| Medwise Staffing Solutions Ltd | Administrative & support | 2024 |
| MEW Training Limited | Real estate | 2020 |
| Millennium Court (Greenside) RTM Company Limited | Households | 2013 |
| Moody & Co Maintenance Limited | Construction | 2020 |
| Motor Genie Limited | Wholesale & retail | 2025 |
| Movd Ltd | Information & communication | 2026 |
| NAV Hospitality Ltd | Professional & scientific | 2021 |
| Nenn Limited | Hospitality | 2022 |
| New Guard Mental Health Training Delivery CIC | Wholesale & retail | 2021 |
| NO.6 Online Training Limited | Arts & recreation | 2025 |
| Nolarys System Ltd | Construction | 2019 |
| Norland Hobbies Ltd | Manufacturing | 2021 |
| North East Music Foundation C.I.C. | Education | 2011 |
| North East Recovery Coaching Limited | Health & social care | 2025 |
| North Place Property Ltd | Real estate | 2025 |
| Northeastvaletmasters Ltd | Administrative & support | 2026 |
| Northern Angels Consultancy Limited | Professional & scientific | 2012 |
| Northern Education Trust | Education | 2010 |
| Northumberland Roofing Limited | Other services | 2014 |
| Northumbria Business Services Limited | Administrative & support | 2004 |
| Nourish-Ed Healthcare Ltd | Health & social care | 2024 |
| Novocastrian One Limited | Households | 2014 |
| NTW Handyman Services Ltd | Other services | 2025 |
| OLI & Joes (Ryton) Ltd | Hospitality | 2017 |
| Optimal Security Systems Ltd | Administrative & support | 2022 |
| Orbitor Innovation Ltd | Professional & scientific | 2026 |
| Ormotec Ltd | Information & communication | 2019 |
| Ormston Fabrication Ltd | Manufacturing | 2009 |
| Page 3 Competitions Ltd | Wholesale & retail | 2025 |
| Pandas Online Ltd | Professional & scientific | 2022 |
| Parafango Limited | Construction | 2014 |
| Pathway Lighting UK Limited | Professional & scientific | 2008 |
| PAW Proof Ltd | Other services | 2013 |
| PB Traffic Management Ltd | Construction | 2025 |
| Pilatease Ryton Ltd | Health & social care | 2023 |
| Pink Property Homes Ltd | Real estate | 2026 |
| Ponteland Taxis Limited | Transport & logistics | 2020 |
| Positive About Inclusion CIC | Professional & scientific | 2020 |
| Prevail Digital Ltd | Information & communication | 2014 |
| Prizm Technical Services Ltd | Manufacturing | 2017 |
| Procut Grounds Maintenance Ltd | Administrative & support | 2021 |
| Project Mayhem Ltd | Other services | 2011 |
| Protein Culture Ltd | Hospitality | 2020 |
| Pull UP the Roots Ltd | Hospitality | 2021 |
| QUICK2DISCOVER Limited | Information & communication | 2000 |
| R-Tech Engineering Ltd | Professional & scientific | 2024 |
| Rampart Commercial Properties Ltd | Real estate | 2026 |
| Rampart Installations Limited | Manufacturing | 2013 |
| RAR Investments Portfolio Limited | Real estate | 2024 |
| Rebelle Marketing Ltd | Professional & scientific | 2024 |
| Red Kite PUB Co Ltd | Hospitality | 2026 |
| Redcherryit Limited | Professional & scientific | 2013 |
| Renovo Solutions Limited | Manufacturing | 2018 |
| Renovo T C UK Limited | Manufacturing | 2022 |
| Renovo Tool Co Limited | Manufacturing | 2022 |
| RHD Construction & Environmental Contractors Ltd | Construction | 2013 |
| Robin Building Services Ltd | Construction | 2014 |
| Rockwood Ltd | Construction | 2018 |
| Rodneys Chop Shop Limited | Other services | 2018 |
| Romo Property Ltd | Real estate | 2023 |
| Rosedale Property Investments Limited | Real estate | 2024 |
| Ross Forbes Communications Limited | Professional & scientific | 2014 |
| Ryton Accountancy Ltd | Professional & scientific | 2002 |
| Ryton Barber Ltd | Other services | 2025 |
| Ryton Breakers Salvage Limited | Wholesale & retail | 2008 |
| Ryton Construction Limited | Construction | 2017 |
| Ryton Garage Ltd | Wholesale & retail | 2023 |
| Ryton Garden Takeaway Ltd | Hospitality | 2026 |
| Ryton Golf Club Limited | Arts & recreation | 2002 |
| Ryton Group Limited | Professional & scientific | 2025 |
| Ryton Lodges Management Ltd | Other services | 2012 |
| Ryton Roofers Limited | Construction | 2024 |
| S & G Digital Limited | Wholesale & retail | 2025 |
| S and J Chippy Ltd | Hospitality | 2023 |
| S Davidson Holdings Limited | Financial services | 2020 |
| SAM Quigley Aeronautical Limited | Professional & scientific | 2021 |
| Sayffur Ltd | Wholesale & retail | 2024 |
| SCQ Workshops Limited | Arts & recreation | 2016 |
| Sealed Tight Solutions Limited | Manufacturing | 2014 |
| Selborne Business Services Ltd | Professional & scientific | 2005 |
| Semibreve CIC | Arts & recreation | 2023 |
| Shape Performance Ltd | Arts & recreation | 2006 |
| Shepherdson Therapy Ltd | Health & social care | 2024 |
| Shining Stars Occupational Therapy Ltd | Health & social care | 2024 |
| Show UP Club Ltd | Wholesale & retail | 2020 |
| Sidhu Golden FRY Ltd | Hospitality | 2023 |
| Skim King Plastering Limited | Construction | 2016 |
| Smiths Front of House Limited | Hospitality | 2016 |
| Snap City Ltd | Wholesale & retail | 2020 |
| Solace by Scarlett Rose Ltd | Other services | 2026 |
| Spadenext Limited | Real estate | 2002 |
| Sparky Development Ltd | Information & communication | 2018 |
| Sparta Goalkeeping Limited | Wholesale & retail | 2015 |
| Specialist Building Solutions Limited | Professional & scientific | 2002 |
| ST. Agnes Day Nursery | Education | 2008 |
| Stanley Group of Companies Ltd | Administrative & support | 2020 |
| Stanley Wines Newcastle Ltd | Wholesale & retail | 2025 |
| Stargate Accident Management Limited | Wholesale & retail | 2026 |
| Stargate Property Company Limited | Real estate | 1998 |
| Steri-X Technology Ltd | Professional & scientific | 2013 |