| Prostrat Ltd | Administrative & support | 2024 |
| PSC Design Ltd | Professional & scientific | 2022 |
| Psych-Logical Ltd | Education | 2017 |
| Pure Intentions UK Online Ltd | Wholesale & retail | 2020 |
| Purple Recycle Ltd | Water & waste | 2019 |
| Qa-Ra Huntcliff UK Ltd | Health & social care | 2017 |
| Quirky Bars Ltd | Hospitality | 2023 |
| Quirky Crew Ltd | Administrative & support | 2025 |
| R & I Kirkbright Limited | Construction | 2004 |
| R Abel & SON Ltd | Hospitality | 2022 |
| Raising Aspirations Empowering Change Limited | Professional & scientific | 2016 |
| Raspison Joinery Contractors Limited | Construction | 2016 |
| RBR Lodges Ltd | Hospitality | 2025 |
| Re-Ewes Limited | Hospitality | 2015 |
| Real Meals Limited | Wholesale & retail | 2001 |
| Rebecca Armstrong Design Ltd | Professional & scientific | 2019 |
| Recruit Digital Limited | Administrative & support | 2024 |
| Redbook I.T. Limited | Information & communication | 2010 |
| Redcar Education & Development Limited | Health & social care | 2007 |
| Rees Woodall Property Renovations Limited | Construction | 2015 |
| Reevive UK Ltd | Wholesale & retail | 2019 |
| Renntech Ltd | Wholesale & retail | 2025 |
| Retriever Technical Services Ltd | Professional & scientific | 2025 |
| Retro Revivals Servicing Ltd | Wholesale & retail | 2024 |
| Rgtradinguk Limited | Wholesale & retail | 2020 |
| Richardsons Site Services Ltd | Construction | 2024 |
| Ridgeline Roofing NE Ltd | Construction | 2026 |
| Riffs Hooks and Lines Ltd | Arts & recreation | 2024 |
| Riggmech Limited | Professional & scientific | 2024 |
| Rjbp Holdings Limited | Financial services | 2023 |
| Rjjp Services Limited | Administrative & support | 2021 |
| RM Cleansing Solutions Ltd | Manufacturing | 2020 |
| Roaming RAM Pizza Co Ltd | Wholesale & retail | 2025 |
| ROK Developments Ltd | Real estate | 2024 |
| Rose and Potter Delicatessen Limited | Hospitality | 2017 |
| RS Earthworks Limited | Construction | 2017 |
| RSB Construction (NE) Limited | Construction | 2012 |
| Rusty Magnet Limited | Hospitality | 2021 |
| S & J Bell Corporation Ltd | Real estate | 2024 |
| S & J Bell Holdings Ltd | Real estate | 2022 |
| S & J Bell Lettings Ltd | Hospitality | 2021 |
| S & J Bell Limited | Real estate | 2018 |
| S Caukwell Auto Body Repairs Ltd | Wholesale & retail | 2019 |
| S&Q Ltd | Hospitality | 2024 |
| S.D Collitt Engineering Ltd | Professional & scientific | 2023 |
| Saaa Property Ltd | Real estate | 2023 |
| Safecut.Co.Uk Ltd | Manufacturing | 2024 |
| Saltburn Artists Projects | Arts & recreation | 1998 |
| Saltburn Christian Projects | Health & social care | 1998 |
| Saltburn Coral Limited | Hospitality | 2022 |
| Saltburn Estates Limited | Real estate | 2017 |
| Saltburn Folk Festival | Arts & recreation | 2019 |
| Saltburn Food Ltd | Hospitality | 2022 |
| Saltburn Friends of the Valley Ltd | Education | 2013 |
| Saltburn Golf Club Services Limited | Hospitality | 2019 |
| Saltburn Motorhome Hire Limited | Administrative & support | 2024 |
| Saltburn Official Ltd | Wholesale & retail | 2025 |
| Saltburn School of Music Ltd | Education | 2025 |
| Saltburn-By-The-Sea Golf Club Ltd | Arts & recreation | 1967 |
| Sami Horam Limited | Other services | 2023 |
| Samson Industrial Rope Access Ltd | Construction | 2016 |
| Sandringham Consultancy Services Limited | Wholesale & retail | 2015 |
| Sandy Toes Property Management Limited | Real estate | 2025 |
| Sara Perry Consulting Ltd | Administrative & support | 2023 |
| Sbts Consulting Ltd | Professional & scientific | 2025 |
| Scaling DAM Sailing and Watersports Club | Arts & recreation | 2021 |
| Scaling Firewood Company Ltd | Agriculture & fishing | 2018 |
| SCM Security Ltd | Administrative & support | 2023 |
| Scorpio Rizing Limited | Wholesale & retail | 2024 |
| Scoundrels Coffee Co Ltd | Hospitality | 2023 |
| Scurator Limited | Professional & scientific | 2005 |
| Sdde Smith Family Holdings Limited | Financial services | 2023 |
| SDP Offshore Wind Ltd | Manufacturing | 2025 |
| Seadrift Cafe Limited | Hospitality | 2011 |
| Seamer Electrical Ltd | Construction | 2025 |
| Seaside Inns Ltd | Hospitality | 2021 |
| SECTION20 Limited | Real estate | 2004 |
| Sector 33 Limited | Real estate | 2020 |
| Seekers Search Ltd | Administrative & support | 2020 |
| Sellhealth Ltd | Wholesale & retail | 2024 |
| Senses Wellbeing Centre C.I.C. | Health & social care | 2019 |
| Serenity Properties (NE) Limited | Real estate | 2018 |
| Serpent King Games Ltd | Information & communication | 2010 |
| Shorty's Gins Ltd | Wholesale & retail | 2018 |
| Shutters”R”Us Ltd | Wholesale & retail | 2021 |
| Sicliano Pizzeria Ltd | Hospitality | 2025 |
| Signals Saltburn Limited | Hospitality | 2013 |
| Silver Lining Nutrition Ltd | Manufacturing | 2012 |
| Simon Wrigley Total Building Solutions Ltd | Construction | 2020 |
| Simple Perfect Limited | Arts & recreation | 2016 |
| SJW Renovations NE Ltd | Construction | 2025 |
| Skelton & Gilling Estates Properties Limited | Real estate | 2013 |
| Skelton Auto Services Ltd | Wholesale & retail | 2026 |
| Skelton Estates Limited | Real estate | 2013 |
| Skelton Farming Limited | Agriculture & fishing | 2005 |
| Skelton Fast Food Ltd | Hospitality | 2025 |
| Skelton Function Fitness Ltd | Arts & recreation | 2019 |
| Skelton Super Store Limited | Wholesale & retail | 2024 |
| Skelton Take Away Ltd | Hospitality | 2024 |
| Skinology Aesthetics Limited | Other services | 2019 |