| E R M Electrical Ltd | Construction | 2018 |
| E-Inspire Limited | Information & communication | 2010 |
| Earthbeat Ltd | Health & social care | 2004 |
| East Cleveland Cars Limited | Wholesale & retail | 2015 |
| East Cleveland Housing Limited | Real estate | 2019 |
| East Cleveland Youth Housing Trust | Construction | 2000 |
| Easy Shipment (Ezship) Ltd | Water & waste | 2021 |
| EC Davies Holdings UK Limited | Financial services | 2020 |
| Ecoflow Consultants Ltd | Information & communication | 2025 |
| Edward House (Owners) Limited | Households | 1996 |
| Eighty Eight DEV Ltd | Information & communication | 2021 |
| Electricity Limited | Arts & recreation | 2022 |
| Elevate Your Decor Ltd | Wholesale & retail | 2026 |
| Elise Electrical Services Ltd | Construction | 2024 |
| Ellerby Hotel Ltd | Hospitality | 2022 |
| Emma Charles Ltd. | Manufacturing | 2016 |
| Emmanuel Fishing Ltd | Agriculture & fishing | 2018 |
| Enersurv Limited | Professional & scientific | 2020 |
| EOS Development Limited | Transport & logistics | 2025 |
| Erimus Projects Ltd | Professional & scientific | 2025 |
| Evenden Electrical Ltd | Construction | 2015 |
| Everett Mcnamara Ltd | Administrative & support | 2026 |
| Evermore Collective Limited | Information & communication | 2025 |
| Exopest Limited | Agriculture & fishing | 2016 |
| F&R Coffee Limited | Hospitality | 2026 |
| Fairmont Engineering Limited | Manufacturing | 2025 |
| Farm Direct Countrystore Limited | Wholesale & retail | 2018 |
| FB Builders Ltd | Construction | 2024 |
| Fearnhead Residential Limited | Health & social care | 1998 |
| Fifteen South Ltd | Professional & scientific | 2024 |
| Fircroft Electrical Services Limited | Construction | 2015 |
| Fitwide Limited | Real estate | 1986 |
| FKW Fitness Limited | Arts & recreation | 2026 |
| Flexi Training (North East) Ltd | Administrative & support | 2010 |
| FM Investments (NE) Limited | Real estate | 2017 |
| Foleys Equestrian Ltd | Wholesale & retail | 2025 |
| Foodsphere Qualifications Limited | Education | 2020 |
| Forget Hotels Laundry Lounge Ltd | Other services | 2024 |
| Forty SIX and 2 Ltd | Construction | 2021 |
| Foster Welding Services Ltd | Wholesale & retail | 2025 |
| France Drilling Consultants Ltd | Construction | 2023 |
| Friendly Food City Ltd | Wholesale & retail | 2019 |
| Frimbet Limited | Real estate | 2025 |
| Froom Barbers Ltd | Other services | 2022 |
| Fuel'D by Coffee Ltd | Hospitality | 2026 |
| G Robinson Engineering Limited | Professional & scientific | 2014 |
| G. Welburn Lighting Limited | Professional & scientific | 2023 |
| Gannon Developments Limited | Construction | 2017 |
| Gatesbridge Ltd | Professional & scientific | 2013 |
| GAZ Monkey Mobile Ltd | Wholesale & retail | 2025 |
| Genevara Limited | Hospitality | 1987 |
| Gettagrip Ltd | Manufacturing | 2022 |
| Ghalayini Property Group Limited | Real estate | 2018 |
| GO2 Data Management Solutions Limited | Information & communication | 2018 |
| GO2 Property Management Ltd | Hospitality | 2020 |
| Going for Independence Community Interest Company | Administrative & support | 2008 |
| Gorilla Imports NE Ltd | Wholesale & retail | 2024 |
| Graeme Hinchliffe Consultancy Ltd | Professional & scientific | 2018 |
| Graftrule Limited | Wholesale & retail | 1985 |
| Grange Court Owners Group Ltd | Real estate | 2021 |
| Green Lane Capital (157 Albert Road) LLP | | 2012 |
| Green Lane Capital (Albert RD) LLP | | 2012 |
| Green Lane Capital (Boldon) LLP | | 2014 |
| Green Lane Capital (Gibson House Middlesbrough) LLP | | 2010 |
| Green Lane Capital (Hebburn) LLP | | 2012 |
| Green Lane Capital (Mandale) LLP | | 2013 |
| Green Lane Capital (N/E) LLP | | 2006 |
| Green Lane Capital Limited | Real estate | 2012 |
| Greta Cottage Holdings Limited | Financial services | 2019 |
| Greylands Groundworks and Construction Limited | Construction | 2010 |
| Grovekey Limited | Agriculture & fishing | 1994 |
| GT Flood Consulting Limited | Professional & scientific | 2024 |
| Guest Homes Ltd | Real estate | 2018 |
| Guisborough Brewery Ltd | Manufacturing | 2019 |
| GY and Son's Trading Limited | Financial services | 2020 |
| H T S Services Limited | Construction | 2018 |
| H&S Voyage Holdings Limited | Financial services | 2024 |
| H2 Carbon Clean Ltd | Wholesale & retail | 2026 |
| Hair by Emily Ltd | Other services | 2023 |
| Hair Expressions of Skelton Ltd | Other services | 2005 |
| Harker Developments Limited | Real estate | 2025 |
| Harper Process Engineering Ltd | Professional & scientific | 2020 |
| Harry Traders Ltd | Wholesale & retail | 2024 |
| Healing Hands Ltd | Health & social care | 2003 |
| Hendersons Flooring Ltd | Wholesale & retail | 2024 |
| Heritage Stoves Ltd | Wholesale & retail | 2024 |
| Hewitson Engineering Limited | Professional & scientific | 2011 |
| HG Web Solutions Ltd | Professional & scientific | 2026 |
| High Winds Cottages Limited | Hospitality | 2015 |
| Highfield (North East) Limited | Education | 2009 |
| HIP Bars Ltd | Hospitality | 2026 |
| HKG Business Services Limited | Information & communication | 2015 |
| Hlwarren Ltd | Health & social care | 2024 |
| HOB Retail Limited | Wholesale & retail | 2026 |
| Holmes Catherine Ltd | Construction | 2018 |
| Home by Anna Ltd | Wholesale & retail | 2024 |
| Home-Visit Eyecare Ltd | Health & social care | 2008 |
| Honeywell Construction Services Limited | Construction | 2007 |
| Horse Trader Pro Limited | Professional & scientific | 2019 |
| Host & Stay FM Group Limited | Financial services | 2023 |