| Classic Image Limited | Construction | 2009 |
| Classic Projects Ltd | Construction | 2021 |
| Claxton Consulting Limited | Professional & scientific | 2014 |
| Clear View Training Limited | Information & communication | 2000 |
| Click Solent Limited | Wholesale & retail | 2017 |
| Clive Thorogood Building Surveying Limited | Professional & scientific | 2019 |
| Cliveden Close Management Company Limited | Real estate | 1998 |
| Cloud 9 Hair Salon Limited | Other services | 2020 |
| Clyde House Residents (Ryde) Management Company Limited | Households | 2005 |
| CMT Repair Services Ltd | Other services | 2024 |
| Coast Holiday Homes Limited | Real estate | 2021 |
| Coast Homes Limited | Construction | 2015 |
| Code of Freedom Ltd | Administrative & support | 2025 |
| Commercial and Industrial Services Isle of Wight Limited | Construction | 2010 |
| Community Murals IOW CIC | Construction | 2024 |
| Complete Solutions IOW Ltd | Professional & scientific | 2021 |
| Connolly Blade & Wind Services Ltd | Construction | 2026 |
| Conrad Lettings Limited | Real estate | 2022 |
| Cool-Heat Services (IOW) Limited | Other services | 2004 |
| Copperpot Holdings Limited | Information & communication | 2024 |
| Copsefield Properties Limited | Construction | 1986 |
| Corevape Ltd | Wholesale & retail | 2025 |
| Cornerstone Accommodation Ltd | Real estate | 2019 |
| Cosán Cróga Ltd | Administrative & support | 2019 |
| Court & Spark Associates Ltd | Administrative & support | 2011 |
| Courtney's Care Ltd | Other services | 2024 |
| Cove Shop Ltd | Wholesale & retail | 2014 |
| Cowes Launderette Limited | Other services | 2023 |
| Cowes Water Taxis Limited | Transport & logistics | 1994 |
| CP Hire Agency Ltd | Administrative & support | 2026 |
| Craft Catering IW Ltd | Hospitality | 2025 |
| Craft IW Ltd | Hospitality | 2025 |
| Creative Rocket Ltd | Professional & scientific | 2023 |
| Crepe Lovers Ltd | Hospitality | 2020 |
| Critchlows Garage Ltd | Wholesale & retail | 2025 |
| Crusaders' Union, Limited(The) | Other services | 1925 |
| CS Spaces Ltd | Real estate | 2020 |
| Cycleisland Community Interest Company | Health & social care | 2018 |
| Cygnus ERI Ltd | Professional & scientific | 2024 |
| D & S (Ryde) Holdings Limited | Extraterritorial | 2013 |
| D & S 10A George Street Investments Ltd | Hospitality | 2025 |
| D & S 10B George Street Investments Ltd | Hospitality | 2025 |
| D & S 10C Investments Ltd | Hospitality | 2025 |
| D & S 13A Investments Ltd | Hospitality | 2025 |
| D & S Castle Street Investments Ltd | Hospitality | 2025 |
| D & S Church Lane Investments Ltd | Hospitality | 2025 |
| D & S Development ( Cowes ) Ltd | Real estate | 2023 |
| D & S Investments ( Cowes ) Ltd | Real estate | 2023 |
| D & S West Street Investments Ltd | Hospitality | 2025 |
| D by 3 Limited | Administrative & support | 2012 |
| D H Marine Services Ltd | Construction | 2017 |
| D.W. Jarvis Family Butchers Limited | Wholesale & retail | 2014 |
| Dairy Capital Limited | Information & communication | 2020 |
| Darryl Snow Photography Ltd | Professional & scientific | 2023 |
| Davey IOW Ltd | Construction | 2021 |
| David Aaron Bishop Limited | Manufacturing | 2024 |
| DB Vectis Ltd | Construction | 2023 |
| Delf House Management Company Limited | Professional & scientific | 1998 |
| Deli-Cious Artisan Bakery Co Ltd | Manufacturing | 2022 |
| Delta Sierra Ltd | Information & communication | 2018 |
| DEN DEN Company Limited | Hospitality | 2023 |
| Denops Ltd | Information & communication | 2022 |
| Design FAB Ltd. | Professional & scientific | 2015 |
| Desktop Print Studio Ltd | Manufacturing | 2019 |
| Devson Investments Ltd | Real estate | 2017 |
| Devson Property Services Ltd | Real estate | 2014 |
| Diabo Ltd | Health & social care | 2012 |
| Diamond Wight Properties Ltd | Real estate | 2023 |
| Digital Eaze Limited | Professional & scientific | 2016 |
| Digital Yurt Limited | Information & communication | 2018 |
| Dineley Ltd | Wholesale & retail | 2014 |
| Dlwjr Events Ltd | Administrative & support | 2025 |
| Dockd Ltd | Administrative & support | 2024 |
| Dodsworth Property Ltd | Real estate | 2025 |
| Double OR Nothing Limited | Information & communication | 2019 |
| Dover House Management Company Limited | Households | 1987 |
| Downing Carpentry Ltd | Construction | 2012 |
| Drastic Reimagining Ltd | Information & communication | 2024 |
| DSM Cloud Technologies UK Ltd | Information & communication | 2020 |
| DTF Services Ltd | Administrative & support | 2025 |
| Dunstone Simpkin Ltd | Construction | 2025 |
| Dynamic Vision Opticians Ltd | Wholesale & retail | 2025 |
| Eaglehigh Composites Limited | Professional & scientific | 2018 |
| East Medina Lodge NO. 175 Ltd | Other services | 2023 |
| East Woodside Ltd | Households | 2010 |
| Eastridge Management Limited | Households | 2021 |
| Echo Financial Planning LLP | | 2014 |
| Ecoreflect Ltd | Professional & scientific | 2013 |
| Eddington Field Limited | Households | 2014 |
| Edward Hospitality Ltd | Hospitality | 2025 |
| Edwards Catering Ltd | Hospitality | 2025 |
| Eeles Blade Specialist Ltd | Manufacturing | 2025 |
| Egan Ventures Limited | Wholesale & retail | 2007 |
| Egremont (Ryde) (Maintenance) Limited | Real estate | 1974 |
| Electric Island Ltd | Administrative & support | 2020 |
| Electrical Building Solutions Ltd | Construction | 2011 |
| Electricall IOW Ltd | Construction | 2011 |
| Elfmade Ltd | Wholesale & retail | 2013 |
| Elite Property Maintenance and Services Limited | Administrative & support | 2022 |
| Elizabeth Harris Medical Cosmetics Ltd | Health & social care | 2022 |