| Emotion Pixels Limited | Information & communication | 2007 |
| Emotionally Available School Ltd | Education | 2026 |
| Empato Limited | Wholesale & retail | 2021 |
| Empearla and Mandan Projects Ltd | Real estate | 2023 |
| Empearla Group Limited | Real estate | 2023 |
| Empearla Prop Trading Ltd | Information & communication | 2026 |
| Empire Facade Group Ltd | Manufacturing | 2021 |
| Empire Floors Ltd | Wholesale & retail | 2025 |
| Empire Parties Limited | Arts & recreation | 2020 |
| Empire Properties (Leicester) Limited | Real estate | 2023 |
| Empire Properties and Developers Ltd | Real estate | 2022 |
| Empire Tech Enterprises Limited | Wholesale & retail | 2025 |
| EMPIRE14 Ltd | Wholesale & retail | 2022 |
| Emporio Events Ltd | Hospitality | 2025 |
| Empower Your Roots CIC | Administrative & support | 2024 |
| Empress & Hawk Ltd | Real estate | 2024 |
| Emray Services Ltd | Wholesale & retail | 2025 |
| Emre 68 Ltd | Hospitality | 2024 |
| Emre Express Limited | Hospitality | 2019 |
| Emre Hazal Ltd | Wholesale & retail | 2017 |
| Emrejan Food Ltd | Wholesale & retail | 2025 |
| EMS & K Limited | Construction | 2019 |
| EMS Property Developers Ltd | Real estate | 2022 |
| EMS Trade Ltd | Construction | 2014 |
| Emsmedical Ltd | Water & waste | 2025 |
| Emsons Corporation Ltd | Health & social care | 2014 |
| Emstate Ltd | Real estate | 2022 |
| Emtec Machine Tools Limited | Wholesale & retail | 2019 |
| Emtec Properties Limited | Administrative & support | 2012 |
| EMV Contractors Limited | Construction | 2022 |
| EMY Construction Ltd | Construction | 2015 |
| ENA Plus Services Limited | Administrative & support | 2023 |
| Enable Training Solutions Limited | Professional & scientific | 2014 |
| Enamir Properties Ltd | Real estate | 2026 |
| Encap Systems Limited | Information & communication | 2022 |
| Encargo Ltd | Administrative & support | 2025 |
| Encompass Medics Limited | Health & social care | 2023 |
| Encore Trading Limited | Wholesale & retail | 2022 |
| END Goal Elite Fitness Ltd | Health & social care | 2025 |
| Endeavour FST Ltd. | Education | 2014 |
| Endosphere & Beauty Balance Ltd | Other services | 2025 |
| Enea Papa Limited | Information & communication | 2019 |
| Energy Food Ltd | Manufacturing | 2019 |
| Energy Healer Sunita Ltd | Health & social care | 2021 |
| Enerlux Energy Ltd | Construction | 2025 |
| Engine 4 YOU Ltd | Wholesale & retail | 2020 |
| Engine Build Ltd | Wholesale & retail | 2020 |
| Engine FIX Centre Ltd | Wholesale & retail | 2026 |
| Engine Inside Ltd | Manufacturing | 2026 |
| Engine Professionals U.K Limited | Wholesale & retail | 2024 |
| Engine Rebuilding Equipment Company Ltd | Wholesale & retail | 2019 |
| Engine Repair and Services Ltd | Wholesale & retail | 2024 |
| Engineering Delivery Management Ltd | Professional & scientific | 2021 |
| Engineering LE Ltd | Other services | 2014 |
| Engineers & Solutions Ltd | Information & communication | 2014 |
| Engrave OUT Limited | Wholesale & retail | 2025 |
| ENI Enterprises Limited | Hospitality | 2019 |
| Enigma Luxurious Limited | Wholesale & retail | 2025 |
| Enigma Telecommunications Limited | Information & communication | 2024 |
| Enike Group Ltd | Administrative & support | 2017 |
| Enikul Ltd | Wholesale & retail | 2024 |
| ENJ Finance Limited | Professional & scientific | 2015 |
| Enjay Claims Limited | Financial services | 2012 |
| Enjay Limited | Financial services | 2008 |
| Enjoy Fashion Limited | Wholesale & retail | 2025 |
| ENL Construction Limited | Construction | 2024 |
| Enlight Investment Group Limited | Financial services | 2024 |
| Enodel UK Ltd | Professional & scientific | 2019 |
| Enrych Living Ltd | Arts & recreation | 2025 |
| Ensight Property Ltd | Construction | 2019 |
| Ensure Homes Limited | Real estate | 2019 |
| Enterlight Limited | Wholesale & retail | 2025 |
| Enterprise House Properties Limited | Real estate | 2015 |
| Enterprise Store Limited | Other services | 2020 |
| Entertainarts Limited | Arts & recreation | 2009 |
| Entity Dynamic Systems Ltd. | Information & communication | 2017 |
| Entreel Ltd | Information & communication | 2026 |
| Enviroflame Limited | Construction | 2025 |
| Environmental Health Consultancy (GB) Ltd | Professional & scientific | 2008 |
| Envirovent Essex Ltd | Construction | 2022 |
| Envotech Ltd | Wholesale & retail | 2024 |
| Envoy VFX Limited | Information & communication | 2022 |
| Enzy Solutions Ltd | Manufacturing | 2022 |
| Eolfire Ltd | Construction | 2026 |
| EPC Radiators Limited | Manufacturing | 2004 |
| Epcentral Ltd | Professional & scientific | 2024 |
| EPD Construction Services Ltd | Construction | 2022 |
| Epha Ltd | Professional & scientific | 2026 |
| Epic Shield Limited | Administrative & support | 2020 |
| Epic Sports Management Ltd | Arts & recreation | 2022 |
| Epicstandard Care Limited | Health & social care | 2013 |
| Epignosis EPN Limited | Wholesale & retail | 2016 |
| Epssc Services Limited | Real estate | 1995 |
| Epuff Ltd | Wholesale & retail | 2021 |
| Epyc Global Limited | Wholesale & retail | 2024 |
| EQ Events UK Limited | Information & communication | 2023 |
| Equal Edge CIC | Education | 2026 |
| Equine Mindful CIC | Education | 2026 |
| Equinox Real Estate Limited | Real estate | 2024 |
| Equitable Support Services Limited | Financial services | 2010 |