| Rumdoodle GAS Services Limited | Construction | 2013 |
| Runic Ltd | Information & communication | 2024 |
| Runway Luxe Ltd | Wholesale & retail | 2025 |
| Rural & County Builders Ltd | Construction | 2014 |
| Rushton Independent Funerals Ltd | Other services | 2023 |
| Rutland Water Cruises Ltd. | Transport & logistics | 1985 |
| S & JW Construction Limited | Construction | 2013 |
| S & O Conversions Limited | Construction | 2016 |
| S a Agricultural Services Limited | Agriculture & fishing | 2025 |
| S Donaldson Plumbing and Heating Ltd | Construction | 2022 |
| S P Conversions Limited | Construction | 2018 |
| S P Metcalfe Ltd | Agriculture & fishing | 2012 |
| S R M Joinery & Construction Limited | Construction | 2009 |
| Safe Harbour Films Ltd | Information & communication | 2020 |
| Safecard Alert Ltd | Information & communication | 2026 |
| Salix Provisions Limited | Wholesale & retail | 1995 |
| SALLY4TH Ltd | Manufacturing | 2017 |
| Salmist Ultraviolet Limited | Construction | 2021 |
| Salon Twenty Three Limited | Other services | 2025 |
| Salted Bomb Ltd | Information & communication | 2020 |
| Samuel Harrison Racing Ltd | Arts & recreation | 2025 |
| Sandhill Veterinary Services Limited | Professional & scientific | 2022 |
| Sandwood Consultants Limited | Professional & scientific | 2007 |
| Sarah Riley Ltd | Health & social care | 2024 |
| Sarah Tuer Limited | Real estate | 2022 |
| Sardo Construction Management Services Ltd | Construction | 2012 |
| Save the Dog Productions Limited | Information & communication | 2004 |
| Savi Partnership Limited | Health & social care | 2025 |
| Saxby’S Limited | Administrative & support | 2026 |
| Saynor and Sons Ltd | Real estate | 2020 |
| SC Maintenance and Building Ltd | Construction | 2026 |
| Scale Technologies Ltd | Manufacturing | 2023 |
| School Kitchen Limited | Hospitality | 2017 |
| Scott Paul Investments Limited | Real estate | 2008 |
| Scotton Park Projects Limited | Construction | 2021 |
| SCP Medical Holdings (UK) Limited | Financial services | 2018 |
| Sea Domestic Appliance Repair Service Limited | Manufacturing | 2011 |
| Sea View (Yorkshire) Limited | Hospitality | 2026 |
| Seesaw Property Services Limited | Real estate | 2020 |
| Selby Stone and Brickwork Ltd | Construction | 2024 |
| Semper Contracting Ltd | Construction | 2021 |
| Serius 1980 Limited | Hospitality | 2021 |
| SET the Tone Fitness Ltd | Arts & recreation | 2022 |
| Seven + Sixpence Limited | Professional & scientific | 2019 |
| Seven Meadows Ltd | Wholesale & retail | 2012 |
| Sevenmeadows UK Ltd | Professional & scientific | 2023 |
| SEW Centre Ltd | Wholesale & retail | 2022 |
| Sharow Asset Management Limited | Professional & scientific | 2012 |
| Sharow Community PUB Group Limited | Arts & recreation | 2023 |
| Sharow Medical Limited | Health & social care | 2014 |
| Sharp Holdings Winchester Limited | Professional & scientific | 2010 |
| Shaw Electrical Contractors Limited | Construction | 2015 |
| Sherringtons Sales and Lettings Limited | Real estate | 2017 |
| Sherwood Fencing Ltd | Construction | 2020 |
| Shinn Property Rentals Co Limited | Real estate | 2025 |
| Shoemaker House Limited | Real estate | 2014 |
| Shorten Management Consulting Limited | Professional & scientific | 2008 |
| SI Building Services Limited | Construction | 2018 |
| Siba | Other services | 1996 |
| Siba Commercial Services Ltd | Administrative & support | 2005 |
| Siennasol Limited | Wholesale & retail | 2010 |
| Signature Contract Hire & Leasing Limited | Extraterritorial | 2014 |
| Signature Motors Limited | Extraterritorial | 2007 |
| Silver Edge Services Limited | Construction | 2002 |
| Simon Rimmer Limited | Other services | 2009 |
| Simpson Retail Advisory Ltd | Professional & scientific | 2025 |
| SIR Henry Lawson-Tancred, Sons & Company Limited | Extraterritorial | 1976 |
| SK Orthopaedics Limited | Professional & scientific | 2018 |
| Skellbank Developments Ltd | Real estate | 2020 |
| Skellbank Mews Management Co. Limited | Households | 1984 |
| Skellfield Properties Limited | Real estate | 2019 |
| Skellfield Three Ltd | Information & communication | 2012 |
| Skellgate House Management Co Ltd | Households | 2020 |
| Skellgate Partners Limited | Households | 2010 |
| Skim Kingdom Ltd | Construction | 2026 |
| Sleningford Assets Ltd | Mining & quarrying | 2025 |
| Sleningford Water Mill Company Limited | Hospitality | 1973 |
| Sligo Holdings Ltd | Real estate | 2023 |
| Smithson's Court (Management) Limited | Professional & scientific | 2007 |
| Smithsons House Limited | Hospitality | 2015 |
| Snigwig Limited | Wholesale & retail | 2007 |
| Solemates Footwear (Ripon) Ltd | Wholesale & retail | 2018 |
| Solo Property Management Limited | Households | 2014 |
| Some Consulting Limited | Professional & scientific | 2022 |
| Something Cooking (Doncaster) Ltd | Hospitality | 2017 |
| Sommer Drinks Limited | Manufacturing | 2023 |
| Sonicflux Ltd | Administrative & support | 2025 |
| Soul Sista Yoga Ltd | Arts & recreation | 2024 |
| Source Mine Ltd | Real estate | 2021 |
| South Lodge Ripon Ltd | Hospitality | 2018 |
| South Stainley Developments Ltd | Real estate | 2015 |
| Southgate Property (Investments) Limited | Real estate | 2023 |
| Southgate Property Limited | Professional & scientific | 2015 |
| Southlawn Ltd | Administrative & support | 2012 |
| Spa Flats (Ripon) Limited | Households | 1973 |
| Spa Garage Luckspeed Group Ltd | Wholesale & retail | 2016 |
| Spa Vending Limited | Extraterritorial | 2021 |
| Spacegreen Property Management Limited | Households | 1991 |
| Spatial Design Studio Ltd | Construction | 2012 |
| SPC Education UK Ltd | Education | 2022 |