Professional & scientific | 1994 |
| Compass Complete Solutions Limited | Public administration | 2013 |
| Compass Digital Solutions Ltd | Public administration | 2013 |
| Compass Fire Solutions LLP | | 2010 |
| Coniston House Retail Ltd | Wholesale & retail | 2025 |
| Connectpay Ltd | Financial services | 2025 |
| Conrad James Independent Financial Advice Ltd | Financial services | 2012 |
| Conrad James Ltd | Financial services | 2020 |
| Consultancy and Management Solutions Ltd | Professional & scientific | 2016 |
| Cookson Engineering Ltd | Information & communication | 2024 |
| Cooper Live Limited | Administrative & support | 2016 |
| Copner Comms Ltd | Information & communication | 2017 |
| Copper Beeches Management Company Limited | Households | 2018 |
| Coppice Book-Keeping Limited | Professional & scientific | 2012 |
| Cottam Contractors Limited | Construction | 2018 |
| Cottam Contractors Northwest Limited Limited | Construction | 2024 |
| Cottam Contractors NW Ltd | Construction | 2026 |
| Country Roots Ltd | Hospitality | 2019 |
| Cova Security Gates Limited | Manufacturing | 1987 |
| CP Barbering Ltd | Other services | 2024 |
| CPB Properties & Lettings Ltd | Real estate | 2020 |
| CPE (Speciality Components) Limited | Manufacturing | 2000 |
| Cpmj Ltd | Real estate | 2014 |
| Crabtree Fisheries Ltd | Agriculture & fishing | 2025 |
| Crane & General Services Ltd | Administrative & support | 2011 |
| Crewe & Nantwich Timber Ltd | Manufacturing | 2018 |
| Crewe and Nantwich Accountants Ltd | Extraterritorial | 2022 |
| Crewe and Nantwich Windows Limited | Extraterritorial | 1993 |
| Crewe Barbershop Ltd | Other services | 2023 |
| Crewe Colour Printers Limited | Manufacturing | 1971 |
| Crewe Heritage Trust | Arts & recreation | 1992 |
| Crewe Property Ltd | Real estate | 2013 |
| Crewe Road Private Road Ltd | Real estate | 2022 |
| CRF Brightside Apartments Ltd | Real estate | 2023 |
| CRF Brightside Ltd | Financial services | 2023 |
| CRF Estates Ltd | Construction | 2020 |
| CRF the Meadows Ltd | Real estate | 2022 |
| Crig Developments Ltd | Construction | 2020 |
| Crlj Properties Limited | Real estate | 2026 |
| Crookie Limited | Administrative & support | 2025 |
| Crown Property Crewe Limited | Real estate | 2018 |
| Crownleaf Estates Limited | Real estate | 2000 |
| CS Casa Limited | Real estate | 2022 |
| CS Home Maintenance Ltd | Construction | 2026 |
| CS Vino Limited | Hospitality | 2017 |
| Cscat Limited | Professional & scientific | 2024 |
| CSM Window Cleaning Limited | Administrative & support | 2010 |
| Csms Ventures Ltd | Arts & recreation | 2025 |
| CT Group 1986 Ltd | Health & social care | 2023 |
| CT International Ltd | Financial services | 2016 |
| CT International Trade Finance UK Ltd. | Wholesale & retail | 2017 |
| CTA Supply Ltd | Administrative & support | 2018 |
| Cuddington Developments Limited | Construction | 2022 |
| Cupworks Ltd | Wholesale & retail | 2025 |
| Cutch Candles Ltd | Manufacturing | 2020 |
| Cutch Company Ltd | Wholesale & retail | 2020 |
| CW1 Butchers Limited | Wholesale & retail | 2022 |
| CW2 Leisure Ltd | Wholesale & retail | 2020 |
| CW2 Property Ltd | Real estate | 2022 |
| D & R Timber Supplies Ltd | Wholesale & retail | 2014 |
| D & S Helm Ltd | Financial services | 2023 |
| D Boydell Catering Ltd | Hospitality | 2025 |
| D&N Shotblasting & Painting Services Ltd. | Professional & scientific | 1993 |
| D.H.V. Roofing Ltd | Construction | 2024 |
| D11NXY Ltd | Other services | 2021 |
| D9 Signs & Wraps Ltd | Other services | 2021 |
| Dachshboard Limited | Other services | 2023 |
| Dacque Ltd | Manufacturing | 2025 |
| DAJ Construction Management Limited | Real estate | 2013 |
| Dakota Trading Limited | Wholesale & retail | 2018 |
| Dale and O'Connor Ltd | Education | 2026 |
| Dale Family Holdings 1 Limited | Financial services | 2025 |
| Dale Family Holdings 2 Limited | Financial services | 2025 |
| Dale Family Holdings 3 Limited | Financial services | 2025 |
| Daniel Matthias Architecture Limited | Professional & scientific | 2014 |
| Dapperapp Limited | Administrative & support | 2016 |
| Darlow Farriers Limited | Agriculture & fishing | 2008 |
| Darren Mulheir & Co Limited | Professional & scientific | 2018 |
| Darwen Windows Ltd | Wholesale & retail | 2019 |
| Data Exchange Ltd | Administrative & support | 2011 |
| Davenport Stables Holdings Limited | Financial services | 2019 |
| Davenport Stables Limited | Agriculture & fishing | 2012 |
| Davenports School & Leisure Outfitters Limited | Wholesale & retail | 2002 |
| David Alton Consultant Ltd | Professional & scientific | 2022 |
| David Fradley Building Contractors Limited | Construction | 2011 |
| DC Safety Services Ltd | Professional & scientific | 2012 |
| De-Stack Clothing Ltd | Wholesale & retail | 2026 |
| Deal Group Ltd | Wholesale & retail | 2026 |