| Develop People Ltd. | Professional & scientific | 2009 |
| Devevo Ltd | Information & communication | 2016 |
| DG Hall Photography Ltd | Professional & scientific | 2024 |
| Diagnostics.Uk Ltd | Wholesale & retail | 2025 |
| Dialled in Consultants Limited | Professional & scientific | 2021 |
| Dianthus Land Ltd | Professional & scientific | 2016 |
| Diarchy Ltd | Other services | 2023 |
| Digital DEN Holdings Ltd | Wholesale & retail | 2019 |
| Digital Direction (Consultants) Limited | Information & communication | 2010 |
| Digital Heraldry Ltd | Professional & scientific | 2024 |
| Digital Mysteries Ltd. | Arts & recreation | 1997 |
| Digitalbytembi Ltd | Professional & scientific | 2025 |
| Digswell Park Limited | Other services | 1952 |
| Display Graphics Limited | Manufacturing | 2017 |
| Dissipate Limited | Information & communication | 2008 |
| Divall Design Limited | Professional & scientific | 2016 |
| Divergent Theatre Ltd | Education | 2019 |
| DJT Building Services Ltd | Construction | 2026 |
| Dlits Limited | Information & communication | 2025 |
| DNA Recruit Limited | Extraterritorial | 2016 |
| Dodnash Estates Limited | Extraterritorial | 1990 |
| Dog & Bone Limited | Administrative & support | 2010 |
| Dogtooth Technologies Limited | Professional & scientific | 2014 |
| Dolphin Homes Cambridge Ltd | Real estate | 2024 |
| Dolphin Place Management Company Limited | Households | 2007 |
| Dolphin Yard Limited | Real estate | 2010 |
| Dorah Limited | Health & social care | 2014 |
| Doris Mdzinwa Limited | Health & social care | 2013 |
| Dougle and Blanket Ltd | Financial services | 2020 |
| Dovmann Ltd | Information & communication | 2022 |
| Down to Earth Retreats Ltd | Extraterritorial | 2016 |
| Downsway Court Management Limited | Real estate | 1987 |
| DPH Group Ltd | Administrative & support | 2016 |
| Draft Construction Ltd | Information & communication | 2025 |
| Dramatic Grooves Ltd | Wholesale & retail | 2021 |
| Dramatic Growth Ltd | Arts & recreation | 2016 |
| Dribble Ltd | Information & communication | 2023 |
| Drumcliff Films Limited | Information & communication | 2019 |
| Drury & Gard Brickwork Ltd | Construction | 2011 |
| DSL Licencing Limited | Wholesale & retail | 2007 |
| Dual Clutch Tech Ltd | Wholesale & retail | 2026 |
| Dual Fire Protection Limited | Professional & scientific | 2008 |
| Dubhouse Investments Limited | Real estate | 2023 |
| Ducks FLY Together Ltd | Wholesale & retail | 2022 |
| Duggin Consulting Limited | Professional & scientific | 2017 |
| Duncan Developments Ltd | Construction | 2025 |
| Duncan Electrical Limited | Manufacturing | 2022 |
| Dunthorne Development Consulting Limited | Real estate | 2017 |
| DVS Resources Limited | Hospitality | 2012 |
| Dynamic Ducks Ltd | Administrative & support | 2016 |
| Dynamic New Alliances Ltd | Administrative & support | 2007 |
| Dynamic Pharma Consulting Ltd | Professional & scientific | 2025 |
| Dynamic Places Limited | Real estate | 2023 |
| E & G Energy Limited | Other services | 2015 |
| E Tyre Solutions Ltd | Wholesale & retail | 2024 |
| E-Pho Ltd | Professional & scientific | 2025 |
| E. Venture Systems Limited | Information & communication | 1998 |
| E.W.Pepper Limited | Agriculture & fishing | 1949 |
| Eagle Controls International Limited | Manufacturing | 1974 |
| Eagle Motion Limited | Professional & scientific | 2017 |
| Earl House Management Limited | Households | 2015 |
| Early Connections CIC | Health & social care | 2019 |
| East END Farm Limited | Professional & scientific | 2020 |
| Eastgrove Properties Limited | Real estate | 1999 |
| Eaton Hamry Consultants Limited | Construction | 2017 |
| Eatsport Limited | Other services | 2019 |
| Ecatlakss Ltd | Transport & logistics | 2025 |
| ECB Translation Ltd | Professional & scientific | 2023 |
| Eccentrix Ltd | Wholesale & retail | 2018 |
| Eclipse Building Limited | Households | 2004 |
| Eco Business Solutions Limited | Wholesale & retail | 2023 |
| Eco Solutions (C&R) Limited | Manufacturing | 1990 |
| Ecosyl Products Limited | Extraterritorial | 1996 |
| Ecton Finance Limited | Financial services | 2020 |
| Edge Design and Sourcing Ltd | Wholesale & retail | 2020 |
| Edge Electrical Ltd | Construction | 2023 |
| Edge Logistic Services Limited | Transport & logistics | 2022 |
| Edginton Stanley Wealth Management Ltd | Other services | 2019 |
| EDI Auto Garage Ltd | Wholesale & retail | 2024 |
| Edinburgh Instruments Limited | Manufacturing | 1969 |
| Edinburgh Sensors Limited | Manufacturing | 1984 |
| Edwards Services Ltd | Transport & logistics | 2024 |
| Ehee Ltd | Professional & scientific | 2020 |
| EHS Developments Ltd | Construction | 2025 |
| Eidolon Studios Ltd | Information & communication | 2011 |
| EIS Technology Consultancy Limited | Professional & scientific | 2013 |
| EJ Reynolds Consulting Ltd | Professional & scientific | 2022 |
| Elawam for Import and Export Ltd | Wholesale & retail | 2020 |
| Element 404 Ltd | Professional & scientific | 2025 |
| ELG Electrical Ltd | Construction | 2018 |
| Elite 4 Collectables Limited | Wholesale & retail | 2022 |
| Elixir Garden Supplies Ltd | Wholesale & retail | 2012 |
| ELM Court (Peymans) Ltd | Hospitality | 2017 |
| Elma Enterprises Limited | Professional & scientific | 2010 |
| Elmaw Consulting Limited | Professional & scientific | 2007 |
| Eloise Limited | Hospitality | 2004 |
| ELS Creations Ltd | Wholesale & retail | 2026 |
| Eltek Limited | Manufacturing | 1985 |
| Emerald Property Partners Limited | Construction | 2023 |
| Emile DE Londres Limited | Other services | 2019 |